Memory CD4 T cells enhance primary CD8 T-cell responses
Open accessAbstract
CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisiting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.
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Tfh cells are important for generating memory B cells, plasma cells, and antibodies, while Th1 cells help improve memory CD8+ T cell responses.
“CD4+ T follicular helper (Tfh) cells have key roles in the development of memory B cells, plasma cells, and antibodies, whereas Th1 cells support and enhance the quality of memory CD8+ T cell responses (Crotty, 2011; Krawczyk et al., 2007; Luckheeram et al., 2012; Williams et al., 2006).”
From Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination (2021) · cites this paper as Krawczyk et al., 2007
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- Authors
- Krawczyk, C. M., Shen, H., & Pearce, E. J.
- Affiliations
- University of Pennsylvania (US)
- Department of Pathobiology, School of Veterinary Medicine
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2007-07
- Volume
- 75
- Issue
- 7
- Pages
- 3556-3560
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC1932926
- OpenAlex
- W2113329403
- Cited by
- 48
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 45025, R01AI045025, R01AI053825, AI53825)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- memory CD4+ T cells, CD8+ T cell responses, Th1 cells, Th2 cells, T cell help, cytokine production, pathogenic bacteria, viral pathogens, vaccination, immunotherapy
- MeSH terms
- Animals, Dendritic Cells, Immunization, Immunologic Memory, Listeriosis, Listeria monocytogenes, Lymphocyte Activation, Mice, Inbred C57BL, Ovalbumin, Propionibacterium acnes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Th1 Cells, Mice
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