The Aspergillus fumigatus P-Type Golgi Apparatus Ca 2+ /Mn 2+ ATPase PmrA Is Involved in Cation Homeostasis and Cell Wall Integrity but Is Not Essential for Pathogenesis

Pinchai, Nadthanan; Juvvadi, Praveen Rao; Fortwendel, Jarrod R.; Perfect, B. Zachary; Rogg, Luise E.; Asfaw, Yohannes G.; Steinbach, William J.

doi:10.1128/ec.00378-09

The Aspergillus fumigatus P-Type Golgi Apparatus Ca 2+ /Mn 2+ ATPase PmrA Is Involved in Cation Homeostasis and Cell Wall Integrity but Is Not Essential for Pathogenesis

The Aspergillus fumigatus Δ pmrA (Golgi apparatus Ca 2+ /Mn 2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to c…