The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Targeting the “Cytokine Storm” for Therapeutic Benefit
Open accessAbstract
Inflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacterium Francisella tularensis, do trigger life-threatening “cytokine storms” in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We review some of the current candidates for treatment of cytokine storms which may prove useful in the clinic in the future and compare them to more traditional therapeutic candidates that target the pathogen rather than the host response.
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Cites
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
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COVID-19 cytokine storm: the interplay between inflammation and coagulation
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Activation and evasion of type I interferon responses by SARS-CoV-2
Lei, X., Dong, X., Ma, R., Wang, W., Xiao, X., Tian, Z., Wang, C., Wang, Y., Li, L., Ren, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17665-9 · Cited by 980
Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients
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Yang, Y., Shen, C., Li, J., Yuan, J., Wei, J., Huang, F., Wang, F., Li, G., Li, Y., Xing, L., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.04.027 · Cited by 872
Metadata
- Authors
- D'Elia, R. V., Harrison, K., Oyston, P. C., Lukaszewski, R. A., & Clark, G. C.
- Venue
- Clinical and Vaccine Immunology
- Publisher
- American Society for Microbiology
- Published
- 2013-01-02
- Volume
- 20
- Issue
- 3
- Pages
- 319-327
- ISSN
- 1556-679X (ISSN-L)
- 1556-6811
- OpenAlex
- W2147453764
- Cited by
- 324
- References
- 103
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- diamond
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- D'Elia, R. V., Harrison, K., Oyston, P. C., Lukaszewski, R. A., & Clark, G. C. (2013). Targeting the “Cytokine Storm” for Therapeutic Benefit. Clinical and Vaccine Immunology. https://doi.org/10.1128/cvi.00636-12
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