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MyD88‐Dependent Immune Response Contributes to Hearing Loss in Experimental Pneumococcal Meningitis

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Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology

Buerki, S. E., Grandgirard, D., Datta, A., Hackenberg, A., Martin, F., Schmitt‐Mechelke, T., Leib, S. L., & Steinlin, M. I. (2015) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2015.12.006 · Cited by 24 · see citing works

Porphyromonas gingivalis stimulates TACE production by T cells

Bostancı, N., Reddi, D., Rangarajan, M., Curtis, M. A., & Belibasakis, G. N. (2009) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00488.x · Cited by 24 · see citing works

Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis

Muri, L., Perny, M., Zemp, J., Grandgirard, D., & Leib, S. L. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00220-19 · Cited by 23 · see citing works

The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis

Liechti, F. D., Bächtold, F., Grandgirard, D., Leppert, D., & Leib, S. L. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0257-0 · Cited by 22 · see citing works

Bacterial meningitis: new treatment options to reduce the risk of brain damage

Principi, N., & Esposito, S. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1685497 · Cited by 22 · see citing works

Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction

Rice, A. C., Chiou, V. L., Zuckoff, S. B., & Shapiro, S. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.052 · Cited by 21 · see citing works

Impaired learning and memory in male mice induced by sodium arsenite was associated with MMP-2/MMP-9-mediated blood-brain barrier disruption and neuronal apoptosis

Cheng, L., Zhang, Y., Lv, M., Huang, W., Zhang, K., Guan, Z., Feng, X., Yang, Y., Gao, Y., & Liu, X. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117016 · Cited by 20 · see citing works

Brain Edema and Disorders of Cerebrospinal Fluid Circulation

Rosenberg, G. A. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-7525-3.50101-1 · Cited by 20 · see citing works

The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis

Liechti, F. D., Grandgirard, D., & Leib, S. L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.056 · Cited by 18 · see citing works

Enhanced Allograft Survival and Modulation of T-Cell Alloreactivity Induced by Inhibition of MMP/ADAM Enzymatic Activity

Eaton, V. L., Lerret, N. M., Velásquez‐Lopera, M. M., John, R. W. G., Caicedo, M. S., DeCresce, R. P., & Jaramillo, A. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02097.x · Cited by 18 · see citing works

Doxycycline Treatment Decreases Morbidity and Mortality of Murine Neurocysticercosis

Alvarez, J. I., Krishnamurthy, J., & Teale, J. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081073 · Cited by 18 · see citing works

Acute Meningitis

Tunkel, A. R., van de Beek, D., & Scheld, W. M. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00089-8 · Cited by 18 · see citing works

Novel and preclinical treatment strategies in pneumococcal meningitis

Bewersdorf, J. P., Grandgirard, D., Koedel, U., & Leib, S. L. (2017) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000416 · Cited by 17 · see citing works

The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial

Mansour, N. O., Shama, M. A., & Werida, R. H. (2021) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223211024362 · Cited by 17 · see citing works

Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies

Boardman, S., Hetherington, C., Hughes, T., Cook, C., Galea, I., Hilton, O., Solomon, T., Luster, A. D., Allan, S. M., Kurt‐Jones, E. A., et al. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf455 · Cited by 16 · see citing works

Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study

Vermeij, J., Westendorp, W. F., Roos, Y. B. W. E. M., Brouwer, M. C., van de Beek, D., Nederkoorn, P. J., & for the PASS Investigators (2016) · Cerebrovascular Diseases · doi:10.1159/000446160 · Cited by 15 · see citing works

Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures

Perny, M., Sołyga, M., Grandgirard, D., Roccio, M., Leib, S. L., & Senn, P. (2017) · Hearing Research · doi:10.1016/j.heares.2017.04.012 · Cited by 15 · see citing works

Quantitative evaluation of blood–cerebrospinal fluid barrier permeability in the rat with experimental meningitis using magnetic resonance imaging

Ichikawa, H., Ishikawa, M., Fukunaga, M., Ishikawa, K., & Ishiyama, H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.050 · Cited by 15 · see citing works

Acute Meningitis

Tunkel, A. R., van de Beek, D., & Scheld, W. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06839-3.00084-9 · Cited by 15 · see citing works

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation

Haify, S. N., Buijsen, R. A. M., Verwegen, L., Severijnen, L.-A. W. F. M., de Boer, H., Boumeester, V., Monshouwer, R., Yang, W., Cameron, M. D., Willemsen, R., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab143 · Cited by 14 · see citing works

Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis

Erni, S. T., Fernandes‐Pires, G., Buri, M. C., Perny, M., Rutten, R. J., van Noort, J. M., Senn, P., Grandgirard, D., Roccio, M., & Leib, S. L. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00570 · Cited by 14 · see citing works

Community-acquired acute bacterial meningitis in adults: a clinical update

Ellis, J., Luintel, A., Chandna, A., & Heyderman, R. S. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz023 · Cited by 12 · see citing works

A model of cerebral aspergillosis in non-immunosuppressed nursing rats

Zimmerli, S., Knecht, U., & Leib, S. L. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0255-0 · Cited by 12 · see citing works

Bacterial Infections of the Central Nervous System

Tessier, J. M., & Scheld, W. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397169-2.00096-2 · Cited by 10 · see citing works

Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study

Munyeza, C. F., Shobo, A., Baijnath, S., Bratkowska, D., Naiker, S., Bester, L. A., Singh, S. D., Maguire, G. E. M., Kruger, H. G., Naicker, T., et al. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1081307 · Cited by 9 · see citing works

Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis

Liu, X., Han, Q., & Leng, J. (2014) · BMC Infectious Diseases · doi:10.1186/s12879-014-0648-3 · Cited by 9 · see citing works

Long-term Stabilization of Aqueous Doxycycline Formulations, in Mucoadhesive Hydrogels for Treatment of Oral Mucosal Conditions

Patlolla, V. G. R., Holbrook, W. P., Gizurarson, S. S., & Kristmundsdottir, T. (2019) · Current Drug Discovery Technologies · doi:10.2174/1570163816666190222193902 · Cited by 9 · see citing works

Central Nervous System Antimicrobial Exposure and Proposed Dosing for Anthrax Meningitis

Bradley, J. S., Bulitta, J. B., Cook, R., Yu, P. A., Iwamoto, C., Hesse, E. M., Chaney, D., Yu, Y., Kennedy, J. L., Sue, D., et al. (2024) · Clinical Infectious Diseases · doi:10.1093/cid/ciae093 · Cited by 8 · see citing works

Brain Edema and Disorders of Cerebrospinal Fluid Circulation

Rosenberg, G. A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0434-1.00084-0 · Cited by 8 · see citing works

The Impact of Doxycycline as an Adjunctive Therapy on Prostate-Specific Antigen, Quality of Life, and Cognitive Function in Metastatic Prostate Cancer Patients: A Phase II Randomized Controlled Trial

Guzmán-Esquivel, J., Garcia-Garcia, H. S., Hernández‐Fuentes, G. A., Venegas-Ramírez, J., Barajas-Mejía, C. D., Veloz, I. G., Martínez‐Fierro, M. L., Magaña-Vergara, N. E., Guzmán-Solórzano, J. A., Calvo-Soto, P., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17040404 · Cited by 7 · see citing works

The tale of antibiotics beyond antimicrobials: Expanding horizons

Yadav, S., Shah, D., Dalai, P., & Agrawal-Rajput, R. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156285 · Cited by 7 · see citing works

Association of rs12722 COL5A1 with pulmonary tuberculosis: a preliminary case-control study in a Kazakhstani population

Zhetkenev, S., Khassan, A., Khamzina, A., Issanov, A., Crape, B. L., Akilzhanova, A. R., Yerezhepov, D., Kozhamkulov, U. A., & Chan, C. K. (2021) · Molecular Biology Reports · doi:10.1007/s11033-020-06121-y · Cited by 7 · see citing works

Doxycycline reduces nitric oxide production in guinea pig inner ears

Helling, K., Wodarzcyk, K., Brieger, J., Schmidtmann, I. M., Li, H., Mann, W. J., & Heinrich, U. (2011) · Auris Nasus Larynx · doi:10.1016/j.anl.2011.02.013 · Cited by 6 · see citing works

Oral Doxycycline on the Level of Matrix Metalloproteinase 9 in Rat Models Experiencing Traumatic Brain Injury

Faruk, M., Daud, K. R., Islam, A. A., Ihwan, A., & Alfian Zainuddin, A. A. (2020) · IIUM Medical Journal Malaysia · doi:10.31436/imjm.v20i1.1773 · Cited by 6 · see citing works

Adjunctive treatments for pneumococcal meningitis: a systematic review of experimental animal models

Koning, R., van ROON, M. A., Brouwer, M. C., & van de Beek, D. (2024) · Brain Communications · doi:10.1093/braincomms/fcae131 · Cited by 5 · see citing works

Doxycycline cotherapy with albendazole relieves neural function damage in C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis

Sofiyatun, E., Chen, K.-Y., Chou, C.-J., Lee, H.-C., Day, Y.-A., Chiang, P.-J., Chiu, C., Chen, W., Jhan, K.-Y., & Wang, L.-C. (2024) · Biomedical Journal · doi:10.1016/j.bj.2024.100727 · Cited by 4 · see citing works

Interplays Between Matrix Metalloproteinases and Neurotropic Viruses: An Overview

Alghamdi, S. A., Alissa, M., Alghamdi, A., Alshehri, M. A., Albelasi, A., Alzahrani, K. J., & Safhi, A. Y. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2585 · Cited by 4 · see citing works

N-glycosylation negatively regulates the expression of tumor necrosis factor (TNF) in mouse macrophage

Murakami, M., Onizawa, M., Abe, N., Mochimaru, T., Saito, C., Hikichi, R., Uemura, T., Sekimata, M., & Ohira, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150897 · Cited by 3 · see citing works

A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis

Fisher, J., Pavan, C., Ohlmeier, L., Nilson, B., Lundgaard, I., Linder, A., & Bentzer, P. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00331-1 · Cited by 3 · see citing works

The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis

Le, N. D., Steinfort, M., Grandgirard, D., Maleska, A., Leppert, D., Kühle, J., & Leib, S. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-17282-0 · Cited by 3 · see citing works

Basic Science of Central Nervous System Infections

Tessier, J. M., & Scheld, W. M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5316-3.00040-x · Cited by 3 · see citing works

Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

Ricci, S., Grandgirard, D., Masouris, I., Braccini, T., Pozzi, G., Oggioni, M. R., Koedel, U., & Leib, S. L. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05226-w · Cited by 3 · see citing works

Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich

Hu, J., Zhou, J., Wang, L., Chen, Z., Tan, Y., Yin, Y., Pei, Z., Li, C., Bai, H., Ma, C., et al. (2025) · Veterinary Sciences · doi:10.3390/vetsci12090793 · Cited by 1 · see citing works

Antibiothérapie d’une méningite présumée bactérienne adulte (rationnel, modalités, durée, suivi)

Ansart, S. (2009) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2009.02.015 · Cited by 1 · see citing works

Neonatal Meningitis Mechanisms and Implications in Adult Life

Giridharan, V. V., Simões, L. R., Sayana, P., Petronilho, F. C., Hasbun, R., & Barichello, T. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-39335-9_6 · Cited by 1 · see citing works

Bacterial infections of the central nervous system

Tessier, J., & Scheld, W. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-4064-1.00050-6 · Cited by 1 · see citing works

Matrix metalloproteinases in critically ill patients

Hästbacka, J. (2013) · Työväentutkimus Vuosikirja

The effect of cell wall structure on pneumococcal virulence

Gehre, F. (2010) · doi:10.18452/16091

Sequentielle Antibiose mit Rifampicin gefolgt von Ceftriaxon als neuroprotektiver Therapieansatz bei der bakteriellen Meningitis

Stoltefaut, V. (2016) · doi:10.53846/goediss-5713

Quantifizierung der Freisetzung bakterieller DNA in Modellen experimenteller bakterieller Meningitis

Hoecht, A. (2012) · doi:10.53846/goediss-1629

Research news and notes

Roitberg, B. Z. (2006) · Surgical Neurology · doi:10.1016/j.surneu.2006.06.045

BACTERIAL MENINGITIS

van de Beek, D., Weisfelt, M., & de Gans, J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3291-5.50084-6

The Effect of Doxycycline on Matrix Metalloproteinase-9 Levels in the Colon of Wistar Rats with Obstructive Ileus

Ulfandi, D., Labeda, I., Syarifuddin, E., Zainuddin, A. A., & Faruk, M. (2024) · IIUM Medical Journal Malaysia · doi:10.31436/imjm.v23i01.2370

Albendazole–doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis

Jhan, K.-Y., Sofiyatun, E., Chiu, S.-C., Chou, C.-J., Day, Y.-A., Chiang, P.-J., Jung, S.-M., Chen, W., Cheng, P.-C., & Wang, L.-C. (2026) · Parasites & Vectors · doi:10.1186/s13071-026-07284-6

Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage and Hearing Loss in Infant Rat Pneumococcal Meningitis.

Muri, L., Perny, M., Zemp, J., Grandgirard, D., & Leib, S. L. (2019) · Open Access CRIS of the University of Bern · doi:10.7892/boris.130593

Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

Muri, L., Grandgirard, D., Buri, M. C., Perny, M., & Leib, S. L. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1272-8 · Cited by 39 · see citing works

Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

Ricci, S., Grandgirard, D., Masouris, I., Braccini, T., Pozzi, G., Oggioni, M. R., Koedel, U., & Leib, S. L. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05226-w · Cited by 3 · see citing works

Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis

Leib, S. L. (2001) · Brain · doi:10.1093/brain/124.9.1734 · Cited by 228 · see citing works

Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.

Muri, L., Le, N. D., Zemp, J., Grandgirard, D., & Leib, S. L. (2019) · Open Access CRIS of the University of Bern · doi:10.7892/boris.133327