Cited by 75Bacterial Genetics and BiotechnologyAntibiotic Resistance in BacteriaRedox biology and oxidative stress

Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide

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Juttukonda, Lillian J., Green, Erin R., Lonergan, Zachery R., Heffern, Marie C., Chang, Christopher J., Skaar, Eric P.·2019·Infection and Immunity

Abstract

Acinetobacter baumannii is a Gram-negative opportunistic pathogen that causes diverse infections, including pneumonia, bacteremia, and wound infections. Due to multiple intrinsic and acquired antimicrobial-resistance mechanisms,A. baumannii isolates are commonly multidrug resistant, and infections are notoriously difficult to treat.

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Crossref · 10.1128/iai.00413-18

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  • ROS response is under the control of master regulators and transcription factors such as OxyR, PerR, OhrR, and SoxRS, which can be stimulated by direct oxidation of their sensor proteins and then regulate the bacterial comeback appropriately.

    “can be stimulated by direct oxidation of their sensor proteins and then regulating the bacterial comeback appropriately [192].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [191]

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Authors
Juttukonda, L. J., Green, E. R., Lonergan, Z. R., Heffern, M. C., Chang, C. J., & Skaar, E. P.
Affiliations
  • Vanderbilt University (US)
  • University of California, Berkeley (US)
  • Howard Hughes Medical Institute (US)
Venue
Infection and Immunity
Published
2019-01
Volume
87
Issue
1
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
OpenAlex
W2896753225
Cited by
75
References
78
Citations by year
2026: 10 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 9 · 2020: 12 · 2019: 6
FWCI
4.14
Type
journal article
Language
en
Open access
Locations
  • Infection and Immunity (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • HHS | NIH | National Institute of Allergy and Infectious Diseases (AI101171, AI069233, AI073843, F31 AI136255)
  • HHS | NIH | National Institute of General Medical Sciences (T32 GM07347, GM79465)
  • Howard Hughes Medical Institute
  • American Heart Association (15PRE25060007)
  • HHS | NIH | National Institute of Environmental Health Sciences (T32 ES007028)
  • HHS | NIH | National Heart, Lung, and Blood Institute (T32HL094296)
  • DOD | Defense Advanced Research Projects Agency
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
Acinetobacter baumannii, OxyR, hydrogen peroxide, oxidative stress response, transcriptional regulation, multidrug resistance, opportunistic pathogens, antimicrobial resistance
MeSH terms
Acinetobacter Infections, Animals, Anti-Infective Agents, Local, Hydrogen Peroxide, Repressor Proteins, Stress, Physiological, Gene Expression Regulation, Bacterial, Oxidants, Acinetobacter baumannii, Mice

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