The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal Microbiota
Open accessAbstract
Transmission is an essential stage of a pathogen's life cycle and remains poorly understood. We describe here a model in which persistently infected 129X1/SvJ mice provide a natural model of Salmonella enterica serovar Typhimurium transmission. In this model only a subset of the infected mice, termed supershedders, shed high levels (>10 8 CFU/g) of Salmonella serovar Typhimurium in their feces and, as a result, rapidly transmit infection. While most Salmonella serovar Typhimurium-infected mice show signs of intestinal inflammation, only supershedder mice develop colitis. Development of the supershedder phenotype depends on the virulence determinants Salmonella pathogenicity islands 1 and 2, and it is characterized by mucosal invasion and, importantly, high luminal abundance of Salmonella serovar Typhimurium within the colon. Immunosuppression of infected mice does not induce the supershedder phenotype, demonstrating that the immune response is not the main determinant of Salmonella serovar Typhimurium levels within the colon. In contrast, treatment of mice with antibiotics that alter the health-associated indigenous intestinal microbiota rapidly induces the supershedder phenotype in infected mice and predisposes uninfected mice to the supershedder phenotype for several days. These results demonstrate that the intestinal microbiota plays a critical role in controlling Salmonella serovar Typhimurium infection, disease, and transmissibility. This novel model should facilitate the study of host, pathogen, and intestinal microbiota factors that contribute to infectious disease transmission.
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Cites
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Interactions between the microbiota and pathogenic bacteria in the gut
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Gut inflammation provides a respiratory electron acceptor for Salmonella
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Metadata
- Authors
- Lawley, T. D., Bouley, D. M., Hoy, Y. E., Gerke, C., Relman, D. A., & Monack, D. M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2008-01
- Volume
- 76
- Issue
- 1
- Pages
- 403-416
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2170512706
- Cited by
- 307
- References
- 9
- FWCI
- 16.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Lawley, T. D., Bouley, D. M., Hoy, Y. E., Gerke, C., Relman, D. A., & Monack, D. M. (2008). Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal Microbiota. Infection and Immunity. https://doi.org/10.1128/iai.01189-07
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