Cited by 305Clostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders

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Suppression of Clostridium difficile in the Gastrointestinal Tracts of Germfree Mice Inoculated with a Murine Isolate from the Family Lachnospiraceae

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Reeves, Angela E., Koenigsknecht, Mark J., Bergin, Ingrid L., Young, Vincent B.·2012·Infection and Immunity

DOI 10.1128/iai.00647-12PMC PMC3486043

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Abstract

The indigenous microbial community of the gastrointestinal (GI) tract determines susceptibility to Clostridium difficile colonization and disease. Previous studies have demonstrated that antibiotic-treated mice challenged with C. difficile either developed rapidly lethal C. difficile infection or were stably colonized with mild disease. The GI microbial community of animals with mild disease was dominated by members of the bacterial family Lachnospiraceae, while the gut community in moribund animals had a predominance of Escherichia coli. We investigated the roles of murine Lachnospiraceae and E. coli strains in colonization resistance against C. difficile in germfree mice. Murine Lachnospiraceae and E. coli isolates were cultured from wild-type mice. The ability of each of these isolates to interfere with C. difficile colonization was tested by precolonizing germfree mice with these bacteria 4 days prior to experimental C. difficile challenge. Mice precolonized with a murine Lachnospiraceae isolate, but not those colonized with E. coli, had significantly decreased C. difficile colonization, lower intestinal cytotoxin levels and exhibited less severe clinical signs and colonic histopathology. Infection of germfree mice or mice precolonized with E. coli with C. difficile strain VPI 10463 was uniformly fatal by 48 h, but only 20% mortality was seen at 2 days in mice precolonized with the Lachnospiraceae isolate prior to challenge with VPI 10463. These findings confirm that a single component of the GI microbiota, a murine Lachnospiraceae isolate, could partially restore colonization resistance against C. difficile. Further study of the members within the Lachnospiraceae family could lead to a better understanding of mechanisms of colonization resistance against C. difficile and novel therapeutic approaches for the treatment and prevention of C. difficile infection.

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Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
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Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739
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Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179
The Phylogeny of the Genus Clostridium: Proposal of Five New Genera and Eleven New Species Combinations
Collins, M. D., Lawson, P. A., Willems, A., Córdoba, J. J., Fernández‐Garayzábal, J. F., GARCIA, P., Cai, J., Hippe, H., & Farrow, J. A. E. (1994) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-44-4-812 · Cited by 1,690
The microbiology of butyrate formation in the human colon
Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11467.x · Cited by 1,320
Phylogenetic Relationships of Butyrate-Producing Bacteria from the Human Gut
Barcenilla, A., Pryde, S. E., Martin, J. C., Duncan, S. H., Stewart, C. S., Henderson, C., & Flint, H. J. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.4.1654-1661.2000 · Cited by 996
Colonization resistance of the digestive tract in conventional and antibiotic-treated mice
van der Waaij, D., Vries, J. M. B.-D., & der Wees, J. E. C. L.-V. (1971) · Journal of Hygiene · doi:10.1017/s0022172400021653 · Cited by 907
INTESTINAL FLORA IN NEW-BORN INFANTS
Hall, I. C. (1935) · American journal of diseases of children · doi:10.1001/archpedi.1935.01970020105010 · Cited by 766

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Faculty Opinions recommendation of Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation.
Wingard, J. R., & Farhadfar, N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736117892.793563392
Faculty Opinions recommendation of Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.
Borenstein, E., & Muller, E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732223689.793566912
Simplified fecal community transplant restores Clostridioides difficile colonization resistance to antibiotic perturbed murine communitiesPreprint
Lesniak, N. A., Tomkovich, S., Henry, A., Taylor, A., Colovas, J., Bishop, L., McBride, K., & Schloss, P. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.11.491589
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Penney, J. A., Wick, J., Basein, T., & Doron, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-98427-4_16
Making yourself at home in the intestinal tract - Dynamics of the microbiome, resistome and host-pathogen interactions Inwendig vertrouwd voelen - De dynamiek van de darmmicrobiota, het resistoom en van gastheer-pathogene interacties
Stege, P. B. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1530
Additional file 12 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643076
Additional file 9 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643118
Additional file 11 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S.-S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643073
Additional file 7 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643112
Additional file 16 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643088
Additional file 14 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643082
Additional file 6 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643109
Additional file 4 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643103
Additional file 5 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643106
Additional file 8 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643115
Additional file 13 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643079
Additional file 3 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643100
Additional file 10 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643070
Additional file 15 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M., Abuduaini, R., Yu, H., Li, D., Wang, Y., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643085
Clostridioides difficile infection
Crawford, C. V., & Dawod, E. (2024) · doi:10.1093/med/9780192863584.003.0025
In vitro and in Vivo Models for Understanding Clostridioides difficile
Auchtung, J. M. (2025) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2025.07.009
Additional file 18 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M.-X., Abuduaini, R., Yu, H.-Y., Li, D.-H., Wang, Y.-J., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S.-S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643094
Additional file 2 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M.-X., Abuduaini, R., Yu, H.-Y., Li, D.-H., Wang, Y.-J., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S.-S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643097
Additional file 17 of Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank
Liu, C., Du, M.-X., Abuduaini, R., Yu, H.-Y., Li, D.-H., Wang, Y.-J., Zhou, N., Jiang, M.-Z., Niu, P.-X., Han, S.-S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14643091
Lactiplantibacillus plantarum ELPL14 and ELPL23 combat Listeria monocytogenes infection by fortifying gut barrier, reprogramming immunity and restoring microbial homeostasis in mice
Huang, X., He, Y., Xie, K., Wei, H., & Tao, X. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108165
Impact des phages tempérés sur la stabilité du microbiote intestinal : la lysogénie n'est pas un long fleuve tranquille
Cornuault, J. K. (2018) · theses.fr (ABES) · doi:10.70675/55d00c01zb915z43d1z8f0bzeead74fa3383
Rôle du microbiote dans les interactions hôte-pathogène dans la tuberculose
Dumas, A. (2018) · theses.fr (ABES) · doi:10.70675/6773a408zdb52z44bbzb51ez3998deaf3ded

Authors: Reeves, A. E., Koenigsknecht, M. J., Bergin, I. L., & Young, V. B.
Affiliations: University of Michigan (US)
ORCID: Koenigsknecht, Mark J.
Bergin, Ingrid L.
Young, Vincent B.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2012-11
Volume: 80
Issue: 11
Pages: 3786-3794
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00647-12
PMC: PMC3486043
OpenAlex: W2122459017
Cited by: 292
References: 47
Citations by year: 2026: 7 · 2025: 14 · 2024: 14 · 2023: 13 · 2022: 25 · 2021: 32 · 2020: 25 · 2019: 23 · 2018: 28 · 2017: 21 · 2016: 23 · 2015: 26 · 2014: 23 · 2013: 18
FWCI: 14.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (U19AI090871, AI090871)
National Institute of Diabetes and Digestive and Kidney Diseases (DK089503, R01DK070875, P30DK089503)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Clostridium difficile, colonization resistance, Lachnospiraceae, gut microbiota, germ-free mice, Escherichia coli, Clostridium difficile infection, colonic histopathology, antibiotic-treated mice
MeSH terms: Animals, Escherichia coli, Germ-Free Life, Mice, Inbred C57BL, Phylogeny, RNA, Ribosomal, 16S, Colony Count, Microbial, Clostridioides difficile, Gram-Positive Endospore-Forming Rods, Gastrointestinal Tract, Mice, Metagenome

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Suppression of Clostridium difficile in the Gastrointestinal Tracts of Germfree Mice Inoculated with a Murine Isolate from the Family Lachnospiraceae

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