Clostridia isolated from the feces of infants during the first year of life

Stark, P.L.; Lee, Adrian

doi:10.1016/s0022-3476(82)80430-7

Cited by 80Clostridium difficile and Clostridium perfringens researchGut microbiota and healthInfant Nutrition and Health

Clostridia isolated from the feces of infants during the first year of life

Stark, P.L., Lee, Adrian·1982·The Journal of Pediatrics

DOI 10.1016/s0022-3476(82)80430-7

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Abstract

Clostridia isolated from the feces of ten healthy infants during the first year of life were identified. All infants excreted clostridia during the first week of life; the most common species were Clostridium butyricum, C. paraputrificum, and C. difficile. In the formula-fed infants colonization occurred consistently throughout the year, whereas in some breast-fed infants it was inhibited until weaning. The species isolated most frequently throughout the year were C. paraputrificum, C. butyricum, C. ramosum, C. sartagoformum, and C. perfringens. Of the species often found in infants, C. butyricum, C. difficile, and C. sartagoformum occur rarely in adults, reflecting differences in the environmental conditions in the gut of the two age groups. The mechanism by which environmental conditions select species of clostridia is unknown but may be important to our understanding of a variety of clostridial intestinal infections. It was demonstrated that species of clostridia which have been implicated in the etiology of neonatal necrotizing enterocolitis form part of the normal infant gastrointestinal microflora.

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Multiple studies show decreased Clostridia colonization in breast-fed infants, including colonization with Clostridium difficile.
“multiple studies have shown a decrease in Clostridia colonization of breast-fed infants19, 20 including colonization with Clostridium difficile 21.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [19]

Anaerobe Laboratory manual
Holdeman, L. V., Moore, W. E., & Cato, E. P. (1977) · Cited by 3,045 · see citing works
INTESTINAL FLORA IN NEW-BORN INFANTS
Hall, I. C. (1935) · American journal of diseases of children · doi:10.1001/archpedi.1935.01970020105010 · Cited by 766 · see citing works
Selective and differential medium for isolation of Clostridium difficile
George, W. L., Sutter, V. L., Citron, D. M., & Finegold, S. M. (1979) · Journal of Clinical Microbiology · doi:10.1128/jcm.9.2.214-219.1979 · Cited by 616 · see citing works
The Microbial Ecology of the Large Bowel of Breastfed and Formula-fed Infants During the First Year of Life
Stark, P. L., & Lee, A. (1982) · Journal of Medical Microbiology · doi:10.1099/00222615-15-2-189 · Cited by 616 · see citing works
Self-citation
MATERNAL DEATHS
Newcombe, R. G. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90482-1 · Cited by 546 · see citing works
Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis
Bartlett, J. G., Moon, N. I., Chang, T.-W., Taylor, N. S., & Onderdonk, A. B. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90457-2 · Cited by 507 · see citing works
Some current concepts in intestinal bacteriology
Moore, W., Cato, E., & Holdeman, L. V. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.10.s33 · Cited by 256 · see citing works
OUTBREAK OF NECROTISING ENTEROCOLITIS CAUSED BY CLOSTRIDIUM BUTYRICUM
Howard, F. M., Bradley, J., Flynn, D., Noone, P., & Szawatkowski, M. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90546-3 · Cited by 155 · see citing works
Infant botulism. Epidemiological, clinical, and laboratory aspects
Arnon, S. S. (1977) · JAMA · doi:10.1001/jama.237.18.1946 · Cited by 155 · see citing works
Infant Botulism
Arnon, S. S. (1977) · JAMA · doi:10.1001/jama.1977.03270450036016 · Cited by 124 · see citing works
Degradation of steroids by intestinal bacteria
Goddard, P., & Hill, M. J. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90101-4 · Cited by 108 · see citing works
Transport and Storage of Faeces for Bacteriological Examination
Crowther, J. S. (1971) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1971.tb02307.x · Cited by 103 · see citing works
Some new media for the isolation and identification of clostridia
Willis, A. T., & Hobbs, G. (1959) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700770223 · Cited by 88 · see citing works
Clostridia colonization and clostridial toxin in neonatal necrotizing enterocolitis
Cashore, W. J., Peter, G., Lauermann, M. W., Stonestreet, B. S., & Oh, W. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80667-1 · Cited by 80 · see citing works
Clostridia isolated from faeces
Drašar, B. S., Goddard, P., Heaton, S., Peach, S., & West, B. (1976) · Journal of Medical Microbiology · doi:10.1099/00222615-9-1-63 · Cited by 80 · see citing works
Degradation of steroids by intestinal bacteria. III. 3-OXO-5β-steroid Δ1-dehydrogenase and 3-OXO-5β-steroid Δ4-dehydrogenase
Aries, V. C., Goddard, P., & Hill, M. J. (1971) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(71)90238-4 · Cited by 58 · see citing works
NEONATAL NECROTISING ENTEROCOLITIS
Kindley, A. D., Roberts, P. J., & Tulloch, W. H. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92082-7 · Cited by 51 · see citing works
The isolation of Clostridium perfringens type C from necrotic enteritis of man in Papua‐New Guinea
Egerton, J. R., & Walker, P. D. (1964) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700880134 · Cited by 40 · see citing works
CLOSTRIDIUM BUTYRICUM AND NECROTISING ENTEROCOLITIS
Gothefors, L., & Blenkharn, J. I. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90406-3 · Cited by 34 · see citing works
Development of a Micromethod for Identification of Anaerobic Bacteria
Wilkins, T. D., & Walker, C. (1975) · Applied Microbiology · doi:10.1128/am.30.5.825-830.1975 · Cited by 29 · see citing works
ADRIAMYCIN IN ADVANCED BREAST CANCER
Edelstyn, G. A., & MacRae, K. D. (1976) · The Lancet · doi:10.1016/s0140-6736(76)90467-0 · Cited by 25 · see citing works
ICMSF methods studies. VIII. Comparative study for the enumeration of Clostridium perfringens in foods
Hauschild, A. H. W., Rj, G., Harmon, S. M., O'Keeffe, M. F., & Vahlefeld, R. (1977) · Canadian Journal of Microbiology · doi:10.1139/m77-130 · Cited by 22 · see citing works
Case of infant botulism in Texas.
Bj, E., Guerra, F. A., Blake, J., & Hempler, S. (1977) · PubMed · Cited by 19 · see citing works
Development of a Selective Medium for the Isolation of Clostridium sporogenes and Related Organisms
Fryer, T. F., & Mead, G. C. (1979) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1979.tb01203.x · Cited by 11 · see citing works
Development of a Micromethod for Identification of Anaerobic Bacteria
Wilkins, T. D., & Walker, C. (1975) · Applied Microbiology · doi:10.1128/aem.30.5.825-830.1975 · Cited by 11 · see citing works
Isolation of Toxin Producing Clostridium difficile from Two Children with Oxacillin- and Dicloxacillin-Associated Diarrhea
Brook, I. (1980) · PEDIATRICS · doi:10.1542/peds.65.6.1154 · Cited by 10 · see citing works
ICMSF methods studies. XII. Comparative study for the enumeration of Clostridium perfringens in feces
Hauschild, A. H. W., Desmarchelier, P. M., Rj, G., Harmon, S. M., & Vahlefeld, R. (1979) · Canadian Journal of Microbiology · doi:10.1139/m79-146 · Cited by 8 · see citing works

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Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., Dubberke, E. R., Garey, K. W., Gould, C. V., Kelly, C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1085 · Cited by 2,690 · see citing works
Clostridial enteric diseases of domestic animals
Songer, J. G. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.2.216 · Cited by 913 · see citing works
Development of the gut microbiota in infancy and its impact on health in later life
Tanaka, M., & Nakayama, J. (2017) · Allergology International · doi:10.1016/j.alit.2017.07.010 · Cited by 639 · see citing works
Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606 · see citing works
The Intestinal Microflora of Infants: Composition of Fecal Flora in Breast‐Fed and Bottle‐Fed Infants
Benno, Y., Sawada, K., & MITSUOKA, T. (1984) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1984.tb00754.x · Cited by 432 · see citing works
Neonatal necrotizing enterocolitis: Pathogenesis, classification, and spectrum of illness
Kliegman, R. M., & Walsh, M. C. (1987) · Current Problems in Pediatrics · doi:10.1016/0045-9380(87)90031-4 · Cited by 418 · see citing works
Necrotizing Enterocolitis
Kliegman, R. M., & Fanaroff, A. A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404263101707 · Cited by 372 · see citing works
Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning?
Kirjavainen, P. V., Arvola, T., Salminen, S., & Isolauri, E. (2002) · Gut · doi:10.1136/gut.51.1.51 · Cited by 354 · see citing works
Asymptomatic Colonization by Clostridium difficile in Infants: Implications for Disease in Later Life
Jangi, S., & LaMont, J. T. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d29767 · Cited by 306 · see citing works
Probiotic Bacteria in the Management of Atopic Disease: Underscoring the Importance of Viability
Kirjavainen, P. V., Salminen, S., & Isolauri, E. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200302000-00012 · Cited by 262 · see citing works
Clostridium difficile infection
Vedantam, G., Clark, A. E., Chu, M., McQuade, R., Mallozzi, M., & Viswanathan, V. K. (2012) · Gut Microbes · doi:10.4161/gmic.19399 · Cited by 210 · see citing works
Clostridium difficile – From Colonization to Infection
Schäffler, H., & Breitrück, A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00646 · Cited by 174 · see citing works
Diaper Dermatitis: Frequency and Severity Among a General Infant Population
Jordan, W. E., Lawson, K. D., Berg, R. W., Franxman, J. J., & Marrer, A. M. (1986) · Pediatric Dermatology · doi:10.1111/j.1525-1470.1986.tb00513.x · Cited by 174 · see citing works
Clostridium difficile: clinical disease and diagnosis
Knoop, F. C., Owens, M. J., & Crocker, I. C. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.3.251 · Cited by 166 · see citing works
Infectious Causes of Necrotizing Enterocolitis
Coggins, S. A., Wynn, J. L., & Weitkamp, J.-H. (2014) · Clinics in Perinatology · doi:10.1016/j.clp.2014.10.012 · Cited by 129 · see citing works
Clostridium difficile Infection in Children
Sammons, J. S., Toltzis, P., & Zaoutis, T. E. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.441 · Cited by 125 · see citing works
Risk Factors for Infant Botulism in the United States
Spika, J. S. (1989) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1989.02150190078026 · Cited by 119 · see citing works
Intestinal Flora of Infants
Cooperstock, M. S., & Zedd, A. J. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50010-0 · Cited by 117 · see citing works
Clostridium difficileinfection
Viswanathan, V. K., Mallozzi, M., & Vedantam, G. (2010) · Gut Microbes · doi:10.4161/gmic.1.4.12706 · Cited by 109 · see citing works
Clostridium difficile in children: Colonisation and disease
Enoch, D., Butler, M. J., Pai, S., Aliyu, S. H., & Karas, J. A. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.05.016 · Cited by 102 · see citing works
Infant Botulism Acquired from Household Dust Presenting as Sudden Infant Death Syndrome
Nevas, M., Lindström, M., Virtanen, A., Hielm, S., Kuusi, M., Arnon, S. S., Vuori, E., & Korkeala, H. J. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.1.511-513.2005 · Cited by 100 · see citing works
The impact of perinatal probiotic intervention on gut microbiota: Double-blind placebo-controlled trials in Finland and Germany
Grześkowiak, Ł., Grönlund, M., Beckmann, C., Salminen, S., Berg, A. V., & Isolauri, E. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.09.006 · Cited by 85 · see citing works
An Outbreak of Necrotizing Enterocolitis Associated with a NovelClostridiumSpecies in a Neonatal Intensive Care Unit
Alfa, M. J., Robson, D., Davi, M., Bernard, K., Caeseele, P. G. V., & Harding, G. K. M. (2002) · Clinical Infectious Diseases · doi:10.1086/341929 · Cited by 79 · see citing works
Acute necrotizing enterocolitis of preterm piglets is characterized by dysbiosis of ileal mucosa-associated bacteria
Azcarate-Peril, M. A., Foster, D. M., Cadenas, M. B., Stone, M. R., Jacobi, S. K., Stauffer, S. H., Pease, A., & Gookin, J. L. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16332 · Cited by 77 · see citing works
Infant Botulism: Anticipating the Second Decade
Arnon, S. S. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.2.201 · Cited by 72 · see citing works
The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life
Kaczmarczyk, M., Löber, U., Adamek, K., Węgrzyn, D., Skonieczna‐Żydecka, K., Malinowski, D., Łoniewski, I., Markó, L., Ulas, T., Forslund, S. K., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02839-w · Cited by 68 · see citing works
Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood
Tanaka, M., Korenori, Y., Washio, M., Kobayashi, T., Momoda, R., Kiyohara, C., Kuroda, A., Saito, Y., Sonomoto, K., & Nakayama, J. (2017) · FEMS Microbiology Ecology · doi:10.1093/femsec/fix099 · Cited by 66 · see citing works
The Clostridium ramosum IgA Proteinase Represents a Novel Type of Metalloendopeptidase
Kosowska, K., Reinholdt, J., Rasmussen, L. K., Sabat, A. J., Potempa, J., Kilian, M., & Poulsen, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110883200 · Cited by 63 · see citing works
Clostridium difficile in Patients With Cystic Fibrosis
Welkon, C. J. (1985) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1985.02140100067032 · Cited by 57 · see citing works
In Vitro and in Vivo Neutralizing Activity of Human Colostrum and Milk Against Purified Toxins A and B of Clostridium difficile
Kim, K., Pickering, L. K., DuPont, H. L., Sullivan, N. M., & Wilkins, T. D. (1984) · The Journal of Infectious Diseases · doi:10.1093/infdis/150.1.57 · Cited by 57 · see citing works
Clostridium difficile Cytotoxin in a Pediatric Population
Thompson, C. M. (1983) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1983.02140290057015 · Cited by 56 · see citing works
Clostridium ramosum, an IgA Protease‐Producing Species and Its Ecology in the Human Intestinal Tract
Senda, S., Fujiyama, Y., Ushijima, T., Hodohara, K., Bamba, T., Hosoda, S., & Kobayashi, K. (1985) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1985.tb00892.x · Cited by 55 · see citing works
Presence of Soil-Dwelling Clostridia in Commercial Powdered Infant Formulas
Barash, J. R., Hsia, J. K., & Arnon, S. S. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.09.072 · Cited by 52 · see citing works
Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights
Kiu, R., Caim, S., Alcon-Giner, C., Bélteki, G., Clarke, P., Pickard, D., Gordon Dougan, B., & Hall, L. J. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx210 · Cited by 49 · see citing works
Gut Microbiota in Nutrition and Health with a Special Focus on Specific Bacterial Clusters
Bresser, L. R. F., de Goffau, M. C., Levin, E., & Nieuwdorp, M. (2022) · Cells · doi:10.3390/cells11193091 · Cited by 39 · see citing works
Is Clostridium difficile pathogenic in infants?
Welch, D. F., & Marks, M. I. (1982) · The Journal of Pediatrics · doi:10.1016/s0022-3476(82)80436-8 · Cited by 36 · see citing works
Hallmarks of the human intestinal microbiome on liver maturation and function
Almeida, J. I., Tenreiro, M. F., Martínez‐Santamaría, L., Guerrero‐Aspizua, S., Gisbert, J. P., Alves, P. M., Serra, M., & Baptista, P. M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.10.015 · Cited by 37 · see citing works
Infant Botulism
Wigginton, J. M., & Thill, P. (1993) · Clinical Pediatrics · doi:10.1177/000992289303201105 · Cited by 33 · see citing works
Clostridium innocuum: a glucoseureide-splitting inhabitant of the human intestinal tract
Mohr, C., Heine, W. E., & Wutzke, K. D. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00162-2 · Cited by 32 · see citing works
Breast Feeding and Toxigenic Intestinal Infections: Missing Links in Crib Death?
Amon, S. S. (1984) · Clinical Infectious Diseases · doi:10.1093/clinids/6.supplement_1.s193 · Cited by 32 · see citing works
A hypothesis concerning Clostridium perfringens type A enterotoxin (CPE) and Sudden Infant Death Syndrome (SIDS)
Murrell, T. G. C., Ingham, B. G., Moss, J., & Taylor, W. B. (1987) · Medical Hypotheses · doi:10.1016/0306-9877(87)90035-1 · Cited by 31 · see citing works
Spondylodiscitis Due to Clostridium ramosum Infection in an Immunocompetent Elderly Patient
Lavigne, J., Bouziges, N., Sotto, A., Leroux, J., & Michaux‐Charachon, S. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.5.2223-2226.2003 · Cited by 29 · see citing works
Human Microbiome: age-related changes and functions
Kaybysheva, V. O., Zharova, M. E., Filimendikova, K. Y., & Nikonov, E. L. (2020) · Russian Journal of Evidence-Based Gastroenterology · doi:10.17116/dokgastro2020902142 · Cited by 31 · see citing works
Digestive Endoscopy in Neonates
Dupont, C. M., Kalach, N., Boissieu, D. D., Barbet, P., & Benhamou, P. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000153098.80706.fa · Cited by 24 · see citing works
Hospital-Acquired Clostridium difficile Infection amongst ICU and Burn Patients in Kuwait
Rotimi, V. O., Mokaddas, E. M., Jamal, W. Y., Verghese, T., El-Din, K., & Junaid, T. A. (2002) · Medical Principles and Practice · doi:10.1159/000048656 · Cited by 23 · see citing works
Use of the lactose-[13C]ureide breath test for diagnosis of small bowel bacterial overgrowth: comparison to the glucose hydrogen breath test
Berthold, H. K., Schober, P. R., Scheurlen, C., Marklein, G., Horré, R., Gouni‐Berthold, I., & Sauerbruch, T. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0097-8 · Cited by 22 · see citing works
Infant botulism: an underestimated threat
Antonucci, L., Locci, C., Schettini, L., Clemente, M. G., & Antonucci, R. (2021) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2021.1919753 · Cited by 25 · see citing works
Detection of Clostridium difficile toxin A and B genes from stool samples of Thai diarrheal patients by polymerase chain reaction technique.
Wongwanich, S., Rugdeekha, S., Pongpech, P., & Dhiraputra, C. (2003) · PubMed · Cited by 20 · see citing works
The Intestinal Microflora of Infants: Fecal Flora of Infants with Vitamin K Deficiency
Benno, Y., Sawada, K., & MITSUOKA, T. (1985) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1985.tb00823.x · Cited by 18 · see citing works
Prospective study ofClostridium difficilecolonization and para-cresol detection in the stools of babies on a special care unit
Phua, T. J., Rogers, T. R., & Pallett, A. (1984) · Journal of Hygiene · doi:10.1017/s0022172400060885 · Cited by 16 · see citing works
Clostridium paraputrificum Bacteremia in an Older Patient with No Predisposing Medical Condition
Fukui, M., Iwai, S., SAKAMOTO, R., Takahashi, H., Hayashi, T., & Kenzaka, T. (2017) · Internal Medicine · doi:10.2169/internalmedicine.8164-16 · Cited by 15 · see citing works
Clostridium Diffi cile-Associated Diarrhea in a Pediatric Hospital
Spivack, J. G., Eppes, S. C., & Klein, J. D. (2003) · Clinical Pediatrics · doi:10.1177/000992280304200407 · Cited by 14 · see citing works
Infant Botulism
Arnon, S. S. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-256745-2.50032-5 · Cited by 11 · see citing works
Clostridium-difficile-assoziierte Infektionen im Kindes- und Jugendalter
Weichert, S., Simon, A., von Müller, L., Adam, R., & Schroten, H. (2015) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-014-3253-z · Cited by 10 · see citing works
Sudden-Infant-Death Syndrome
(1982) · New England Journal of Medicine · doi:10.1056/nejm198209303071413 · Cited by 9 · see citing works
Infant botulism: First two confirmed cases in Slovenia and literature review
Radšel, A., Andlovic, A., Neubauer, D., & Osredkar, D. (2013) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2013.04.009 · Cited by 8 · see citing works
Effect of Diet and Aging on Human Fecal Microflora
Benno, Y., & MITSUOKA, T. (1991) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.10.2_89 · Cited by 7 · see citing works
Clostridium difficile in Infants and Children
Cooperstock, M. S. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-593410-7.50008-9 · Cited by 6 · see citing works
Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome
Lubin, J., Silverman, M. A., & Planet, P. J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2387875 · Cited by 5 · see citing works
Development of a 16S rRNA-based Probe forClostridium ramosum, C. spiroformeandC. cocleatumand its Application for the Quantification in Human Faeces from Volunteers of Different Age Groups
Wildeboer-Veloo, A. C. M., Harmsen, H. J. M., Degener, J. E., & Welling, G. W. (2003) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v15i2-3.7969 · Cited by 5 · see citing works
Development of a 16S rRNA-based Probe forClostridium ramosum,C. spiroformeandC. cocleatumand its Application for the Quantification in Human Faeces from Volunteers of Different Age Groups
Wildeboer-Veloo, A. C. M., Harmsen, H. J. M., Degener, J. E., & Welling, G. W. (2003) · Microbial Ecology in Health and Disease · doi:10.1080/08910600310018823 · Cited by 5 · see citing works
Clostridium botulinum in honey production with respect to infant botulism
Nevas, M. (2006) · Työväentutkimus Vuosikirja · Cited by 5 · see citing works
Diarrheal Disease in the Hospitalized Patient
Gilligan, P. H. (1986) · Infection Control · doi:10.1017/s0195941700065474 · Cited by 5 · see citing works
Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens
Huertas‐Díaz, L., Vestergaard, L. G., Marietou, A., Irla, M., Behr, J., Somoza, M. M., Feilberg, A., & Schwab, C. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00689-1 · Cited by 4 · see citing works
Infant napkin dermatitis
HOLDEN, C. E. A. (1998) · Journal of Wound Care · doi:10.12968/jowc.1998.7.8.417 · Cited by 4 · see citing works
Cleavage of L-leucine-containing dipeptides by Clostridium butyricum
Khelifa, N., Brik, M. E., Tessèdre, A., de ROCQUIGNY, H., Roques, B. P., Courtieu, J. M., & Rimbault, A. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00694-5 · Cited by 3 · see citing works
Review of updated clinical practice guidelines of the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) for Clostridium difficile infection in adults and children (2017)
Kozlov, R. S., Shelygin, Y. A., Veselov, A. V., Dekhnich, A. V., Zubareva, N., Ershova, O. N., Кулабухов, В. В., Попов, Д. А., Reshedko, G., & Yakushin, S. B. (2018) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2018.2.76-124 · Cited by 2 · see citing works
INFANT BOTULISM
Arnon, S. S. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4044-6.50164-3 · Cited by 2 · see citing works
Pediatric Clostridioides difficile Infection: Essential Concepts, Management Nuances, and Updates
Winkie, C., & Gisser, J. M. (2024) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-024-00310-8 · Cited by 1 · see citing works
Infant Botulism
Khouri, J. M., & Arnon, S. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-82763-8.00148-5 · Cited by 1 · see citing works
Diarrheal disease and DRGs
Gilligan, P. H. (1986) · Clinical Microbiology Newsletter · doi:10.1016/0196-4399(86)90096-6 · Cited by 1 · see citing works
Infant Botulism: a network to improve the diagnosis and treatment of a rare and under-diagnosed disease
Lonati, D., Locatelli, C., Bigi, S., Vecchio, S., Petrolini, V. M., Giampreti, A., Fenicia, L., Medici, D. D., & Manzo, L. (2008) · Emergency Care Journal · doi:10.4081/ecj.2008.6.35
Pneumatosis Cystoides Intestinalis in Gnotobiotic Quails.
Tanaka, M., Watanabe, K., Sugie, S., & Ueno, K. (1996) · Journal of Toxicologic Pathology · doi:10.1293/tox.9.131
Faculty Opinions recommendation of Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).
Dupont, A. W., & Khurana, S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732670634.793579191
Comparison of gnotobiotic communities reveals unexpected amino acid metabolism by the pre-weaning microbiomePreprint
Lubin, J., Silverman, M. A., & Planet, P. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.22.581588
Additional file 1 of The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life
Kaczmarczyk, M., Löber, U., Adamek, K., Węgrzyn, D., Skonieczna‐Żydecka, K., Malinowski, D., Łoniewski, I., Markó, L., Ulas, T., Forslund, S. K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14509527
Rewiring the brain: Ketogenic diet and gut microbiota in nervous system development
Jędrusik, J., & Setkowicz, Z. (2026) · Nutrition · doi:10.1016/j.nut.2026.113106
Clostridioides difficile in West Africa: a systematic review of the limited evidence and key knowledge gaps
Usuanlele, M.-T., Kabali, C., Mbuagbaw, L., Loeb, M. B., & Mertz, D. (2026) · Global Epidemiology · doi:10.1016/j.gloepi.2026.100281
Environmental Contamination of Pediatric Offices by Clostridioides difficile
Magence, A., Magence, T., Cadnum, J. L., Hailes, J. M., Donskey, C. J., & Toltzis, P. (2026) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piag093

Ecologia del genero clostridium en la flora fecal de neonatos y lactantes
Marcos, M. L. M. (1988) · Dialnet (Universidad de la Rioja)
Detection and Quantification of Four Species of the Genus Clostridium in Infant Feces
外岡, 俊., Sakata, S., Kitahara, M., Hanai, M., 石関, し., Takada, M., Sakamoto, M., & Benno, Y. (2005) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2005.tb03694.x · Cited by 39 · see citing works
Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study
Stark, P. L., Lee, A., & Parsonage, B. D. (1982) · Infection and Immunity · doi:10.1128/iai.35.3.895-899.1982 · Cited by 104 · see citing works
Self-citation
[Clostridium difficile and diarrhea in infants in the first half-year of life].
Rs, C., Dzhamali, N., Marina, M., Nv, M., Samsygina, G. A., SEMINA, N. A., & Tp, K. (1992) · PubMed · Cited by 1 · see citing works
Bifidobacterium, Bacteroides, and Clostridium spp. in fecal samples from breast-fed and bottle-fed infants with and without iron supplement
Mevissen-Verhage, E. A. E., Marcelis, J. H., Vos, M. D., Amerongen, W. C. M. H.-V., & Verhoef, J. (1987) · Journal of Clinical Microbiology · doi:10.1128/jcm.25.2.285-289.1987 · Cited by 95 · see citing works

Authors: Stark, P. L., & Lee, A.
Affiliations: UNSW Sydney (AU)
Corresponding author: Stark, P.L.
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 1982-03
Volume: 100
Issue: 3
Pages: 362-365
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/s0022-3476(82)80430-7
OpenAlex: W2053714425
Cited by: 80
References: 26
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2018: 3 · 2017: 5 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI: 5.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: Clostridium, infant gut microbiota, fecal colonization, Clostridium butyricum, Clostridium paraputrificum, Clostridium difficile, Clostridium perfringens, Clostridium ramosum, breastfeeding, bottle feeding, weaning, neonatal necrotizing enterocolitis
MeSH terms: Breast Feeding, Clostridium, Feces, Humans, Infant, Infant Food, Infant, Newborn, Prospective Studies

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Clostridia isolated from the feces of infants during the first year of life

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