Growth rates of Actinomyces viscosus and Streptococcus mutans during early colonization of tooth surfaces in gnotobiotic rats
Open accessAbstract
Germfree Osborne-Mendel rats were monoassociated with Actinomyces viscosus or Streptococcus mutans. The adherence and subsequent growth of these organisms on the tooth surface was studied by means of total viable cell counts. Both A. viscosus and S. mutans showed a lag phase and an exponential growth phase, similar to logarithmic growth in batch cultures. The exponential growth rates of S. mutans and A. viscosus were 0.63 h-1 (doubling time [td] = 1.1 h) and 0.24 h-1 (td = 2.9 h), respectively. After a period of rapid growth, the rate declined and the populations approached a steady state. The presence of a sucrose-containing diet did not significantly influence the exponential growth rates of A. viscosus and S. mutans, but had a slight negative effect on the initial adherence of S. mutans at the tooth surface.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent human studies have shown no difference in the growth rates of oral bacteria in the presence or absence of food, indicating no relationship between diet and the composition of oral bacterial communities.
“Recent human studies have shown no difference in the growth rates of oral bacteria in the presence or absence of food, indicating no relationship between diet and the composition of oral bacterial communities [60,61].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [61]
Cites
Biology, immunology, and cariogenicity of Streptococcus mutans
Hamada, S., & Slade, H. D. (1980) · Microbiological Reviews · doi:10.1128/mr.44.2.331-384.1980 · Cited by 1,907 · see citing works
The Effect of Solid Surfaces upon Bacterial Activity
ZoBell, C. E. (1943) · Journal of Bacteriology · doi:10.1128/jb.46.1.39-56.1943 · Cited by 1,003 · see citing works
BACTERIAL ADHERENCE IN ORAL MICROBIAL ECOLOGY
Gibbons, R. J., & van Houte, J. (1975) · Annual Review of Microbiology · doi:10.1146/annurev.mi.29.100175.000315 · Cited by 864 · see citing works
Bacteriological studies of developing supragingival dental plaque
Socransky, S. S., Manganiello, A. D., Propas, D., Oram, V., & van Houte, J. (1977) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1977.tb00112.x · Cited by 320 · see citing works
Microbial Selection in Continuous Culture
Harder, W., Kuenen, J. G., & Matin, A. (1977) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1977.tb00717.x · Cited by 181 · see citing works
EFFECT OF DIET ON EARLY PLAQUE FORMATION IN MAN.
Carlsson, J., & Egelberg, J. H. (1965) · PubMed · Cited by 163 · see citing works
Adherence as an ecological determinant for streptococci in the human mouth
van Houte, J., Gibbons, R. J., & Pulkkinen, A. J. (1971) · Archives of Oral Biology · doi:10.1016/0003-9969(71)90042-2 · Cited by 152 · see citing works
Microbial growth rates in nature
Brock, T. D. (1971) · Bacteriological Reviews · doi:10.1128/br.35.1.39-58.1971 · Cited by 149 · see citing works
Implantation of caries-inducing streptococci in the human oral cavity
Krasse, B., EDWARDSSON, S., Svensson, I., et al. (1967) · Archives of Oral Biology · doi:10.1016/0003-9969(67)90042-8 · Cited by 140 · see citing works
CLARK, W. B., & Gibbons, R. J. (1977) · Infection and Immunity · doi:10.1128/iai.18.2.514-523.1977 · Cited by 127 · see citing works
Krasse, B. (1954) · PubMed · Cited by 122 · see citing works
Ellen, R. P. (1976) · Infection and Immunity · doi:10.1128/iai.14.5.1119-1124.1976 · Cited by 114 · see citing works
Gibbons, R. J. (1964) · Journal of Dental Research · doi:10.1177/00220345640430060301 · Cited by 94 · see citing works
Role of Sucrose in Colonization of Streptococcus mutans in Conventional Sprague-Dawley Rats
van Houte, J., Upeslacis, V. N., Jordan, H. V., et al. (1976) · Journal of Dental Research · doi:10.1177/00220345760550020801 · Cited by 77 · see citing works
Martin, E. J. S., & Wittenberger, C. L. (1979) · Infection and Immunity · doi:10.1128/iai.24.3.865-868.1979 · Cited by 77 · see citing works
Bacteriocinogeny and the properties of some bacteriocins of streptococcus mutans
Rogers, A. H. (1976) · Archives of Oral Biology · doi:10.1016/0003-9969(76)90079-0 · Cited by 73 · see citing works
The acquired pellicle: Variability and subject‐dependence of specific proteins
Kraus, F. W., Ørstavik, D., Hurst, D. C., & Cook, C. H. (1973) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1973.tb01680.x · Cited by 47 · see citing works
Antibody-Mediated Inhibition of Dextran/Sucrose-Induced Agglutination of Streptococcus mutans
Olson, G. A., Guggenheim, B., & Small, P. A. (1974) · Infection and Immunity · doi:10.1128/iai.9.2.273-278.1974 · Cited by 47 · see citing works
A Slime-Producing Microorganism in Dental Plaque of Rats, Selected by Glucose Feeding
van der Hoeven, J. S. (2009) · Caries Research · doi:10.1159/000260109 · Cited by 37 · see citing works
Cowman, R. A., Schaefer, S. J., FITZGERALD, R. J., et al. (1979) · Journal of Dental Research · doi:10.1177/00220345790580101501 · Cited by 32 · see citing works
Iodophilic polysaccharide synthesis, acid production and growth in oral streptococci
van Houte, J., Kc, W., & Jansen, H. M. (1969) · Archives of Oral Biology · doi:10.1016/0003-9969(69)90020-x · Cited by 29 · see citing works
Slee, A., & Tanzer, J. M. (1979) · Infection and Immunity · doi:10.1128/iai.26.2.783-786.1979 · Cited by 21 · see citing works
Brecher, S. M., & van Houte, J. (1979) · Infection and Immunity · doi:10.1128/iai.26.3.1137-1145.1979 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Resilience of the oral microbiome
Wade, W. G. (2021) · Periodontology 2000 · doi:10.1111/prd.12365 · Cited by 205 · see citing works
Santonocito, S., Giudice, A., Polizzi, A., Troiano, G., Merlo, E. M., Sclafani, R., Grosso, G., & Isola, G. (2022) · Nutrients · doi:10.3390/nu14122426 · Cited by 144 · see citing works
Physiological Approaches to the Control of Oral Biofilms
Marsh, P. D., & Bradshaw, D. J. (1997) · Advances in Dental Research · doi:10.1177/08959374970110010901 · Cited by 132 · see citing works
- Authors
- Beckers, H. J., & van der Hoeven, J. S.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1982-02
- Volume
- 35
- Issue
- 2
- Pages
- 583-587
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC351080
- OpenAlex
- W1868152069
- Cited by
- 65
- References
- 23
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2014: 1 · 2012: 2
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- Actinomyces viscosus, Streptococcus mutans, bacterial growth rate, gnotobiotic rats, germ-free rats, monoassociation, lag phase, exponential growth, sucrose diet, dental plaque
- MeSH terms
- Actinomyces, Adhesiveness, Animals, Diet, Cariogenic, Germ-Free Life, Kinetics, Starvation, Streptococcus mutans, Tooth, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
