The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis
Open accessAbstract
The importance of a collagen-binding adhesin in the pathogenesis of septic arthritis has been examined by comparing the virulence of two sets of Staphylococcus aureus mutants in an animal model. Collagen adhesin-negative mutant PH100 was constructed by replacing the chromosomal collagen adhesin gene (cna) in a clinical strain, Phillips, with an inactivated copy of the gene. Collagen adhesin-positive mutant S. aureus CYL574 was generated by introducing the cna gene into CYL316, a strain that normally lacks the cna gene. Biochemical, immunological, and functional analyses of the generated mutants and their respective parent strains showed that binding of 125I-labeled collagen, expression of an immunoreactive collagen adhesin, and bacterial adherence to cartilage were directly correlated with the presence of a functional cna gene. Greater than 70% of the mice injected with the Cna+ strains developed clinical signs of arthritis, whereas less than 27% of the animals injected with Cna- strains showed symptoms of disease. Furthermore, mice injected with the Cna+ strain Phillips had remarkably elevated levels of immunoglobulin G1 and interleukin-6 compared with mice injected with the Cna- mutant PH100. Taken together, these results demonstrate that collagen adhesin plays an important role in the pathogenesis of septic arthritis induced by S. aureus.
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Cites
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I nvasion of D entinal T ubules by O ral B acteria
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Metadata
- Authors
- Patti, J. M., Bremell, T., Krajewska-Pietrasik, D., Abdelnour, A., Tarkowski, A., Rydén, C., & Höök, M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1994-01
- Volume
- 62
- Issue
- 1
- Pages
- 152-161
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2134254174
- Cited by
- 357
- References
- 17
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Patti, J. M., Bremell, T., Krajewska-Pietrasik, D., Abdelnour, A., Tarkowski, A., Rydén, C., & Höök, M. (1994). The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis. Infection and Immunity. https://doi.org/10.1128/iai.62.1.152-161.1994
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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