Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

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Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

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Intracellular amyloid-β in Alzheimer's disease

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Mechanisms, challenges and opportunities in stroke

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Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

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The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

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Strategies for MMP inhibition in cancer: innovations for the post-trial era

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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

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Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

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Processing of tumour necrosis factor-α precursor by metalloproteinases

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Metalloproteinase inhibitors: biological actions and therapeutic opportunities

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Activation mechanisms of matrix metalloproteinases.

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Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia

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S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

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Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

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Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

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Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases

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Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

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White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

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Metalloproteinases: Mediators of Pathology and Regeneration in the CNS

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Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

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Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

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Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging

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The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

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A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia

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Multiple roles for MMPs and TIMPs in cerebral ischemia

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Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

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The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases

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Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

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Matrix Metalloproteinase-9 Degrades Amyloid-β Fibrils in Vitro and Compact Plaques in Situ

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Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

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Vascular Matrix Metalloproteinase-2 Cleaves Big Endothelin-1 Yielding a Novel Vasoconstrictor

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Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

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Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)–Induced Hemorrhage After Thromboembolic Stroke

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Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-β peptide (1–40).

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Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

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Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling

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Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration

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Matrix metalloproteinases degrade myelin basic protein

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Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study

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Involvement of Matrix Metalloproteinase in Neuroblast Cell Migration from the Subventricular Zone after Stroke

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Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: a possible mechanism of inflammatory demyelination.

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Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

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Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

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Matrix Metalloproteinase-3: A Novel Signaling Proteinase from Apoptotic Neuronal Cells That Activates Microglia

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Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion

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Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

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Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis

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Recent advances in MMP inhibitor design

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Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation.

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Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease.

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Remarkable roles of proteolysis on and beyond the cell surface

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Binswanger's disease--revisited

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Long-Term Doxycycline Is More Effective Than Atenolol to Prevent Thoracic Aortic Aneurysm in Marfan Syndrome Through the Inhibition of Matrix Metalloproteinase-2 and -9

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Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

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White matter damage is associated with matrix metalloproteinases in vascular dementia

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Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer’s disease patients

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Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-α in the Rat

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Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

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Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the αvβ1 Integrin and Focal Adhesion Kinase Signaling Pathway

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Minocycline reduces gadolinium‐enhancing magnetic resonance imaging lesions in multiple sclerosis

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Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1

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Pathogenesis of Binswanger chronic progressive subcortical encephalopathy

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Increased Production of Matrix Metalloproteinases in Enriched Astrocyte and Mixed Hippocampal Cultures Treated with β‐Amyloid Peptides

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Abnormal Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Brain Arteriovenous Malformations

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Matrix Metalloproteinase-2 Plays a Critical Role in the Pathogenesis of White Matter Lesions After Chronic Cerebral Hypoperfusion in Rodents

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The APP family of proteins: similarities and differences

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Angiogenic Recruitment of Pericytes from Bone Marrow after Stroke

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Modern concept of vascular cognitive impairment

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Measurement of Gelatinase B (MMP-9) in the Cerebrospinal Fluid of Patients With Vascular Dementia and Alzheimer Disease

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Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

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Silencing hypoxia-inducible factor-1α inhibits cell migration and invasion under hypoxic environment in malignant gliomas

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Tissue Inhibitor of Metalloproteinase-3 Induces a Fas-associated Death Domain-dependent Type II Apoptotic Pathway

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Transcriptional responses to intermittent hypoxia

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Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer’s disease brain

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Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change

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A novel intracellular role of matrix metalloproteinase‐3 during apoptosis of dopaminergic cells

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Doxycycline Suppresses Cerebral Matrix Metalloproteinase-9 and Angiogenesis Induced by Focal Hyperstimulation of Vascular Endothelial Growth Factor in a Mouse Model

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Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter

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Angiopoietin-2 Facilitates Vascular Endothelial Growth Factor-Induced Angiogenesis in the Mature Mouse Brain

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Early Beneficial Effect of Matrix Metalloproteinase Inhibition on Blood—Brain Barrier Permeability as Measured by Magnetic Resonance Imaging Countered by Impaired Long-Term Recovery after Stroke in Rat Brain

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The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.

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Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Promoter Polymorphisms Are Associated With Carotid Artery Stenosis

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Intrathecal synthesis of matrix metalloproteinase-9 in patients with multiple sclerosis: implication for pathogenesis

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Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand.

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Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation

Conant, K. E., Wang, Y., Szklarczyk, A., Dudak, A., Mattson, M. P., & Lim, S. T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.061 · Cited by 110 · see citing works

The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications

Kim, S., Jung, U. J., & Kim, S. R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020386 · Cited by 123 · see citing works

Berberine Attenuates Experimental Autoimmune Encephalomyelitis in C57 BL/6 Mice

Ma, X., Jiang, Y., Wu, A., Chen, X., Pi, R., Liu, M., & Liu, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013489 · Cited by 110 · see citing works

New strategies for targeting matrix metalloproteinases

Fields, G. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.002 · Cited by 107 · see citing works

Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia

Lee, Y. Y., Lee, E.-J., Park, J., Jang, S., Kim, D., & Kim, H.-S. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9657-x · Cited by 107 · see citing works

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats

Kanazawa, M., Miura, M., Toriyabe, M., Koyama, M., Hatakeyama, M., Ishikawa, M., Nakajima, T., Onodera, O., Takahashi, T., Nishizawa, M., et al. (2017) · Scientific Reports · doi:10.1038/srep42582 · Cited by 106 · see citing works

Matrix metalloproteinases as therapeutic targets in protozoan parasitic infections

Geurts, N., Opdenakker, G., & den Steen, P. E. V. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.008 · Cited by 104 · see citing works

Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development

Bronisz, E., & Kurkowska‐Jastrzębska, I. (2016) · Mediators of Inflammation · doi:10.1155/2016/7369020 · Cited by 105 · see citing works

Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

Stomrud, E., Björkqvist, M., Janciauskiene, S. M., Minthon, L., & Hansson, O. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt44 · Cited by 105 · see citing works

Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood–brain barrier model

Labus, J., Häckel, S., Lucka, L., & Danker, K. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.002 · Cited by 104 · see citing works

MMPs in the Trabecular Meshwork: Promising Targets for Future Glaucoma Therapies?

Groef, L. D., Hove, I. V., Dekeyster, E., Stalmans, I., & Moons, L. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13088 · Cited by 104 · see citing works

Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways

Ranaivo, H. R., Hodge, J. N., Choi, N., & Wainwright, M. S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-68 · Cited by 104 · see citing works

Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia

Weekman, E. M., & Wilcock, D. M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150759 · Cited by 103 · see citing works

Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds

Miwa, K., Tanaka, M. R., Okazaki, S., Furukado, S., Sakaguchi, M., & Kitagawa, K. (2011) · Stroke · doi:10.1161/strokeaha.111.621193 · Cited by 99 · see citing works

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works

The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders

Costea, L., Mészáros, Á., Bauer, H., Bauer, H., Traweger, A., Wilhelm, I., Farkas, A. E., & Krizbai, I. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215472 · Cited by 98 · see citing works

MMP-9, a Potential Target for Cerebral Ischemic Treatment

Dong, X., Song, Y., Liu, W., & Guo, X. (2009) · Current Neuropharmacology · doi:10.2174/157015909790031157 · Cited by 97 · see citing works

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Andresen, T. L., Bruun, J., Larsen, T. B., Jølck, R. I., Eliasen, R., Holm, R., & Gjetting, T. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87334 · Cited by 96 · see citing works

Biomimetic Approaches for Bone Tissue Engineering

Ng, J., Spiller, K. L., Bernhard, J., & Vunjak‐Novakovic, G. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0289 · Cited by 94 · see citing works

Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges

Zipfel, P., Rochais, C., Baranger, K., Rivera, S., & Dallemagne, P. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00352 · Cited by 94 · see citing works

Recent Updates on Subcortical Ischemic Vascular Dementia

Roh, J. H., & Lee, J.-H. (2014) · Journal of Stroke · doi:10.5853/jos.2014.16.1.18 · Cited by 93 · see citing works

Smoking and Endothelial Dysfunction

Golbidi, S., Edvinsson, L. I., & Laher, I. (2018) · Current Vascular Pharmacology · doi:10.2174/1573403x14666180913120015 · Cited by 96 · see citing works

A new face for old antibiotics: tetracyclines in treatment of amyloidoses.

Stoilova, T., Colombo, L., Forloni, G., Tagliavini, F., & Salmona, M. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400161p · Cited by 89 · see citing works

Intrathecal Delivery of Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets in SOD1 Rats and Amends the Course of ALS

Forostyak, S., Homola, A., Turnovcová, K., Svítil, P., Jendelová, P., & Syková, E. (2014) · Stem Cells · doi:10.1002/stem.1812 · Cited by 92 · see citing works

Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Niebrój-Dobosz, I., Janik, P., Sokołowska, B., & Kwieciński, H. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02775.x · Cited by 91 · see citing works

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

Lee, E.-J., Ko, H.-M., Jeong, Y.-H., Park, E.-M., & Kim, H.-S. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0355-z · Cited by 91 · see citing works

Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation

Lee, E.-J., Han, J. E., Woo, M.-S., Shin, J. A., Park, E., Kang, J. L., Moon, P. G., Baek, M., Son, W.-S., Ko, Y. T., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303240 · Cited by 90 · see citing works

Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer’s disease

JIANG, P., Li, C., Xiang, Z., & Jiao, B. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2254 · Cited by 89 · see citing works

Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases

Wang, M., Xie, Y., & Qin, D. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.11.005 · Cited by 93 · see citing works

Matrix Metalloproteinases in Alzheimer’s Disease and Concurrent Cerebral Microbleeds

Duits, F., Hernández-Guillamon, M., Montaner, J., Goos, J. D. C., Montañola, A., Wattjes, M., Barkhof, F., Scheltens, P., Teunissen, C., & van der Flier, W. M. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-143186 · Cited by 82 · see citing works

Review Matrix

(2009)

Multiple Roles of Metalloproteinases in Neurological Disorders

Yang, Y. R., Hill, J. W., & Rosenberg, G. A. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385504-6.00006-3 · Cited by 62 · see citing works

Implication of matrix metalloproteinases in regulating neuronal disorder

Mukherjee, A., & Swarnakar, S. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3752-y · Cited by 27 · see citing works

The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Pathophysiology of Neurodegeneration: A Literature Study

Mroczko, B., Groblewska, M., & Barcikowska, M. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130647 · Cited by 61 · see citing works

Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders

Kim, Y.-S., & Joh, T. H. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.133 · Cited by 103 · see citing works