The DOI matches its Crossref record; 297 of the 297 references it cites were found in a registry or an index.
Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research
Open accessAbstract
SUMMARY: Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes. Genital herpes is a major risk factor for human immunodeficiency virus type 1 transmission. Considerable efforts have been made to design and test vaccines for HSV, focusing on genital infection with HSV-2. Several protein subunit vaccines based on HSV-2 envelope glycoproteins have reached advanced-phase clinical trials. These antigens were chosen because they are the targets of neutralizing-antibody responses and because they elicit cellular immunity. Encouraging results have been reported in studies of treatment of HSV-seronegative women with a vaccine consisting of truncated glycoprotein D of HSV-2 and a novel adjuvant. Because most sexual HSV transmission occurs during asymptomatic shedding, it is important to evaluate the impact of vaccination on HSV-2 infection, clinically apparent genital herpes, and HSV shedding among vaccine recipients who acquire infection. There are several other attractive formats, including subunit vaccines that target cellular immune responses, live attenuated virus strains, and mutant strains that undergo incomplete lytic replication. HSV vaccines have also been evaluated for the immunotherapy of established HSV infection.
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“Furthermore, recent breakthroughs in the field of HSV-1 technology authorize and support the use of HSV-1 as vaccine vectors for the delivery of foreign antigens.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [116]
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1 retracted
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The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
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Cited by
Sorted by citations
Ghosh, S., Brown, A. M., Jenkins, C., & Campbell, K. (2020) · Applied Biosafety · doi:10.1177/1535676019899502 · Cited by 218
Hedrick, S. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.020 · Cited by 122
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Metadata
- Authors
- Koelle, D. M., & Corey, L.
- Affiliations
- University of Washington (US)
- Corresponding author
- Koelle, David M.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2003-01
- Volume
- 16
- Issue
- 1
- Pages
- 96-113
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC145296
- OpenAlex
- W2158636026
- Cited by
- 263
- References
- 297
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 16
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R21AI050132, AI 30731, P01AI030731, R01AI050132, AI 50132)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- herpes simplex virus, herpes simplex virus type 1, herpes simplex virus type 2, herpes vaccine, subunit vaccine, glycoproteins, glycoprotein D, adjuvants, genital herpes, neonatal herpes, HIV transmission, asymptomatic viral shedding, live attenuated vaccine, cell-mediated immunity, neutralizing antibodies
- MeSH terms
- Forecasting, Herpes Simplex, Humans, Viral Vaccines, Simplexvirus
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