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Cited by 451

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

The tribe Ehrlichieae and ehrlichial diseases

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Rikihisa, Y·1991·Clinical Microbiology Reviews

Abstract

The tribe Ehrlichieae consists of gram-negative minute cocci that are obligate intracellular parasites classified in the family Rickettsiaceae. Although ehrlichial organisms have been observed in leukocytes for many years, only a few species have been cultured in quantities sufficient for biochemical and molecular analyses. Recents studies on 16S-rRNA sequence analysis and energy metabolism showed that the genus Ehrlichia is closely related to the genus Rickettsia. There is, however, no antigenic cross-reactivity between these genera. Ehrlichial organisms cause a disease called "ehrlichiosis," a noncontagious infectious disease known to be transmitted by a tick in several cases and by a fluke in one case. Ehrlichia spp. infect dogs, ruminants, horses, and humans. Recently, two new ehrlichial diseases, Potomac horse fever and human ehrlichiosis, were discovered in the United States. The etiologic agent of Potomac horse fever, Ehrlichia risticii, is closely related to the known human pathogen Ehrlichia sennetsu. The etiologic agent of human ehrlichiosis is related to Ehrlichia canis, a canine pathogen. In contrast to the genus Rickettsia, members of the tribe Ehrlichieae reside primarily in the cytoplasmic vacuoles of monocytes or granulocytes and cause hematologic abnormalities, lymphadenopathy, and other pathologic changes in the host. However, the actual mechanisms whereby Ehrlichia spp. infect leukocytes, multiply in them, and produce various forms of systemic disease have not been defined. Depending on the ehrlichial species involved, serologic or direct microscopic observation of stained blood smears is currently used to diagnose ehrlichial disease.

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Metadata

Authors
Rikihisa, Y.
Venue
Clinical Microbiology Reviews
Published
1991-07
Volume
4
Issue
3
Pages
286-308
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2122064356
Cited by
451
References
29
FWCI
11.61
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The tribe Ehrlichieae and ehrlichial diseases. https://app.cochat.ai/papers/10.1128/cmr.4.3.286
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Rikihisa, Y. (1991). The tribe Ehrlichieae and ehrlichial diseases. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.4.3.286

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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