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Mouse neutrophils lack defensins
Open accessAbstract
Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.
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Citations
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Mammalian defensins in the antimicrobial immune response
Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,203
Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., Zasloff, M., & Wilson, J. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81895-4 · Cited by 1,080
Mammalian defensins in immunity: more than just microbicidal
Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696
Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Metadata
- Authors
- Eisenhauer, P. B., & Lehrer, R. I.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1992-08
- Volume
- 60
- Issue
- 8
- Pages
- 3446-3447
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1902412925
- Cited by
- 226
- References
- 0
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Eisenhauer, P. B., & Lehrer, R. I. (1992). Mouse neutrophils lack defensins. Infection and Immunity. https://doi.org/10.1128/iai.60.8.3446-3447.1992
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
