The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
The medial-Golgi Ion Pump Pmr1 Supplies the Yeast Secretory Pathway with Ca2+and Mn2+Required for Glycosylation, Sorting, and Endoplasmic Reticulum-Associated Protein Degradation
Open accessAbstract
The yeast Ca 2+adenosine triphosphatase Pmr1, located in medial-Golgi, has been implicated in intracellular transport of Ca 2+and Mn 2+ions. We show here that addition of Mn 2+greatly alleviates defects ofpmr1 mutants in N-linked and O-linked protein glycosylation. In contrast, accurate sorting of carboxypeptidase Y (CpY) to the vacuole requires a sufficient supply of intralumenal Ca 2+. Most remarkably, pmr1 mutants are also unable to degrade CpY*, a misfolded soluble endoplasmic reticulum protein, and display phenotypes similar to mutants defective in the stress response to malfolded endoplasmic reticulum proteins. Growth inhibition of pmr1 mutants on Ca 2+-deficient media is overcome by expression of other Ca 2+pumps, including a SERCA-type Ca 2+adenosine triphosphatase from rabbit, or by Vps10, a sorting receptor guiding non-native luminal proteins to the vacuole. Our analysis corroborates the dual function of Pmr1 in Ca 2+and Mn 2+transport and establishes a novel role of this secretory pathway pump in endoplasmic reticulum-associated processes.
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Andresen, E., Peiter, E., & Küpper, H. (2018) · Journal of Experimental Botany · doi:10.1093/jxb/erx465 · Cited by 431
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Metadata
- Authors
- Dürr, G., Strayle, J., Plemper, R., Elbs, S., Klee, S. K., Catty, P., Wolf, D. H., & Rudolph, H. K.
- Venue
- Molecular Biology of the Cell
- Published
- 1998-05
- Volume
- 9
- Issue
- 5
- Pages
- 1149-1162
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2110949951
- Cited by
- 388
- References
- 70
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The medial-Golgi Ion Pump Pmr1 Supplies the Yeast Secretory Pathway with Ca2+and Mn2+Required for Glycosylation, Sorting, and Endoplasmic Reticulum-Associated Protein Degradation. https://app.cochat.ai/papers/10.1091/mbc.9.5.1149
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- Dürr, G., Strayle, J., Plemper, R., Elbs, S., Klee, S. K., Catty, P., Wolf, D. H., & Rudolph, H. K. (1998). The medial-Golgi Ion Pump Pmr1 Supplies the Yeast Secretory Pathway with Ca2+and Mn2+Required for Glycosylation, Sorting, and Endoplasmic Reticulum-Associated Protein Degradation. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.9.5.1149
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