Cited by 122Evolution and Genetic DynamicsImmune Response and InflammationInvertebrate Immune Response Mechanisms

The Acquired Immune System

Open access
Hedrick, Stephen M.·2004·Immunity

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2004.08.020

Cites

81 of 81 references verified0 citation errors · 0 not checkable

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  • Potential immunogenic signals from dying cells include surface-exposed proteins such as calreticulin and heat shock proteins, lipid moieties such as phosphatidylserine that flip to the outer leaflet, released proteins such as HMGB1, and extracellular nucleic acids and their degradation products (oligonucleotides, nucleotides, nucleosides, urate).

    “Potential immunogenic signals emanating from dying cells include proteins that appear at the surface of stressed and dying cells (such as calreticulin and heat shock proteins, HSPs), lipid moieties that flip from the inner plasma membrane leaflet to the outer leaflet (such as phosphatidylserine) 38,60, proteins that are released into the supernatant of cells (such as HMGB1) 51, as well as nucleic”

    From Immunogenic and tolerogenic cell death (2009) · cites this paper as [105]

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Authors
Hedrick, S. M.
Venue
Immunity
Publisher
Elsevier BV
Published
2004-11
Volume
21
Issue
5
Pages
607-615
ISSN
1074-7613 (ISSN-L)
OpenAlex
W46020760
Cited by
122
References
85
Citations by year
2026: 5 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 4
FWCI
0.72
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords
adaptive immunity, innate immunity, host-parasite coevolution, parasitism, host variation, immune system evolution, infectious agents, immune evasion
MeSH terms
Animals, Biological Evolution, Host-Parasite Interactions, Humans, Immune System, Immunity, Infections, Invertebrates, Virulence

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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