The Acquired Immune System
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Potential immunogenic signals from dying cells include surface-exposed proteins such as calreticulin and heat shock proteins, lipid moieties such as phosphatidylserine that flip to the outer leaflet, released proteins such as HMGB1, and extracellular nucleic acids and their degradation products (oligonucleotides, nucleotides, nucleosides, urate).
“Potential immunogenic signals emanating from dying cells include proteins that appear at the surface of stressed and dying cells (such as calreticulin and heat shock proteins, HSPs), lipid moieties that flip from the inner plasma membrane leaflet to the outer leaflet (such as phosphatidylserine) 38,60, proteins that are released into the supernatant of cells (such as HMGB1) 51, as well as nucleic”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [105]
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- Authors
- Hedrick, S. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 21
- Issue
- 5
- Pages
- 607-615
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W46020760
- Cited by
- 122
- References
- 85
- Citations by year
- 2026: 5 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 4
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- adaptive immunity, innate immunity, host-parasite coevolution, parasitism, host variation, immune system evolution, infectious agents, immune evasion
- MeSH terms
- Animals, Biological Evolution, Host-Parasite Interactions, Humans, Immune System, Immunity, Infections, Invertebrates, Virulence
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