Cited by 2,743interferon and immune responsesCytokine Signaling Pathways and InteractionsImmune Response and Inflammation

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Antiviral Actions of Interferons

Open access

Samuel, Charles E.·2001·Clinical Microbiology Reviews

DOI 10.1128/cmr.14.4.778-809.2001PMC PMC89003

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Abstract

SUMMARY: Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs. Furthermore, advances made while elucidating the IFN system have contributed significantly to our understanding in multiple areas of virology and molecular cell biology, ranging from pathways of signal transduction to the biochemical mechanisms of transcriptional and translational control to the molecular basis of viral pathogenesis. IFNs are approved therapeutics and have moved from the basic research laboratory to the clinic. Among the IFN-induced proteins important in the antiviral actions of IFNs are the RNA-dependent protein kinase (PKR), the 2′,5′-oligoadenylate synthetase (OAS) and RNase L, and the Mx protein GTPases. Double-stranded RNA plays a central role in modulating protein phosphorylation and RNA degradation catalyzed by the IFN-inducible PKR kinase and the 2′-5′-oligoadenylate-dependent RNase L, respectively, and also in RNA editing by the IFN-inducible RNA-specific adenosine deaminase (ADAR1). IFN also induces a form of inducible nitric oxide synthase (iNOS2) and the major histocompatibility complex class I and II proteins, all of which play important roles in immune response to infections. Several additional genes whose expression profiles are altered in response to IFN treatment and virus infection have been identified by microarray analyses. The availability of cDNA and genomic clones for many of the components of the IFN system, including IFN-α, IFN-β, and IFN-γ, their receptors, Jak and Stat and IRF signal transduction components, and proteins such as PKR, 2′,5′-OAS, Mx, and ADAR, whose expression is regulated by IFNs, has permitted the generation of mutant proteins, cells that overexpress different forms of the proteins, and animals in which their expression has been disrupted by targeted gene disruption. The use of these IFN system reagents, both in cell culture and in whole animals, continues to provide important contributions to our understanding of the virus-host interaction and cellular antiviral response.

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Items 401–474 of 474

Role of interferon-γ in immunity to herpes simplex virus
Yu, Z., Manickan, E., & Rouse, B. T. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.60.4.528 · Cited by 56
Measures and countermeasures in the modulation of initiation factor activities by viruses.
Sonenberg, N. (1990) · PubMed · Cited by 56
Adenovirus VAI RNA Antagonizes the RNA-Editing Activity of the ADAR Adenosine Deaminase
Lei, M., Liu, Y., & Samuel, C. E. (1998) · Virology · doi:10.1006/viro.1998.9162 · Cited by 55
Self-citation
The Interferon-Inducible, Double-Stranded RNA-Specific Adenosine Deaminase Gene (DSRAD) Maps to Human Chromosome 1q21.1–21.2
Weier, H. G., George, C. X., Greulich, K. M., et al. (1995) · Genomics · doi:10.1006/geno.1995.0034 · Cited by 55
Reoviruses and the Interferon System
Samuel, C. E. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-72095-6_7 · Cited by 54
Self-citation
Generation of G-to-A and C-to-U Changes in HIV-1 Transcripts by RNA Editing
Bourara, K., Litvak, S., & Araya, A. (2000) · Science · doi:10.1126/science.289.5484.1564 · Cited by 53
Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin
Patel, R. C., Stanton, P., & Sen, G. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32351-7 · Cited by 51
Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes
Sherry, B., Baty, C. J., & Blum, M. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6709-6715.1996 · Cited by 51
Modification of retroviral RNA by double-stranded RNA adenosine deaminase
Hajjar, A. M., & Linial, M. L. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5878-5882.1995 · Cited by 51
PKR: Proposed Nomenclature for the RNA-Dependent Protein Kinase Induced by Interferon
Clemens, M. J., Hershey, J. W. B., Hovanessian, A. G., Jacobs, B. C., Katze, M. G., Kaufman, R. J., Lengyel, P., Samuel, C. E., Sen, G. C., & Williams, B. R. G. (1993) · Journal of Interferon Research · doi:10.1089/jir.1993.13.241 · Cited by 51
Self-citation
Surprising specificity of PKR binding to delta agent genomic RNA.
CIRCLE, D. A., Neel, O. D., Robertson, H. D., et al. (1997) · PubMed · Cited by 48
Role of the Vaccinia Virus E3L and K3L Gene Products in Rescue of VSV and EMCV from the Effects of IFN-α
Shors, S. T., Beattie, E., Paoletti, E., et al. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.721 · Cited by 48
Mechanism of interferon action: inhibition of vesicular stomatitis virus replication in human amnion U cells by cloned human leukocyte interferon. II. Effect on viral macromolecular synthesis.
Masters, P. S., & Samuel, C. E. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44335-3 · Cited by 47
Self-citation
Cell Growth Regulatory and Antiviral Effects of the P69 Isozyme of 2−5 (A) Synthetase
Ghosh, A., Sarkar, S. N., & Sen, G. C. (2000) · Virology · doi:10.1006/viro.1999.0085 · Cited by 47
Nomenclature of the Human Interferon Genes a
Dı́az, M. O., Bohlander, S. K., & Allen, G. F. G. (1994) · Journal of Interferon Research · doi:10.1089/jir.1994.14.221 · Cited by 47
Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling
Prejean, C., & Colamonici, O. R. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0311 · Cited by 47
Inhibition of Replication of Reactivated Human Immunodeficiency Virus Type 1 (HIV-1) in Latently Infected U1 Cells Transduced with an HIV-1 Long Terminal Repeat-Driven PKR cDNA Construct
Muto, N. F., Martinand‐Mari, C., Adelson, M. E., & Suhadolnik, R. J. (1999) · Journal of Virology · doi:10.1128/jvi.73.11.9021-9028.1999 · Cited by 46
Structural Organization of the Human Gene (PKR) Encoding an Interferon-Inducible RNA-Dependent Protein Kinase (PKR) and Differences from Its Mouse Homolog
Kuhen, K., Shen, X., Carlisle, E., et al. (1996) · Genomics · doi:10.1006/geno.1996.0446 · Cited by 46
Sequence Variability of Borna Disease Virus: Resistance to Superinfection May Contribute to High Genome Stability in Persistently Infected Cells
Formella, S., Jehle, C., Sauder, C. J., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.7878-7883.2000 · Cited by 45
Effects of the route of infection on immunoglobulin G subclasses and specificity of the reovirus-specific humoral immune response
Major, A. S., & Cuff, C. F. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.5968-5974.1996 · Cited by 45
[Inhibition of vaccinia infection by a liquid factor in tissues infected by homologous virus].
Nagano, Y., & KOJIMA, Y. (1958) · PubMed · Cited by 45
Intercellular adhesions as determinants of tissue assembly and malignant invasion
Steinberg, M. S., & Foty, R. A. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199711)173:2 · Cited by 43
The 2-5A System: A Personal View
Kerr, I. M. (1987) · Journal of Interferon Research · doi:10.1089/jir.1987.7.505 · Cited by 42
Mechanism of Interferon Action: Functional Characterization of Positive and Negative Regulatory Domains That Modulate Transcriptional Activation of the Human RNA-Dependent Protein KinasePkrPromoter
Kuhen, K., & Samuel, C. E. (1999) · Virology · doi:10.1006/viro.1998.9536 · Cited by 41
Self-citation
Mechanism of interferon action: RNA-binding activity of full-length and R-domain forms ofthe RNA-dependent protein kinase PKR — Determination of K values for VAI and TAR RNAs
McCormack, S. J., & Samuel, C. E. (1995) · Virology · doi:10.1016/s0042-6822(95)80067-0 · Cited by 41
Self-citation
Gamma Interferon Impedes the Establishment of Herpes Simplex Virus Type 1 Latent Infection but Has No Impact on Its Maintenance or Reactivation in Mice
Lekstrom-Himes, J. A., LeBlanc, R. A., Pesnicak, L., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.14.6680-6683.2000 · Cited by 41
Mechanism of Interferon Action: Identification of Essential Positions within the Novel 15-Base-Pair KCS Element Required for Transcriptional Activation of the RNA-Dependent Protein Kinase pkr Gene
Kuhen, K., Vessey, J. W., & Samuel, C. E. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9934-9939.1998 · Cited by 40
Self-citation
Production, Purification, and Characterization of Recombinant 2′,5′-Oligoadenylate Synthetases
Sarkar, S. N., & Sen, G. C. (1998) · Methods · doi:10.1006/meth.1998.0627 · Cited by 39
Nomenclature of the Human Interferon Genes a
Dı́az, M. O., Bohlander, S. K., & Allen, G. F. G. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.179 · Cited by 39
Inhibition of Hepatitis B Virus Replication during Schistosoma mansoni Infection in Transgenic Mice
McClary, H., Koch, R. J., Chisari, F. V., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.289 · Cited by 38
Seroprevalence of antibodies to hepatitis E virus in the normal blood donor population and two aboriginal communities in Malaysia
Seow, H. F., Mahomed, N. M. B., Mak, J.-W., Riddell, M. A., Li, F., & Anderson, D. A. (1999) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(199910)59:2 · Cited by 37
Isoforms p69 and p100 of 2′,5′-Oligoadenylate Synthetase Induced Differentially by Interferons In Vivo and In Vitro
Witt, P. L., Marié, I. J., Robert, N., et al. (1993) · Journal of Interferon Research · doi:10.1089/jir.1993.13.17 · Cited by 37
Characterization of the Gene Encoding the 100-kDa Form of Human 2′,5′Oligoadenylate Synthetase
Rebouillat, D., Hovnanian, A., David, G., et al. (2000) · Genomics · doi:10.1006/geno.2000.6382 · Cited by 36
Chromosomal Assignment of the Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase (PRKR) to Human Chromosome 2p21-p22 and Mouse Chromosome 17 E2
Barber, G. N., Edelhoff, S., Katze, M. G., & Distèche, C. M. (1993) · Genomics · doi:10.1006/geno.1993.1262 · Cited by 36
The expression of both domains of the 69/71 kDa 2′,5′ oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti‐viral response
Marié, I. J., Rebouillat, D., & Hovanessian, A. G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00361.x · Cited by 36
Characterization of the Heparin-Mediated Activation of PKR, the Interferon-Inducible RNA-Dependent Protein Kinase
George, C. X., Thomis, D. C., McCormack, S. J., Svahn, C. M., & Samuel, C. E. (1996) · Virology · doi:10.1006/viro.1996.0364 · Cited by 35
Self-citation
Two Molecular Weight Forms of Human 2′,5′-Oligoadenylate Synthetase Have Different Activation Requirements
Ilson, D. H., Torrence, P. F., & Vilček, J. (1986) · Journal of Interferon Research · doi:10.1089/jir.1986.6.5 · Cited by 34
Experimental rotavirus diarrhoea in colostrum-deprived newborn calves: assay of treatment by administration of bacterially produced human interferon (Hu-IFN alpha 2).
Schwers, A., Broecke, C. V., Maenhoudt, M., et al. (1985) · PubMed · Cited by 33
p48 (ISGF-3γ) Is Involved in Interferon-α-induced Suppression of Hepatitis B Virus Enhancer-1 Activity
Nakao, K., Nakata, K., Yamashita, M., Tamada, Y., Hamasaki, K., Ishikawa, H., Kato, Y., Eguchi, K., & Ishii, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28075 · Cited by 33
D3: A Gene Induced During Myeloid Cell Differentiation of Linlo c-Kit+ Sca-1+ Progenitor Cells
Weiler, S. R., Gooya, J. M., Ortiz, M., et al. (1999) · Blood · doi:10.1182/blood.v93.2.527 · Cited by 33
Pathogenesis of Reovirus Infection
Sharpe, A. H., & Fields, B. N. (1983) · Springer eBooks · doi:10.1007/978-1-4899-0580-2_6 · Cited by 33
2‘,5‘-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits.
Salehzada, T., Silhol, M., Steff, A., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53018-0 · Cited by 32
Identification of the ATP Binding Domain of Recombinant Human 40-kDa 2′,5′-Oligoadenylate Synthetase by Photoaffinity Labeling with 8-Azido-[α-32P]ATP
Kon, N., & Suhadolnik, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19983 · Cited by 32
Biosynthesis of reovirus-specified polypeptides multiplication rate but not yield of reovirus serotypes 1 and 3 correlates with the level of virus-mediated inhibition of cellular protein synthesis
Munemitsu, S. M., & Samuel, C. E. (1984) · Virology · doi:10.1016/0042-6822(84)90254-x · Cited by 32
Self-citation
Double-Stranded RNA-Specific Adenosine Deaminase: Nucleic Acid Binding Properties
Liu, Y., Herbert, A. G., Rich, A., & Samuel, C. E. (1998) · Methods · doi:10.1006/meth.1998.0624 · Cited by 31
Self-citation
Adenosine-to-Inosine Conversion in mRNA
Rueter, S. M., & Emeson, R. B. (2014) · ASM Press eBooks · doi:10.1128/9781555818296.ch19 · Cited by 30
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Squire, J. A., Zhou, A., Hassel, B. A., et al. (1994) · Genomics · doi:10.1006/geno.1994.1033 · Cited by 30
Production and characterization of recombinant IgA
Chintalacharuvu, K. R., & Morrison, S. L. (1999) · Immunotechnology · doi:10.1016/s1380-2933(98)00012-8 · Cited by 30
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Hovnanian, A., Rebouillat, D., Levy, E. R., Mattéi, M., & Hovanessian, A. G. (1999) · Genomics · doi:10.1006/geno.1998.5737 · Cited by 28
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Wang, Q., & Floyd-Smith, G. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.1385 · Cited by 26
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Finter, N. B. (1996) · The Lancet · doi:10.1016/s0140-6736(05)64985-9 · Cited by 24
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Squire, J. A., MEURS, E. F., Chong, K. L., McMillan, N. A. J., Hovanessian, A. G., & Williams, B. R. G. (1993) · Genomics · doi:10.1006/geno.1993.1263 · Cited by 24
Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase
Mellor, H., Flowers, K. M., Kimball, S. R., et al. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90229-1 · Cited by 24
Interferon-regulated human 2–5A synthetase gene maps to chromosome 12
Williams, B., Saunders, M. E., & Willard, H. F. (1986) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01570735 · Cited by 23
Adenovirus-Mediated Gene Expression In Vivo Is Enhanced by the Antiapoptotic Bcl-2 Gene
Bilbao, G., Contreras, J. L., Zhang, H., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6992-7000.1999 · Cited by 23
Role of the RNA-dependent protein kinase in the regulated expression of genes in transfected cells
Samuel, C. E. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90005-k · Cited by 22
Self-citation
A novel translational regulation function for the simian virus 40 large-T antigen gene
Rajan, P., Swaminathan, S., Zhu, J., Cole, C. N., Barber, G. N., Tevethia, M. J., & Thimmapaya, B. (1995) · Journal of Virology · doi:10.1128/jvi.69.2.785-795.1995 · Cited by 21
Isolation and Characterization of a New Mutant Human Cell Line Unresponsive to Alpha and Beta Interferons
John, J., McKendry, R., Pellegrini, S., et al. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.4189-4195.1991 · Cited by 21
Inhibition of influenza C viruses by human MxA protein
Marschall, M., Zach, A., Hechtfischer, A., et al. (2000) · Virus Research · doi:10.1016/s0168-1702(00)00140-4 · Cited by 20
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Self-citation
Bass, B. L. et al. A standardized nomenclature for adenosine deaminases that act on RNA. RNA 3, 947-949
Bass, B., Nishikura, K., Keller, W. D., et al. (1997) · Cited by 19
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Benech, P. D., Vigneron, M., Peretz, D., et al. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.12.4498-4504.1987 · Cited by 19
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Self-citation
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Self-citation
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Dessens, J. T., & Nuttall, P. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.10.8362-8364.1998 · Cited by 15
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Self-citation
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Weier, H.-U. G., George, C. X., Lersch, R., et al. (2000) · Cytogenetic and Genome Research · doi:10.1159/000015615 · Cited by 11
Hepatitis C Virus Dynamics In Vivo And the Antiviral Efficacy of Interferon Alfa Therapy
Thomas, H. C., Török, M. E., & Foster, G. R. (1999) · Hepatology · doi:10.1002/hep.510290453 · Cited by 10
(2′‐5′)An‐dependent endoribonuclease: Enzyme levels are regulated by IFNβ, IFNγ, and cell culture conditions
Floyd-Smith, G. (1988) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240380103 · Cited by 9
Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene
Blanchard, A. D., Page, K. R., Watkin, H., Hayward, P., Wong, T., Bartholomew, M. A., Quint, D. J., Daly, M. G., Garcia-Lopez, J., & CHAMPION, B. R. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200011)30:11 · Cited by 9
ANTICELLULAR AND ANTIVIRAL EFFECTS OF PPPA(2′P5′A)N
Hovanessian, A. G., Wood, J. N., MEURS, E. F., et al. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb20682.x · Cited by 8
Mechanism of interferon action Sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones
Kuhen, K., Shen, X., & Samuel, C. E. (1996) · Gene · doi:10.1016/0378-1119(96)00314-9 · Cited by 6
Self-citation
A (2′-5′)A n -Dependent Endonuclease: Tissue Distribution in BALB/c Mice and the Effects of IFN-β Treatment and Anti-IFN-α/β Immunoglobulin on the Levels of the Enzyme
Floyd-Smith, G., & Denton, J. (1988) · Journal of Interferon Research · doi:10.1089/jir.1988.8.517 · Cited by 6

Research works printed but not linked: 3

Knipe D. M. Howley P. M. Griffin D. E. Martin M. Roizman B. Straus S. E. Fields virology 4th ed. 2001 Lippincott-Raven Philadelphia Pa
10.1016/0042-6822(92)90733-6 · DOI
Nagano Y. Kojima Y. Inhibition de I'infection vaccinale par le virus homologue. C. R. Seances Soc. Biol. Fil. 152 1958 1627 1630

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Authors: Samuel, C. E.
Affiliations: University of California, Santa Barbara (US)
Corresponding author: Samuel, Charles E.
ORCID: Samuel, Charles E.
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2001-10
Volume: 14
Issue: 4
Pages: 778-809
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.14.4.778-809.2001
PMC: PMC89003
OpenAlex: W2160063406
Cited by: 2,743
References: 474
Citations by year: 2026: 42 · 2025: 64 · 2024: 81 · 2023: 93 · 2022: 105 · 2021: 157 · 2020: 166 · 2019: 67 · 2018: 60 · 2017: 61 · 2016: 78 · 2015: 89 · 2014: 116 · 2013: 108 · 2012: 140
FWCI: 7.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI-20611, R01AI012520, AI 12520, R37AI012520, R01AI020611)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: interferon, antiviral mechanism, interferon-induced proteins, PKR, 2',5'-oligoadenylate synthetase, RNase L, ADAR1, double-stranded RNA, inducible nitric oxide synthase, MHC class I and II, JAK/STAT signaling, interferon receptor, interferon-gamma, host-virus interaction, interferon therapy
MeSH terms: Antiviral Agents, Humans, Interferons, Virus Diseases, Signal Transduction, Transcriptional Activation, Apoptosis, Receptors, Interferon

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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Antiviral Actions of Interferons

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