The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
The ABCs of Candida albicans Multidrug Transporter Cdr1
Open accessAbstract
In the light of multidrug resistance (MDR) among pathogenic microbes and cancer cells, membrane transporters have gained profound clinical significance. Chemotherapeutic failure, by far, has been attributed mainly to the robust and diverse array of these proteins, which are omnipresent in every stratum of the living world. Candida albicans, one of the major fungal pathogens affecting immunocompromised patients, also develops MDR during the course of chemotherapy. The pivotal membrane transporters that C. albicans has exploited as one of the strategies to develop MDR belongs to either the ATP binding cassette (ABC) or the major facilitator superfamily (MFS) class of proteins. The ABC transporter Candida drug resistance 1 protein (Cdr1p) is a major player among these transporters that enables the pathogen to outplay the battery of antifungals encountered by it. The promiscuous Cdr1 protein fulfills the quintessential need of a model to study molecular mechanisms of multidrug transporter regulation and structure-function analyses of asymmetric ABC transporters. In this review, we cover the highlights of two decades of research on Cdr1p that has provided a platform to study its structure-function relationships and regulatory circuitry for a better understanding of MDR not only in yeast but also in other organisms.
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“Both the constitutive and transient expression of CDR1 and CDR2 genes seem to be regulated via interactions at multiple cis-acting elements within the CDR1 and CDR2 promoters.91”
From Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus Candida albicans (2020) · cites this paper as [91]
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Metadata
- Authors
- Prasad, R., Banerjee, A., Khandelwal, N. K., & Dhamgaye, S.
- Affiliations
- Jawaharlal Nehru University (IN)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2015-12
- Volume
- 14
- Issue
- 12
- Pages
- 1154-1164
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC4664872
- OpenAlex
- W2189610494
- Cited by
- 123
- References
- 75
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 20 · 2018: 8 · 2017: 10 · 2016: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida albicans, Cdr1p, multidrug resistance, ABC transporters, antifungal resistance, membrane transporters, structure-function relationship, transporter regulation, major facilitator superfamily, fungal pathogens
- MeSH terms
- Amino Acid Sequence, Candida albicans, Fungal Proteins, Molecular Sequence Data, Xenobiotics, Gene Expression Regulation, Fungal, Protein Structure, Tertiary, Membrane Transport Proteins
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