The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Biological safety cabinetry
Open accessAbstract
The biological safety cabinet is the one piece of laboratory and pharmacy equipment that provides protection for personnel, the product, and the environment. Through the history of laboratory-acquired infections from the earliest published case to the emergence of hepatitis B and AIDS, the need for health care worker protection is described. A brief description with design, construction, function, and production capabilities is provided for class I and class III safety cabinets. The development of the high-efficiency particulate air filter provided the impetus for clean room technology, from which evolved the class II laminar flow biological safety cabinet. The clean room concept was advanced when the horizontal airflow clean bench was manufactured; it became popular in pharmacies for preparing intravenous solutions because the product was protected. However, as with infectious microorganisms and laboratory workers, individual sensitization to antibiotics and the advent of hazardous antineoplastic agents changed the thinking of pharmacists and nurses, and they began to use the class II safety cabinet to prevent adverse personnel reactions to the drugs. How the class II safety cabinet became the mainstay in laboratories and pharmacies is described, and insight is provided into the formulation of National Sanitation Foundation standard number 49 and its revisions. The working operations of a class II cabinet are described, as are the variations of the four types with regard to design, function, air velocity profiles, and the use of toxins. The main certification procedures are explained, with examples of improper or incorrect certifications. The required levels of containment for microorganisms are given. Instructions for decontaminating the class II biological safety cabinet of infectious agents are provided; unfortunately, there is no method for decontaminating the cabinet of antineoplastic agents.
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Cites
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Metadata
- Authors
- Kruse, R. H., Puckett, W. H., & Richardson, J. H.
- Affiliations
- MEDI, Inc., Lexington, Kentucky 40576-1486.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 1991-04
- Volume
- 4
- Issue
- 2
- Pages
- 207-241
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC358192
- OpenAlex
- W1912337695
- Cited by
- 81
- References
- 149
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Safe Handling of Antineoplastic Drugs
- Physical Sciences › Chemical Engineering › Chemical Health and Safety › Chemical Safety and Risk Management
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- biological safety cabinet, laboratory-acquired infection, hepatitis B, AIDS, HEPA filters, pharmaceutical compounding, anticancer agents, air velocity profiles
- MeSH terms
- Acquired Immunodeficiency Syndrome, Atmosphere Exposure Chambers, Containment of Biohazards, Hepatitis B, Humans, Laboratory Infection, Tuberculosis
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- Kruse, R. H., Puckett, W. H., & Richardson, J. H. (1991). Biological safety cabinetry. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.4.2.207
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
