The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Clostridium difficile: clinical disease and diagnosis
Open accessAbstract
Clostridium difficile is an opportunistic pathogen that causes a spectrum of disease ranging from antibiotic-associated diarrhea to pseudomembranous colitis. Although the disease was first described in 1893, the etiologic agent was not isolated and identified until 1978. Since clinical and pathological features of C. difficile-associated disease are not easily distinguished from those of other gastrointestinal diseases, including ulcerative colitis, chronic inflammatory bowel disease, and Crohn's disease, diagnostic methods have relied on either isolation and identification of the microorganism or direct detection of bacterial antigens or toxins in stool specimens. The current review focuses on the sensitivity, specificity, and practical use of several diagnostic tests, including methods for culture of the etiologic agent, cellular cytotoxicity assays, latex agglutination tests, enzyme immunoassay systems, counterimmunoelectrophoresis, fluorescent-antibody assays, and polymerase chain reactions.
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Cites
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia
Bartlett, J. G., Chang, T. W., Gurwith, M., Gorbach, S. L., & Onderdonk, A. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197803092981003 · Cited by 1,374
Clostridia isolated from the feces of infants during the first year of life
Stark, P. L., & Lee, A. (1982) · The Journal of Pediatrics · doi:10.1016/s0022-3476(82)80430-7 · Cited by 80
Cited by
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
van Prehn, J., Reigadas, E., Vogelzang, E. H., Bouza, E., Hristea, A., Guery, B., Krutova, M., Norén, T., Allerberger, F., Coia, J. E., et al. (2021) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2021.09.038 · Cited by 640
Clostridium Difficile-Associated Diarrhea and Colitis
Gerding, D. N., Johnson, S., Peterson, L. R., Mulligan, M. E., & Silva, J. (1995) · Infection Control & Hospital Epidemiology · doi:10.1086/648363 · Cited by 631
Clostridium difficile-Associated Diarrhea and Colitis
Gerding, D. N., Johnson, S., Peterson, L. R., Mulligan, M. E., & Silva, J. (1995) · Infection Control and Hospital Epidemiology · doi:10.2307/30141083 · Cited by 398
Rupnik, M., Avesani, V., Janc, M., von Eichel-Streiber, C., & Delmée, M. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.8.2240-2247.1998 · Cited by 323
Metadata
- Authors
- Knoop, F. C., Owens, M., & Crocker, I. C.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 1993-07
- Volume
- 6
- Issue
- 3
- Pages
- 251-265
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2132039569
- Cited by
- 171
- References
- 2
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- green
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