The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport
Open accessAbstract
The nuclear envelope is a physical barrier between the nucleus and cytoplasm and, as such, separates the mechanisms of transcription from translation. This compartmentalization of eukaryotic cells allows spatial regulation of gene expression; however, it also necessitates a mechanism for transport between the nucleus and cytoplasm. Macromolecular trafficking of protein and RNA occurs exclusively through nuclear pore complexes (NPCs), specialized channels spanning the nuclear envelope. A novel family of NPC proteins, the FG-nucleoporins (FG-Nups), coordinates and potentially regulates NPC translocation. The extensive repeats of phenylalanine-glycine (FG) in each FG-Nup directly bind to shuttling transport receptors moving through the NPC. In addition, FG-Nups are essential components of the nuclear permeability barrier. In this review, we discuss the structural features, cellular functions, and evolutionary conservation of the FG-Nups.
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Cites
The interplay between structure and function in intrinsically unstructured proteins
Tompa, P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.072 · Cited by 717
Fagotto, F., Glück, U., & Gumbiner, B. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70082-x · Cited by 434
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Metadata
- Authors
- Terry, L. J., & Wente, S. R.
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2009-12
- Volume
- 8
- Issue
- 12
- Pages
- 1814-1827
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- OpenAlex
- W2159923856
- Cited by
- 237
- References
- 2
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Terry, L. J., & Wente, S. R. (2009). Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport. Eukaryotic Cell. https://doi.org/10.1128/ec.00225-09
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