The microbiology of butyrate formation in the human colon
Abstract
Butyrate arising from microbial fermentation is important for the energy metabolism and normal development of colonic epithelial cells and has a mainly protective role in relation to colonic disease. While certain dietary substrates such as resistant starch appear to be butyrogenic in the colon, it is not known to what extent these stimulate butyrate production directly, e.g. by promoting amylolytic species, or indirectly, e.g. through cross-feeding of fermentation products. Cultural and molecular studies indicate that the most numerous butyrate-producing bacteria found in human faeces are highly oxygen-sensitive anaerobes belonging to the Clostridial clusters IV and XIVa. These include many previously undescribed species related to Eubacterium, Roseburia, Faecalibacterium and Coprococcus whose distribution and metabolic characteristics are under investigation. A better understanding of the microbial ecology of colonic butyrate-producing bacteria will help to explain the influence of diet upon butyrate supply, and to suggest new approaches for optimising microbial activity in the large intestine.
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Butyrate-producing genera Roseburia and Faecalibacterium were increased in adolescent functional constipation according to 16S rRNA sequencing studies.
“Butyrate-producing genera, Roseburia and Faecalibacterium , were increased in adolescent FC according to 16S rRNA sequencing studies [ 27 , 62 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [62]
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- Authors
- Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Flint, Harry J
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12
- Volume
- 217
- Issue
- 2
- Pages
- 133-139
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2147726663
- Cited by
- 1,320
- References
- 47
- Citations by year
- 2026: 25 · 2025: 49 · 2024: 54 · 2023: 64 · 2022: 93 · 2021: 117 · 2020: 114 · 2019: 99 · 2018: 90 · 2017: 79 · 2016: 79 · 2015: 74 · 2014: 42 · 2013: 59 · 2012: 52
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- butyrate production, human colon, colonic fermentation, Clostridium cluster IV, Clostridium cluster XIVa, Faecalibacterium, Roseburia, Eubacterium, Coprococcus, resistant starch, dietary substrates, diet and gut microbiota, microbial ecology
- MeSH terms
- Anaerobiosis, Bacteria, Anaerobic, Butyrates, Colon, Culture Media, Feces, Fermentation, Humans, Models, Biological, Phylogeny
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