Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

Barthel, Manja; Hapfelmeier, Siegfried; Quintanilla-Martínez, Leticia; Kremer, Marcus; Rohde, Manfred; Hogardt, Michael; Pfeffer, Klaus; Rüssmann, Holger; Hardt, Wolf-Dietrich

doi:10.1128/iai.71.5.2839-2858.2003

Cited by 1,020Salmonella and Campylobacter epidemiologyEscherichia coli research studiesBacterial Genetics and Biotechnology

Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

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Barthel, Manja, Hapfelmeier, Siegfried, Quintanilla-Martínez, Leticia, Kremer, Marcus, Rohde, Manfred, Hogardt, Michael, Pfeffer, Klaus, Rüssmann, Holger +1 more·2003·Infection and Immunity

DOI 10.1128/iai.71.5.2839-2858.2003PMC PMC153285

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Abstract

Salmonella enterica subspecies 1 serovar Typhimurium is a principal cause of human enterocolitis. For unknown reasons, in mice serovar Typhimurium does not provoke intestinal inflammation but rather targets the gut-associated lymphatic tissues and causes a systemic typhoid-like infection. The lack of a suitable murine model has limited the analysis of the pathogenetic mechanisms of intestinal salmonellosis. We describe here how streptomycin-pretreated mice provide a mouse model for serovar Typhimurium colitis. Serovar Typhimurium colitis in streptomycin-pretreated mice resembles many aspects of the human infection, including epithelial ulceration, edema, induction of intercellular adhesion molecule 1, and massive infiltration of PMN/CD18 + cells. This pathology is strongly dependent on protein translocation via the serovar Typhimurium SPI1 type III secretion system. Using a lymphotoxin β-receptor knockout mouse strain that lacks all lymph nodes and organized gut-associated lymphatic tissues, we demonstrate that Peyer's patches and mesenteric lymph nodes are dispensable for the initiation of murine serovar Typhimurium colitis. Our results demonstrate that streptomycin-pretreated mice offer a unique infection model that allows for the first time to use mutants of both the pathogen and the host to study the molecular mechanisms of enteric salmonellosis.

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Infective gastroenteritis produces a profound depletion of the commensal microbiota, whose production of metabolites such as short chain fatty acids and antibiotics normally inhibits pathogen colonisation, as can be seen from the loss of colonisation resistance after antibiotics.
“Infective gastroenteritis produces a profound depletion of the commensal microbiota,118 whose production of metabolites such as SCFAs and antibiotics normally inhibits pathogen colonisation, as can be seen from the loss of colonisation resistance after antibiotics.119”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [119]

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works
Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
Hoiseth, S. K., & Stocker, B. A. D. (1981) · Nature · doi:10.1038/291238a0 · Cited by 2,088 · see citing works
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression
Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Yang, R.-B., Mark, M., Gray, A., Huang, A., Xie, M.-H., Zhang, M., Goddard, A., Wood, W., Gurney, A., & Godowski, P. (1998) · Nature · doi:10.1038/26239 · Cited by 1,319 · see citing works
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096 · see citing works
Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.
Galán, J. E., & Curtiss, R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6383 · Cited by 990 · see citing works
Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.
Jones, B. D., Ghori, N., & Falkow, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.15 · Cited by 883 · see citing works
The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues
Fütterer, A., Mink, K., Luz, A., Kosco‐Vilbois, M. H., & Pfeffer, K. (1998) · Immunity · doi:10.1016/s1074-7613(00)80588-9 · Cited by 732 · see citing works
Self-citation
SalmonellaInteractions with Host Cells: Type III Secretion at Work
Galán, J. E. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.53 · Cited by 730 · see citing works
Toll-like receptors: key mediators of microbe detection
Underhill, D. M., & Ozinsky, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00304-1 · Cited by 684 · see citing works
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes
Vazquez-Torres, A., Jones-Carson, J., Bäumler, A. J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W. T., & Fang, F. C. (1999) · Nature · doi:10.1038/44593 · Cited by 683 · see citing works
THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE
Carter, P. B., & Collins, F. M. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.5.1189 · Cited by 668 · see citing works
Defensins of vertebrate animals
Lehrer, R. I., & Ganz, T. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00303-x · Cited by 662 · see citing works
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry
Eckmann, L., Kagnoff, M. F., & Fierer, J. (1993) · Infection and Immunity · doi:10.1128/iai.61.11.4569-4574.1993 · Cited by 654 · see citing works
DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
Fu, Y., & Chaplin, D. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.399 · Cited by 615 · see citing works
Collaboration of epithelial cells with organized mucosal lymphoid tissues
Neutra, M. R., Mantis, N. J., & Kraehenbühl, J.-P. (2001) · Nature Immunology · doi:10.1038/ni1101-1004 · Cited by 580 · see citing works
Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium.
Takeuchi, A. (1967) · PubMed · Cited by 533 · see citing works
The anatomical basis of intestinal immunity
Mowat, A. M., & Viney, J. L. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00966.x · Cited by 493 · see citing works
Host adapted serotypes of Salmonella enterica
Uzzau, S., Brown, D., Wallis, T. S., et al. (2000) · Epidemiology and Infection · doi:10.1017/s0950268899004379 · Cited by 479 · see citing works
Salmonella: A Model for Bacterial Pathogenesis
Ohl, M., & Miller, S. I. (2001) · Annual Review of Medicine · doi:10.1146/annurev.med.52.1.259 · Cited by 476 · see citing works
Epithelial M Cells: Differentiation and Function
Kraehenbühl, J.-P., & Neutra, M. R. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.301 · Cited by 475 · see citing works
Animal models of infections: enteritis versus typhoid fever
Santos, R. L., Zhang, S., Tsolis, R. M., Kingsley, R. A., Adams, L. G., & Bäumler, A. J. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01495-2 · Cited by 450 · see citing works
Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.
McCormick, B. A., Colgan, S. P., Delp-Archer, C., Miller, S. I., & Madara, J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.4.895 · Cited by 447 · see citing works
SopB, a protein required for virulence of Salmonella dublin , is an inositol phosphate phosphatase
Norris, F. A., Wilson, M. P., Wallis, T. S., Galyov, E. E., & Majerus, P. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14057 · Cited by 439 · see citing works
Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells
Hobbie, S., Chen, L.-M., Davis, R. J., & Galán, J. E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.11.5550 · Cited by 406 · see citing works
Man the barrier! strategic defences in the intestinal mucosa
Nagler‐Anderson, C. (2001) · Nature reviews. Immunology · doi:10.1038/35095573 · Cited by 369 · see citing works
Salmonella Pathogenicity Island 2
Hensel, M. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01935.x · Cited by 362 · see citing works
How the immune system works to protect the host from infection: A personal view
Janeway, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131202998 · Cited by 356 · see citing works
Effect of Streptomycin on Susceptibility of Intestinal Tract to Experimental Salmonella Infection.
Bohnhoff, M., Drake, B. L., & Miller, C. P. (1954) · Experimental Biology and Medicine · doi:10.3181/00379727-86-21030 · Cited by 354 · see citing works
The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins
Kaniga, K., Bossio, J. C., & Galán, J. E. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00450.x · Cited by 322 · see citing works
Contribution of Salmonella typhimurium Virulence Factors to Diarrheal Disease in Calves
Tsolis, R. M., Adams, L. G., Ficht, T. A., & Bäumler, A. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4879-4885.1999 · Cited by 319 · see citing works
The invasion‐associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell
Collazo, C. M., & Galán, J. E. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3781740.x · Cited by 306 · see citing works
Molecular basis of Salmonella‐induced enteritis
Wallis, T. S., & Galyov, E. E. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01892.x · Cited by 300 · see citing works
Experimental Salmonella typhimurium infection in calves
WRAY, C., & Sojka, W. J. (1978) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)32968-0 · Cited by 291 · see citing works
The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches.
Bäumler, A. J., Tsolis, R. M., & Heffron, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.279 · Cited by 288 · see citing works
A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa
Galyov, E. E., Wood, M. W., Rosqvist, R., et al. (1997) · Molecular Microbiology · doi:10.1111/j.1365-2958.1997.mmi525.x · Cited by 284 · see citing works
Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
Kaniga, K., Tucker, S. C., Trollinger, D. B., et al. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.14.3965-3971.1995 · Cited by 277 · see citing works
TheSalmonella entericaSerotype Typhimurium Effector Proteins SipA, SopA, SopB, SopD, and SopE2 Act in Concert To Induce Diarrhea in Calves
Zhang, S., Santos, R. L., Tsolis, R. M., Stender, S., Hardt, W., Bäumler, A. J., & Adams, L. G. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3843-3855.2002 · Cited by 265 · see citing works
Self-citation
RESISTANCE OF THE MOUSE'S INTESTINAL TRACT TO EXPERIMENTAL SALMONELLA INFECTION
Bohnhoff, M., Miller, C. P., & Martin, W. R. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.120.5.805 · Cited by 246 · see citing works
Diverse virulence traits underlying different clinical outcomes of Salmonella infection
Fierer, J., & Guiney, D. G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12561 · Cited by 245 · see citing works
Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence ofSalmonella entericaSerovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis
Schmitt, C. K., Ikeda, J. S., Darnell, S. C., Watson, P. R., Bispham, J., Wallis, T. S., Weinstein, D. L., Metcalf, E. S., & O’Brien, A. D. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5619-5625.2001 · Cited by 239 · see citing works
SopE, a secreted protein of Salmonelladublin, is translocated into the target eukaryotic cell via a sip‐dependent mechanism and promotes bacterial entry
Wood, M. W., Rosqvist, R., Mullan, P. B., Edwards, M. H., & Galyov, E. E. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.00116.x · Cited by 238 · see citing works
Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells
Clark, M. A., Jepson, M. A., Simmons, N. L., & Hirst, B. H. (1994) · Research in Microbiology · doi:10.1016/0923-2508(94)90031-0 · Cited by 235 · see citing works
Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils.
McCormick, B. A., Hofman, P. M., Kim, J., Carnes, D. K., Miller, S. I., & Madara, J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1599 · Cited by 230 · see citing works
Enhanced Susceptibility to Salmonella Infection in Streptomycin-Treated Mice*
Bohnhoff, M., & Miller, C. P. (1962) · The Journal of Infectious Diseases · doi:10.1093/infdis/111.2.117 · Cited by 228 · see citing works
Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins
Kaniga, K., Trollinger, D. B., & Galán, J. E. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.24.7078-7085.1995 · Cited by 226 · see citing works
Identification of a Putative Salmonella enterica Serotype Typhimurium Host Range Factor with Homology to IpaH and YopM by Signature-Tagged Mutagenesis
Tsolis, R. M., Townsend, S. M., Miao, E. A., Miller, S. I., Ficht, T. A., Adams, L. G., & Bäumler, A. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.12.6385-6393.1999 · Cited by 205 · see citing works
RESISTANCE OF THE MOUSE'S INTESTINAL TRACT TO EXPERIMENTAL SALMONELLA INFECTION
Bohnhoff, M., Miller, C. P., & Martin, W. R. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.120.5.817 · Cited by 196 · see citing works
Non‐invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches
Penheiter, K. L., Mathur, N., Giles, D., Fahlen, T. F., & Jones, B. D. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3741745.x · Cited by 181 · see citing works
A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration
Lee, C. A., Silva, M., Siber, A. M., Kelly, A. J., Galyov, E. E., & McCormick, B. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.12283 · Cited by 179 · see citing works
Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion.
Huang, G. T. ‐., Eckmann, L., Savidge, T., & Kagnoff, M. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118825 · Cited by 178 · see citing works
The rectal biopsy appearances in Salmonella colitis
DAY, D. W., Mandal, B. K., & Morson, B. C. (1978) · Histopathology · doi:10.1111/j.1365-2559.1978.tb01700.x · Cited by 176 · see citing works
Intestinal Colonization and Virulence of Salmonella in Mice
Hohmann, A. W., Schmidt, G., & Rowley, D. (1978) · Infection and Immunity · doi:10.1128/iai.22.3.763-770.1978 · Cited by 165 · see citing works
Macrophage NRAMP1 and its role in resistance to microbial infections
Govoni, G. R., & Gros, P. (1998) · Inflammation Research · doi:10.1007/s000110050330 · Cited by 163 · see citing works
Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue.
Savidge, T., Mw, S., James, P. S., & Aldred, P. (1991) · PubMed Central · Cited by 151 · see citing works
Pathology of salmonella colitis
McGovern, V. J., & Slavutin, L. J. (1979) · The American Journal of Surgical Pathology · doi:10.1097/00000478-197912000-00001 · Cited by 150 · see citing works
Requirement for exported proteins in secretion through the invasion-associated type III system of Salmonella typhimurium
Collazo, C. M., & Galán, J. E. (1996) · Infection and Immunity · doi:10.1128/iai.64.9.3524-3531.1996 · Cited by 150 · see citing works
Of mice, calves, and men. Comparison of the mouse typhoid model with other Salmonella infections.
Tsolis, R. M., Kingsley, R. A., Townsend, S. M., Ficht, T. A., Adams, L. G., & Bäumler, A. J. (1999) · PubMed · Cited by 149 · see citing works
Mutation of invH , but Not stn , Reduces Salmonella -Induced Enteritis in Cattle
Watson, P. R., Galyov, E. E., Paulin, S. M., Jones, P. W., & Wallis, T. S. (1998) · Infection and Immunity · doi:10.1128/iai.66.4.1432-1438.1998 · Cited by 145 · see citing works
Of Mice, Calves, and Men
Tsolis, R. M., Kingsley, R. A., Townsend, S. M., Ficht, T. A., Adams, L. G., & Bäumler, A. J. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4143-1_28 · Cited by 143 · see citing works
Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus
Collazo, C. M., Zierler, M. K., & Gatan, J. E. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02218.x · Cited by 136 · see citing works
Growth of salmonellae in orally infected germfree mice
Collins, F. M., & Carter, P. B. (1978) · Infection and Immunity · doi:10.1128/iai.21.1.41-47.1978 · Cited by 134 · see citing works
Salmonella typhimurium secreted invasion determinants are homologous to Shigella lpa proteins
Hueck, C. J., Hantman, M. J., Bajaj, V., et al. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_18030479.x · Cited by 134 · see citing works
ALTERATIONS IN THE MOUSE CECUM AND ITS FLORA PRODUCED BY ANTIBACTERIAL DRUGS
Savage, D. C., & Dubos, R. J. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.1.97 · Cited by 133 · see citing works
Changes in the mouse's enteric microflora associated with enhanced susceptibility to Salmonella infection following streptomycin treatment*
Miller, C. P., & Bohnhoff, M. (1963) · The Journal of Infectious Diseases · doi:10.1093/infdis/113.1.59 · Cited by 128 · see citing works
Cellular routes of invasion by enteropathogens
Vázquez‐Torres, A. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00051-x · Cited by 122 · see citing works
Effect of streptomycin administration on colonization resistance to Salmonella typhimurium in mice
Que, J. U., & Hentges, D. J. (1985) · Infection and Immunity · doi:10.1128/iai.48.1.169-174.1985 · Cited by 120 · see citing works
Host restriction phenotypes of Salmonella typhi and Salmonella gallinarum
Pascopella, L., Raupach, B., Ghori, N., Monack, D. M., Falkow, S., & Small, P. L. C. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4329-4335.1995 · Cited by 106 · see citing works
Salmonella interactions with host cells: in vitro to in vivo
Finlay, B. B., & Brumell, J. H. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0603 · Cited by 106 · see citing works
Factors responsible for increased susceptibility of mice to intestinal colonization after treatment with streptomycin
Que, J. U., Casey, S. W., & Hentges, D. J. (1986) · Infection and Immunity · doi:10.1128/iai.53.1.116-123.1986 · Cited by 102 · see citing works
Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium
JONES, P., Dougan, G., Hayward, C., et al. (1991) · Vaccine · doi:10.1016/0264-410x(91)90313-u · Cited by 100 · see citing works
Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches
Debard, N., Sierro, F., Browning, J. L., & Kraehenbühl, J.-P. (2001) · Gastroenterology · doi:10.1053/gast.2001.22476 · Cited by 99 · see citing works
Pathology of the alimentary tract in Salmonella typhimurium food poisoning.
Boyd, J. F. (1985) · Gut · doi:10.1136/gut.26.9.935 · Cited by 97 · see citing works
Invasion Genes Are Not Required forSalmonella entericaSerovar Typhimurium To Breach the Intestinal Epithelium: Evidence ThatSalmonellaPathogenicity Island 1 Has Alternative Functions during Infection
Murray, R. A., & Lee, C. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.9.5050-5055.2000 · Cited by 93 · see citing works
Antagonistic effect of Lactobacillus acidophilus, Saccharomyces boulardii and Escherichia coli combinations against experimental infections with Shigella flexneri and Salmonella enteritidis subsp. typhimurium in gnotobiotic mice
Filho-Lima, J. V. M., Vieira, E., & Nicoli, J. R. (2000) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.00973.x · Cited by 93 · see citing works
Evaluation ofSalmonella typhimuriumMutants in a Model of Experimental Gastroenteritis
Everest, P. H., Ketley, J. M., Hardy, S. P., et al. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2815-2821.1999 · Cited by 78 · see citing works
Inoculum Composition and Salmonella Pathogenicity Island 1 Regulate M-Cell Invasion and Epithelial Destruction by Salmonella typhimurium
Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998) · Infection and Immunity · doi:10.1128/iai.66.2.724-731.1998 · Cited by 77 · see citing works
Rapid appearance of M cells after microbial challenge is restricted at the periphery of the follicle-associated epithelium of Peyer's patch.
Borghesi, C., Taussig, M. J., & Nicoletti, C. (1999) · PubMed · Cited by 71 · see citing works
Antibacterial mechanisms of the mouse gut. I. Kinetics of infection by Salmonella typhi-murium in normal and streptomycin-treated mice studied with abortive transductants.
Meynell, G. G., & Subbaiah, T. V. (1963) · PubMed · Cited by 67 · see citing works
The Ins and Outs of Body Surface Immunology
Hayday, A., & Viney, J. L. (2000) · Science · doi:10.1126/science.290.5489.97 · Cited by 57 · see citing works
SspA Is Required for LethalSalmonella entericaSerovar Typhimurium Infections in Calves but Is Not Essential for Diarrhea
Tsolis, R. M., Adams, L. G., Hantman, M. J., et al. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3158-3163.2000 · Cited by 53 · see citing works
Efficiency of various bacterial suspensions derived from cecal floras of conventional chickens in reducing the population level of Salmonella typhimurium in gnotobiotic mice and chicken intestines
Hudault, S., Bewa, H., Bridonneau, C., et al. (1985) · Canadian Journal of Microbiology · doi:10.1139/m85-155 · Cited by 40 · see citing works
Intragastric infection of germfree and conventional mice with Salmonella typhimurium.
Nardi, R. M. D., Silva, M. E., Ec, V., Bambirra, E. A., & Nicoli, J. R. (1989) · PubMed · Cited by 34 · see citing works
REVIEW ARTICLE. TELOMERES AND DISEASE
Royle, N. J. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199611)180:3 · Cited by 10 · see citing works
Colonization by Salmonella typhimurium and Shigella flexneri III of the gastrointestinal tract of mice treated with ?-2-thienylalanine and streptomycin
Brown, K. J., Tannock, G. W., Eyres, R. A., et al. (1979) · Antonie van Leeuwenhoek · doi:10.1007/bf00403653 · Cited by 7 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Meynell, G. G. 1955. Some factors affecting the resistance of mice to oral infection by Salmonella typhimurium. Proc. R. Soc. Med. 48:916-918.

Sorted by citations

Interactions between the microbiota and pathogenic bacteria in the gut
Bäumler, A. J., & Sperandio, V. (2016) · Nature · doi:10.1038/nature18849 · Cited by 1,420 · see citing works
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048 · see citing works
Self-citation
Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
Thaiss, C. A., Levy, M., Grosheva, I., Zheng, D., Soffer, E., Blacher, E., Braverman, S., Tengeler, A. C., Barak, O., Elazar, M., et al. (2018) · Science · doi:10.1126/science.aar3318 · Cited by 942 · see citing works
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works
Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
Rivera-Chávez, F., Zhang, L. F., Faber, F., Lopez, C. A., Byndloss, M. X., Olsan, E. E., Xu, G., Velazquez, E. M., Lebrilla, C. B., Winter, S. E., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.004 · Cited by 864 · see citing works
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works
The gut microbiome: connecting spatial organization to function
Tropini, C., Earle, K. A., Huang, K. C., & Sonnenburg, J. L. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.010 · Cited by 685 · see citing works
Salmonella, the host and disease: a brief review
Coburn, B., Grassl, G. A., & Finlay, B. B. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100007 · Cited by 690 · see citing works
Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
Bergstrom, K. S. B., Kissoon-Singh, V., Gibson, D. L., Ma, C., Montero, M., Sham, H. P., Ryz, N., Huang, T., Velcich, A., Finlay, B. B., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000902 · Cited by 625 · see citing works
Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron
Deriu, E., Liu, J. Z., Pezeshki, M., Edwards, R. A., Ochoa, R. J., Contreras, H., Libby, S. J., Fang, F. C., & Raffatellu, M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.007 · Cited by 550 · see citing works
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Carvalho, F. A., Koren, O., Goodrich, J. K., Johansson, M. E. V., Nalbantoglu, I., Aitken, J. D., Su, Y., Chassaing, B., Walters, W. A., González, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.07.004 · Cited by 548 · see citing works
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
Ejim, L., Farha, M. A., Falconer, S. B., Wildenhain, J., Coombes, B. K., Tyers, M., Brown, E. D., & Wright, G. D. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.559 · Cited by 525 · see citing works
Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine
Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525 · see citing works
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113246109 · Cited by 492 · see citing works
Self-citation
A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection
Jacobson, A., Lam, L., Rajendram, M., Tamburini, F., Honeycutt, J., Pham, T., Van Treuren, W., Pruss, K., Stabler, S. R., Lugo, K., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.07.002 · Cited by 507 · see citing works
Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation
Iljazovic, A., Roy, U., Gálvez, E. J. C., Lesker, T. R., Zhao, B., Gronow, A., Amend, L., Will, S. E., Hofmann, J. D., Pils, M. C., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-0296-4 · Cited by 454 · see citing works
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
Riglar, D. T., Giessen, T. W., Baym, M., Kerns, S. J., Niederhuber, M. J., Bronson, R. T., Kotula, J. W., Gerber, G. K., Way, J. C., & Silver, P. A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3879 · Cited by 426 · see citing works
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome
Chudnovskiy, A., Mortha, A., Kana, V., Kennard, A., Ramirez, J. D., Rahman, A., Remark, R., Mogno, I., Ng, R., Gnjatic, S., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.076 · Cited by 325 · see citing works
Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts
Lawley, T. D., Clare, S., Walker, A. W., Goulding, D., Stabler, R. A., Croucher, N., Mastroeni, P., Scott, P., Raisen, C., Mottram, L., et al. (2009) · Infection and Immunity · doi:10.1128/iai.00558-09 · Cited by 349 · see citing works
Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut
Liu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.017 · Cited by 328 · see citing works
Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons
Deriu, E., Boxx, G. M., He, X., Pan, C., Benavidez, S. D., Cen, L., Rozengurt, N., Shi, W., & Cheng, G. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005572 · Cited by 280 · see citing works
Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis
Yildiz, S., Mazel-Sanchez, B., Kandasamy, M., Manicassamy, B., & Schmolke, M. (2018) · Microbiome · doi:10.1186/s40168-017-0386-z · Cited by 264 · see citing works
Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
Ruder, B., Atreya, R., & Becker, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081887 · Cited by 228 · see citing works
“T phimurium induced colitis after streptomycin treatment, intestinal inflammation was also accompanied by increased levels of TNFα [134,135].”
Background
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition
Fulde, M., Sommer, F., Chassaing, B., van Vorst, K., Dupont, A., Hensel, M., Basic, M., Klopfleisch, R., Rosenstiel, P., Bleich, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0395-5 · Cited by 206 · see citing works
The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis
Zarepour, M., Bhullar, K., Montero, M., Ma, C., Huang, T., Velcich, A., Xia, L., & Vallance, B. A. (2013) · Infection and Immunity · doi:10.1128/iai.00854-13 · Cited by 206 · see citing works
Life in the inflamed intestine, Salmonella style
Santos, R. L., Raffatellu, M., Bevins, C. L., Adams, L. G., Tükel, Ç., Tsolis, R. M., & Bäumler, A. J. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2009.08.008 · Cited by 197 · see citing works
Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling
Schieber, A. M. P., Lee, Y. M., Chang, M. W., Leblanc, M., Collins, B., Downes, M., Evans, R. M., & Ayres, J. S. (2015) · Science · doi:10.1126/science.aac6468 · Cited by 189 · see citing works
Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration
Diaz-Ochoa, V. E., Lam, D., Lee, C. S., Klaus, S., Behnsen, J., Liu, J. Z., Chim, N., Nuccio, S.-P., Rathi, S. G., Mastroianni, J. R., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.005 · Cited by 164 · see citing works
Maintaining integrity under stress: Envelope stress response regulation of pathogenesis in gram-negative bacteria
Hews, C. L., Cho, T., Rowley, G., & Raivio, T. L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00313 · Cited by 168 · see citing works
Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome
Borton, M. A., Sabag-Daigle, A., Wu, J., Solden, L. M., O’Banion, B. S., Daly, R. A., Wolfe, R. A., Gonzalez, J. F., Wysocki, V. H., Ahmer, B. M. M., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0264-8 · Cited by 149 · see citing works
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice
Wang, L., Harrington, L., Trebicka, E., Shi, H. N., Kagan, J. C., Hong, C. C., Lin, H. Y., Babitt, J. L., & Cherayil, B. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39939 · Cited by 162 · see citing works
Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation
Wang, L., Johnson, E. E., Shi, H. N., Walker, W. A., Wessling-Resnick, M., & Cherayil, B. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2723 · Cited by 159 · see citing works
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair
Babbin, B. A., Laukoetter, M. G., Nava, P., Koch, S., Lee, W. Y., Capaldo, C. T., Peatman, E., Severson, E. A., Flower, R. J., Perretti, M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.5035 · Cited by 134 · see citing works
Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome
Ilyas, B., Tsai, C. N., & Coombes, B. K. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00428 · Cited by 128 · see citing works
Taming the Elephant: Salmonella Biology, Pathogenesis, and Prevention
Andrews-Polymenis, H. L., Bäumler, A. J., McCormick, B. A., & Fang, F. C. (2010) · Infection and Immunity · doi:10.1128/iai.00096-10 · Cited by 114 · see citing works
How flagellin and toll-like receptor 5 contribute to enteric infection
Steiner, T. S. (2007) · Infection and Immunity · doi:10.1128/iai.01506-06 · Cited by 97 · see citing works
TLR5 activation induces secretory interleukin-1 receptor antagonist (sIL-1Ra) and reduces inflammasome-associated tissue damage
Carvalho, F. A., Aitken, J. D., Gewirtz, A. T., & Vijay-Kumar, M. (2011) · Mucosal Immunology · doi:10.1038/mi.2010.57 · Cited by 80 · see citing works
Gut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77 · see citing works
Siderophore-based immunization strategy to inhibit growth of enteric pathogens
Sassone-Corsi, M., Chairatana, P., Zheng, T., Perez-Lopez, A., Edwards, R. A., George, M. D., Nolan, E. M., & Raffatellu, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606290113 · Cited by 75 · see citing works
Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis
Chandrasekharan, B., Bala, V., Kolachala, V. L., Vijay-Kumar, M., Jones, D., Gewirtz, A. T., Sitaraman, S. V., & Srinivasan, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003304 · Cited by 70 · see citing works
Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium
Costa, L. F., Mol, J. P. S., Silva, A. P. C., Macêdo, A. A., Silva, T. M. A., Alves, G. E. S., Winter, S., Winter, M. G., Velazquez, E. M., Byndloss, M. X., et al. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.10.004 · Cited by 29 · see citing works
A precious metal heist
Skaar, E. P. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.005 · Cited by 7 · see citing works

Porcine salmonellosis
Lawson, G. H. K., & Dow, C. (1966) · Journal of Comparative Pathology · doi:10.1016/0021-9975(66)90056-9 · Cited by 30 · see citing works
Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis
Olli, K. E., Rapp, C., O’Connell, L., Collins, C. B., McNamee, E. N., Jensen, O., Jedlicka, P., Allison, K. C., Goldberg, M. S., Gerich, M. E., et al. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa064 · Cited by 45 · see citing works
Sarcodon aspratus Extract Ameliorates Dextran Sulfate Sodium‐Induced Colitis in Mouse Colon and Mesenteric Lymph Nodes
Chung, M., Hwang, J., Kim, J. H., et al. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13297 · Cited by 5 · see citing works
Gamma Irradiation or CD4+-T-Cell Depletion Causes Reactivation of LatentSalmonella entericaSerovar Typhimurium Infection in C3H/HeN Mice
van Diepen, A., van de Gevel, J. S., Koudijs, M. M., OSSENDORP, F. A., Beekhuizen, H., Janssen, R., & van Dissel, J. T. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.2857-2862.2005 · Cited by 20 · see citing works
c-Fos-Deficient Mice Are Susceptible to Salmonella enterica Serovar Typhimurium Infection
Maruyama, K., Sano, G., Ray, N., Takada, Y., & Matsuo, K. (2006) · Infection and Immunity · doi:10.1128/iai.01316-06 · Cited by 28 · see citing works

Authors: Barthel, M., Hapfelmeier, S., Quintanilla-Martínez, L., Kremer, M., Rohde, M., Hogardt, M., Pfeffer, K., Rüssmann, H., & Hardt, W.-D.
Affiliations: ETH Zurich (CH)
GSF-Research Center for Environment and Health, 85764 Neuherberg
Helmholtz Munich (DE)
Helmholtz Centre for Infection Research (DE)
Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie (DE)
Technical University of Munich (DE)
Max von Pettenkofer-Institut, Ludwig Maximilians Universität, 80336 Munich
Corresponding author: Hardt, Wolf-Dietrich
ORCID: Barthel, Manja
Hapfelmeier, Siegfried
Rohde, Manfred
Hogardt, Michael
Pfeffer, Klaus
Hardt, Wolf-Dietrich
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2003-05
Volume: 71
Issue: 5
Pages: 2839-2858
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.71.5.2839-2858.2003
PMC: PMC153285
OpenAlex: W2124519481
Cited by: 1,020
References: 86
Citations by year: 2026: 44 · 2025: 67 · 2024: 61 · 2023: 61 · 2022: 64 · 2021: 71 · 2020: 72 · 2019: 59 · 2018: 58 · 2017: 46 · 2016: 51 · 2015: 46 · 2014: 52 · 2013: 45 · 2012: 31
FWCI: 21.12
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HZI (Helmholtz Centre for Infection Research) (submittedVersion)
Bern Open Repository and Information System (University of Bern) (submittedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Volkswagen Foundation
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Salmonella typhimurium, colitis, mouse model, type III secretion system, SPI-1, Peyer's patches, mesenteric lymph nodes, lymphotoxin beta receptor, ICAM-1, neutrophil infiltration, host-pathogen interaction
MeSH terms: Animals, Bacterial Proteins, Colitis, Disease Models, Animal, Female, Intestines, Lactobacillus, Lymphoid Tissue, Mice, Inbred C57BL, Peyer's Patches, Salmonella Infections, Animal, Salmonella typhimurium, Streptomycin, Receptors, Tumor Necrosis Factor, Mice, Lymphotoxin beta Receptor

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Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

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