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Serological Diagnosis of Tropical Canine Pancytopenia by Indirect Immunofluorescence
Open accessAbstract
An indirect fluorescent-antibody test for detection and titration of antibodies to Ehrlichia canis , the causative agent of tropical canine pancytopenia, has been described. The organism propagated by an in vitro technique in canine blood monocytes served as an antigen in the test. The specificity of the test was revealed by absence of cross-reactivity between the antigen and sera from dogs infected with various common pathogens and specific sera against eight rickettsial species. The accuracy of the test was ascertained by isolation of the organism from reactor dogs located in and outside the United States. Histopathological examination of nine reactor dogs revealed plasmacytosis of meninges and kidneys in eight of them.
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Citations
Cited by
Human Infection with Ehrlichia canis, a Leukocytic Rickettsia
Maeda, K., Markowitz, N., Hawley, R. C., Ristic, M., Cox, D., & McDade, J. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704023161406 · Cited by 493
Self-citationThe tribe Ehrlichieae and ehrlichial diseases
Rikihisa, Y. (1991) · Clinical Microbiology Reviews · doi:10.1128/cmr.4.3.286 · Cited by 451
Metadata
- Authors
- Ristic, M., Huxsoll, D. L., Weisiger, R. M., Hildebrandt, P. K., & Nyindo, M. B. A.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1972-09
- Volume
- 6
- Issue
- 3
- Pages
- 226-231
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1834999588
- Cited by
- 169
- References
- 0
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Serological Diagnosis of Tropical Canine Pancytopenia by Indirect Immunofluorescence. https://app.cochat.ai/papers/10.1128/iai.6.3.226-231.1972
- The paper
- Ristic, M., Huxsoll, D. L., Weisiger, R. M., Hildebrandt, P. K., & Nyindo, M. B. A. (1972). Serological Diagnosis of Tropical Canine Pancytopenia by Indirect Immunofluorescence. Infection and Immunity. https://doi.org/10.1128/iai.6.3.226-231.1972
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