Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide
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Acinetobacter baumannii is a Gram-negative opportunistic pathogen that causes diverse infections, including pneumonia, bacteremia, and wound infections. Due to multiple intrinsic and acquired antimicrobial-resistance mechanisms,A. baumannii isolates are commonly multidrug resistant, and infections are notoriously difficult to treat.
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ROS response is under the control of master regulators and transcription factors such as OxyR, PerR, OhrR, and SoxRS, which can be stimulated by direct oxidation of their sensor proteins and then regulate the bacterial comeback appropriately.
“can be stimulated by direct oxidation of their sensor proteins and then regulating the bacterial comeback appropriately [192].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [191]
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The Molecular Basis of Acinetobacter baumannii Cadmium Toxicity and Resistance
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CsrA-Controlled Proteins Reveal New Dimensions of Acinetobacter baumannii Desiccation Tolerance
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DksA is a conserved master regulator of stress response in Acinetobacter baumannii
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Diclofenac sensitizes multi-drug resistant Acinetobacter baumannii to colistin
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Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii
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Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis
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Physiological roles of an Acinetobacter -specific σ factor
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DksA is a central regulatory switch for stress protection and virulence in Acinetobacter baumanniiPreprint
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Imaging Infection Across Scales of Size: From Whole Animals to Single Molecules
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The Overlooked Role of Biocides in Driving Antibiotic Resistance in Acinetobacter baumannii
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A minimalist opportunist: the emergence of Acinetobacter baumannii
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- Authors
- Juttukonda, L. J., Green, E. R., Lonergan, Z. R., Heffern, M. C., Chang, C. J., & Skaar, E. P.
- Affiliations
- Vanderbilt University (US)
- University of California, Berkeley (US)
- Howard Hughes Medical Institute (US)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2019-01
- Volume
- 87
- Issue
- 1
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC6300632
- OpenAlex
- W2896753225
- Cited by
- 75
- References
- 78
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 9 · 2020: 12 · 2019: 6
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (AI101171, AI069233, AI073843, F31 AI136255)
- HHS | NIH | National Institute of General Medical Sciences (T32 GM07347, GM79465)
- Howard Hughes Medical Institute
- American Heart Association (15PRE25060007)
- HHS | NIH | National Institute of Environmental Health Sciences (T32 ES007028)
- HHS | NIH | National Heart, Lung, and Blood Institute (T32HL094296)
- DOD | Defense Advanced Research Projects Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Acinetobacter baumannii, OxyR, hydrogen peroxide, oxidative stress response, transcriptional regulation, multidrug resistance, opportunistic pathogens, antimicrobial resistance
- MeSH terms
- Acinetobacter Infections, Animals, Anti-Infective Agents, Local, Hydrogen Peroxide, Repressor Proteins, Stress, Physiological, Gene Expression Regulation, Bacterial, Oxidants, Acinetobacter baumannii, Mice
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