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Cited by 253

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection

Open access
Winner, L, Mack, J, Weltzin, R, Mekalanos, J J, Kraehenbuhl, J P, Neutra, M R·1991·Infection and Immunity
DOI 10.1128/iai.59.3.977-982.1991
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Abstract

Secretory immunoglobulin A (sIgA) plays a role in defense against Vibrio cholerae and other microorganisms that infect mucosal surfaces, but it is not established whether sIgA alone can prevent disease. We report here a strategy for identifying the antigen specificities of monoclonal sIgA antibodies that are capable of providing such protection. IgA hybridomas were generated from Peyer's patch lymphocytes after oral immunization with V. cholerae Ogawa 395. A clone was selected that produced dimeric monoclonal IgA antibodies directed against an Ogawa-specific lipopolysaccharide carbohydrate antigen exposed on the bacterial surface. Hybridoma cells were used to produce subcutaneous "backpack" tumors in syngeneic mice, resulting in secretion of monoclonal sIgA onto mucosal surfaces. Neonatal mice bearing anti-lipopolysaccharide hybridoma backpack tumors were specifically protected against oral challenge with 100 50% lethal doses of virulent Ogawa 395 organisms. Thus, the IgA hybridoma backpack tumor method identifies protective epitopes in the mucosal system and demonstrates that a single monoclonal sIgA can be sufficient to protect against intestinal disease.

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Crossref · 10.1128/iai.59.3.977-982.1991

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Metadata

Authors
Winner, L., Mack, J., Weltzin, R., Mekalanos, J. J., Kraehenbuhl, J. P., & Neutra, M. R.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1991-03
Volume
59
Issue
3
Pages
977-982
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.59.3.977-982.1991
OpenAlex
W1935780090
Cited by
253
References
16
FWCI
11.75
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. https://app.cochat.ai/papers/10.1128/iai.59.3.977-982.1991
The paper
Winner, L., Mack, J., Weltzin, R., Mekalanos, J. J., Kraehenbuhl, J. P., & Neutra, M. R. (1991). New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infection and Immunity. https://doi.org/10.1128/iai.59.3.977-982.1991

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.