How flagellin and toll-like receptor 5 contribute to enteric infection

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Plants have a sensitive perception system for the most conserved domain of bacterial flagellin

Felix, G., Duran, J. D., Volko, S. M., & Boller, T. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00265.x · Cited by 1,719 · see citing works

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131 · see citing works

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works

Pretreatment of Mice with Streptomycin Provides a <i>Salmonella enterica</i> Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

Barthel, M., Hapfelmeier, S., Quintanilla-Martínez, L., Kremer, M., Rohde, M., Hogardt, M., Pfeffer, K., Rüssmann, H., & Hardt, W.-D. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2839-2858.2003 · Cited by 1,020 · see citing works

Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

Smith, K. D., Andersen‐Nissen, E., Hayashi, F., Strobe, K. L., Bergman, M. A., Barrett, S. L. R., Cookson, B. T., & Aderem, A. A. (2003) · Nature Immunology · doi:10.1038/ni1011 · Cited by 808 · see citing works

Evasion of Toll-like receptor 5 by flagellated bacteria

Andersen‐Nissen, E., Smith, K. D., Strobe, K. L., Barrett, S. L. R., Cookson, B. T., Logan, S. M., & Aderem, A. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502040102 · Cited by 657 · see citing works

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

Ren, T., Zamboni, D. S., Roy, C. R., Dietrich, W. F., & Vance, R. E. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020018 · Cited by 536 · see citing works

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

Molofsky, A. B., Byrne, B. G., Whitfield, N. N., Madigan, C. A., Fuse, E. T., Tateda, K., & Swanson, M. S. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051659 · Cited by 490 · see citing works

Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling

Samatey, F. A., Imada, K., Nagashima, S., Vonderviszt, F., Kumasaka, T., Yamamoto, M., & Namba, K. (2001) · Nature · doi:10.1038/35066504 · Cited by 482 · see citing works

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

Uematsu, S., Jang, M. H., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., et al. (2006) · Nature Immunology · doi:10.1038/ni1362 · Cited by 450 · see citing works

Toll-like Receptor (TLR) 2 and TLR5, but Not TLR4, Are Required for Helicobacter pylori-induced NF-κB Activation and Chemokine Expression by Epithelial Cells

Smith, M. F., Mitchell, A., Li, G., Ding, S., Fitzmaurice, A. M., Ryan, K., Crowe, S. E., & Goldberg, J. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305536200 · Cited by 423 · see citing works

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

Gewirtz, A. T., Simon, P. O., Schmitt, C. K., Taylor, L. J., Hagedorn, C. H., O’Brien, A. D., Neish, A. S., & Madara, J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10501 · Cited by 394 · see citing works

The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms

Hapfelmeier, S., Stecher, B., Barthel, M., Kremer, M., Müller, A. J., Heikenwälder, M. F., Stallmach, T., Hensel, M., Pfeffer, K., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1675 · Cited by 394 · see citing works

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

Crellin, N. K., García, R., Hadisfar, O., Allan, S., Steiner, T. S., & Levings, M. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8051 · Cited by 375 · see citing works

Flagella and Chemotaxis Are Required for Efficient Induction ofSalmonella entericaSerovar Typhimurium Colitis in Streptomycin-Pretreated Mice

Stecher, B., Hapfelmeier, S., Müller, C., Kremer, M., Stallmach, T., & Hardt, W. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4138-4150.2004 · Cited by 339 · see citing works

Helicobacter pylori Flagellin Evades Toll‐Like Receptor 5–Mediated Innate Immunity

Gewirtz, A. T., Yu, Y., Krishna, U. S., Israel, D. A., Lyons, S., & Peek, R. M. (2004) · The Journal of Infectious Diseases · doi:10.1086/386289 · Cited by 295 · see citing works

Enteroaggregative Escherichia coli Produce Intestinal Inflammation and Growth Impairment and Cause Interleukin‐8 Release from Intestinal Epithelial Cells

Steiner, T. S., Lima, A. Â. M., Nataro, J. P., & Guerrant, R. L. (1998) · The Journal of Infectious Diseases · doi:10.1086/513809 · Cited by 288 · see citing works

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila

Diez, E., Lee, S. H., Gauthier, S., Yaraghi, Z., Tremblay, M. L., Vidal, S. M., & Gros, P. (2002) · Nature Genetics · doi:10.1038/ng1065 · Cited by 282 · see citing works

Flagellin, a Novel Mediator of Salmonella -Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction

Eaves-Pyles, T. D., Murthy, K. G. K., Liaudet, L., Virág, L., Ross, G. F., Soriano, F. G., Szabó, C., & Salzman, A. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1248 · Cited by 270 · see citing works

Changes in flagellin glycosylation affect <i>Campylobacter</i> autoagglutination and virulence

Guerry, P., Ewing, C. P., Schirm, M., Lorenzo, M., Kelly, J., Pattarini, D., Majam, G., Thibault, P., & Logan, S. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05100.x · Cited by 265 · see citing works

Naip5 Affects Host Susceptibility to the Intracellular Pathogen Legionella pneumophila

Wright, E. K., Goodart, S. A., Growney, J. D., Hadinoto, V., Endrizzi, M. G., Long, E. M., Sadigh, K., Abney, A. L., Bernstein-Hanley, I., & Dietrich, W. F. (2003) · Current Biology · doi:10.1016/s0960-9822(02)01359-3 · Cited by 260 · see citing works

Pseudomonas aeruginosa Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5

Adamo, R., Sokol, S., Soong, G., Gómez, M. I., & Prince, A. S. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0260oc · Cited by 258 · see citing works

Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells

Steiner, T. S., Nataro, J. P., Poteet-Smith, C. E., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8892 · Cited by 249 · see citing works

Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence ofSalmonella entericaSerovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis

Schmitt, C. K., Ikeda, J. S., Darnell, S. C., Watson, P. R., Bispham, J., Wallis, T. S., Weinstein, D. L., Metcalf, E. S., & O’Brien, A. D. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5619-5625.2001 · Cited by 239 · see citing works

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation

Rhee, S. H., Im, E., Riegler, M., Kokkotou, E., O'Brien, M., & Pothoulakis, C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502174102 · Cited by 229 · see citing works

A Bacterial Flagellin, Vibrio vulnificus FlaB, Has a Strong Mucosal Adjuvant Activity To Induce Protective Immunity

Lee, S. E., Kim, S. Y., Jeong, B. C., Kim, Y. R., Bae, S. J., Ahn, O. S., Lee, J., Song, H.-C., Kim, J. M., Choy, H. E., et al. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.694-702.2006 · Cited by 226 · see citing works

Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells

Tallant, T. C., Deb, A., Kar, N. S., Lupica, J. A., de Veer, M. J., & DiDonato, J. A. (2004) · BMC Microbiology · doi:10.1186/1471-2180-4-33 · Cited by 212 · see citing works

Induction of Macrophage Nitric Oxide Production by Gram-Negative Flagellin Involves Signaling Via Heteromeric Toll-Like Receptor 5/Toll-Like Receptor 4 Complexes

Mizel, S. B., Honko, A. N., Moors, M. A., Smith, P. S., & West, A. P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.6217 · Cited by 204 · see citing works

Salmonella entericaSerovar Typhimurium Pathogenicity Island 2 Is Necessary for Complete Virulence in a Mouse Model of Infectious Enterocolitis

Coburn, B. A., Li, Y., Owen, D., Vallance, B. A., & Finlay, B. B. (2005) · Infection and Immunity · doi:10.1128/iai.73.6.3219-3227.2005 · Cited by 204 · see citing works

In Vitro and ex Vivo Activation of the TLR5 Signaling Pathway in Intestinal Epithelial Cells by a Commensal Escherichia coli Strain

Bambou, J., Giraud, A., Ménard, S., Bègue, B., Rakotobé, S., Heyman, M., Taddéi, F., Cerf–Bensussan, N., & Gaboriau‐Routhiau, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405410200 · Cited by 195 · see citing works

Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5

Lee, S. K., Stack, A., Katzowitsch, E., Aizawa, S. I., Suerbaum, S., & Josenhans, C. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.018 · Cited by 188 · see citing works

Analysis of the Contribution of Salmonella Pathogenicity Islands 1 and 2 to Enteric Disease Progression Using a Novel Bovine Ileal Loop Model and a Murine Model of Infectious Enterocolitis

Coombes, B. K., Coburn, B. A., Potter, A. A., Gomis, S. M., Mirakhur, K. K., Li, Y., & Finlay, B. B. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7161-7169.2005 · Cited by 168 · see citing works

High-Affinity Interaction between Gram-Negative Flagellin and a Cell Surface Polypeptide Results in Human Monocyte Activation

McDermott, P. F., Ciacci-Woolwine, F., Snipes, J. A., & Mizel, S. B. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5525-5529.2000 · Cited by 161 · see citing works

SalmonellaFlagellin Induces Tumor Necrosis Factor Alpha in a Human Promonocytic Cell Line

Ciacci-Woolwine, F., Blomfield, I. C., Richardson, S. H., & Mizel, S. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1127-1134.1998 · Cited by 154 · see citing works

Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative Flagellin

Mizel, S. B., West, A. P., & Hantgan, R. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303481200 · Cited by 153 · see citing works

Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-κB and MAP kinase pathways and the upregulated expression of interleukin 8

Berin, M. C., Darfeuille–Michaud, A., Egan, L. J., et al. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00218.x · Cited by 146 · see citing works

Two Nonadjacent Regions in Enteroaggregative Escherichia coli Flagellin Are Required for Activation of Toll-like Receptor 5

Donnelly, M. A., & Steiner, T. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206851200 · Cited by 144 · see citing works

Salmonella Flagellin-Dependent Proinflammatory Responses Are Localized to the Conserved Amino and Carboxyl Regions of the Protein

Eaves-Pyles, T. D., Wong, H. R., Odoms, K., & Pyles, R. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.7009 · Cited by 141 · see citing works

Flagellin of EnteropathogenicEscherichia coliStimulates Interleukin-8 Production in T84 Cells

Zhou, X., Girón, J. A., Torres, A. G., Crawford, J. A., Negrete, E., Vogel, S. N., & Kaper, J. B. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.2120-2129.2003 · Cited by 137 · see citing works

Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1

Cunningham, A. F., Khan, M., Ball, J., Toellner, K., Serre, K., Mohr, E., & MacLennan, I. C. M. (2004) · European Journal of Immunology · doi:10.1002/eji.200425403 · Cited by 134 · see citing works

Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli

Harrington, S. M., Strauman, M. C., Abe, C. M., & Nataro, J. P. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00588.x · Cited by 133 · see citing works

Identification of Conserved Domains in Salmonella muenchen Flagellin That Are Essential for Its Ability to Activate TLR5 and to Induce an Inflammatory Response in Vitro

Murthy, K. G. K., Deb, A., Goonesekera, S. D., Szabó, C., & Salzman, A. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307759200 · Cited by 128 · see citing works

Salmonella typhiFlagella Are Potent Inducers of Proinflammatory Cytokine Secretion by Human Monocytes

Wyant, T. L., Tanner, M. K., & Sztein, M. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3619-3624.1999 · Cited by 124 · see citing works

Roles of Specific Amino Acids in the N Terminus of Pseudomonas aeruginosa Flagellin and of Flagellin Glycosylation in the Innate Immune Response

Verma, A., Arora, S. K., Kuravi, S., et al. (2005) · Infection and Immunity · doi:10.1128/iai.73.12.8237-8246.2005 · Cited by 105 · see citing works

Flagella help Salmonella typhimurium survive within murine macrophages

Weinstein, D. L., Carsiotis, M., Lissner, C. R., & O’Brien, A. D. (1984) · Infection and Immunity · doi:10.1128/iai.46.3.819-825.1984 · Cited by 97 · see citing works

Helicobacter pyloriInduces Interleukin-8 Secretion by Toll-Like Receptor 2- and Toll-Like Receptor 5-Dependent and -Independent Pathways

Torok, A. M., Bouton, A. H., & Goldberg, J. B. (2005) · Infection and Immunity · doi:10.1128/iai.73.3.1523-1531.2005 · Cited by 88 · see citing works

Human Intestinal Microvascular Endothelial Cells Express Toll-Like Receptor 5: A Binding Partner for Bacterial Flagellin

Maaser, C., Heidemann, J., von Eiff, C., Lügering, A., Spahn, T. W., Binion, D. G., Domschke, W., Lügering, N., & Kucharzik, T. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.5056 · Cited by 85 · see citing works

Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin

Tsujita, T., Ishii, A., Tsukada, H., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.11.003 · Cited by 78 · see citing works

Structural Study of Binding of Flagellin by Toll-Like Receptor 5

Jacchieri, S. G., Torquato, R. S., & Brentani, H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.14.4243-4247.2003 · Cited by 78 · see citing works

Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin

Smith, K. D., & Ozinsky, A. (2002) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59430-4_6 · Cited by 77 · see citing works

Activation, cytokine production, and intracellular survival of bacteria in Salmonella -infected human monocyte-derived macrophages and dendritic cells

Pietilä, T. E., Veckman, V., Kyllönen, P., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204721 · Cited by 64 · see citing works

Salmonella typhimurium Coordinately Regulates FliC Location and Reduces Dendritic Cell Activation and Antigen Presentation to CD4+ T cells

Alaniz, R. C., Cummings, L. A., Bergman, M. A., Rassoulian-Barrett, S. L., & Cookson, B. T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3983 · Cited by 63 · see citing works

Potent Immunoregulatory Effects ofSalmonella typhiFlagella on Antigenic Stimulation of Human Peripheral Blood Mononuclear Cells

Wyant, T. L., Tanner, M. K., & Sztein, M. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.3.1338-1346.1999 · Cited by 63 · see citing works

Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway

Lyons, S., Wang, L., Casanova, J. E., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01500 · Cited by 56 · see citing works

Cooperative Interactions between Flagellin and SopE2 in the Epithelial Interleukin-8 Response toSalmonella entericaSerovar Typhimurium Infection

Huang, F., Werne, A., Li, Q., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5052-5062.2004 · Cited by 55 · see citing works

Flagellin-Independent Regulation of Chemokine Host Defense inCampylobacter jejuni-Infected Intestinal Epithelium

Johanesen, P., & Dwinell, M. B. (2006) · Infection and Immunity · doi:10.1128/iai.01740-05 · Cited by 55 · see citing works

The attenuated phenotype of a Salmonella typhimurium flgM mutant is related to expression of FliC flagellin

Schmitt, C. K., Darnell, S. C., & O’Brien, A. D. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.10.2911-2915.1996 · Cited by 49 · see citing works

Gangliosides Inhibit Flagellin Signaling in the Absence of an Effect on Flagellin Binding to Toll-like Receptor 5

West, A. P., Dancho, B. A., & Mizel, S. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411875200 · Cited by 39 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works

Serum endotoxins and flagellin and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Kong, S. Y., Tran, H. Q., Gewirtz, A. T., McKeown-Eyssen, G., Fedirko, V., Romieu, I., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., et al. (2016) · Cancer Epidemiology, Biomarkers &amp; Prevention · doi:10.1158/1055-9965.epi-15-0798 · Cited by 34 · see citing works

Faculty Opinions recommendation of Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.

DiRita, V. J. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2815960.2480057

Toll-like receptory a jejich úloha v systémové zánětlivé reakci

Perková, I. (2016) · Digitální knihovna Univerzity Pardubice (Univerzity Pardubice)

Cross-talk among Toll-like receptors and their ligands

Palazzo, M. C., Gariboldi, S., Zanobbio, L., Dusio, G. F., Selleri, S., Bedoni, M., Balsari, A., & Rumio, C. (2008) · International Immunology · doi:10.1093/intimm/dxn027 · Cited by 29 · see citing works

The Advance Research of Toll-like Receptors

Li, L. (2011) · Clinical Medical Engineering

gp96 Leads the Way for Toll-like Receptors

Harding, C. V. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.003 · Cited by 12 · see citing works