Cited by 123Drug Transport and Resistance MechanismsAntifungal resistance and susceptibilityFungal and yeast genetics research

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The ABCs of Candida albicans Multidrug Transporter Cdr1

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Prasad, Rajendra, Banerjee, Atanu, Khandelwal, Nitesh Kumar, Dhamgaye, Sanjiveeni·2015·Eukaryotic Cell

DOI 10.1128/ec.00137-15PMC PMC4664872

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Abstract

In the light of multidrug resistance (MDR) among pathogenic microbes and cancer cells, membrane transporters have gained profound clinical significance. Chemotherapeutic failure, by far, has been attributed mainly to the robust and diverse array of these proteins, which are omnipresent in every stratum of the living world. Candida albicans, one of the major fungal pathogens affecting immunocompromised patients, also develops MDR during the course of chemotherapy. The pivotal membrane transporters that C. albicans has exploited as one of the strategies to develop MDR belongs to either the ATP binding cassette (ABC) or the major facilitator superfamily (MFS) class of proteins. The ABC transporter Candida drug resistance 1 protein (Cdr1p) is a major player among these transporters that enables the pathogen to outplay the battery of antifungals encountered by it. The promiscuous Cdr1 protein fulfills the quintessential need of a model to study molecular mechanisms of multidrug transporter regulation and structure-function analyses of asymmetric ABC transporters. In this review, we cover the highlights of two decades of research on Cdr1p that has provided a platform to study its structure-function relationships and regulatory circuitry for a better understanding of MDR not only in yeast but also in other organisms.

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See all 123

Authors: Prasad, R., Banerjee, A., Khandelwal, N. K., & Dhamgaye, S.
Affiliations: Jawaharlal Nehru University (IN)
ORCID: Prasad, Rajendra
Banerjee, Atanu
Khandelwal, Nitesh Kumar
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2015-12
Volume: 14
Issue: 12
Pages: 1154-1164
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.00137-15
PMC: PMC4664872
OpenAlex: W2189610494
Cited by: 123
References: 75
Citations by year: 2026: 7 · 2025: 18 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 20 · 2018: 8 · 2017: 10 · 2016: 4
FWCI: 0.79
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida albicans, Cdr1p, multidrug resistance, ABC transporters, antifungal resistance, membrane transporters, structure-function relationship, transporter regulation, major facilitator superfamily, fungal pathogens
MeSH terms: Amino Acid Sequence, Candida albicans, Fungal Proteins, Molecular Sequence Data, Xenobiotics, Gene Expression Regulation, Fungal, Protein Structure, Tertiary, Membrane Transport Proteins

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The ABCs of Candida albicans Multidrug Transporter Cdr1

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