The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes
Open accessAbstract
Helicobacterpylori possesses two flagellin molecules, MA, the major species, and FlaB, which is expressed in minor amounts. This study sought to determine if one or both flagellin species are necessary for colonization or persistence by H. pylon. Thirty-six gnotobiotic piglets from six litters were given one of four isogenic strains of H. pylon orally. The bacterial strains used were strain N6, the wild type, which produced both FlaA and FlaB and was fully motile; N6flaB::km, which produced FlaA but not FlaB and was weakly motile; N6flaA::km, which expressed FlaB but not FlaA and was nonmotile; and N6flaA::cat/flaB::km, which produced neither flagellin and was nonmotile. Strain N6 colonized all piglets and persisted for 2, 4, and 10 days after inoculation. Both N6flaA::km and N6flaB::km colonized for 2 and 4 but not 10 days, and colonization was weak. N6flaA::cat/flaB:: km colonized for 2 days but did not persist for 4 or 10 days after inoculation. These findings demonstrate that both flagellin species are necessary for full colonization by H. pylon. Colonization for up to 4 days is possible in the absence of either flagellin species but not both.
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Cites
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Helicobacter pylori Infection and the Risk of Gastric Carcinoma
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Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens
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Self-citationTummuru, M. K., Cover, T. L., & Blaser, M. J. (1993) · Infection and Immunity · doi:10.1128/iai.61.5.1799-1809.1993 · Cited by 658
Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori
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Self-citationMotility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori
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Cited by
The role of motility as a virulence factor in bacteria
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Self-citationHelicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis
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The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells
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Regulation cascade of flagellar expression in Gram-negative bacteria
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Iron deficiency accelerates Helicobacter pylori–induced carcinogenesis in rodents and humans
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Metadata
- Authors
- Eaton, K. A., Suerbaum, S., Josenhans, C., & Krakowka, S.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1996-07
- Volume
- 64
- Issue
- 7
- Pages
- 2445-2448
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2126952238
- Cited by
- 355
- References
- 20
- FWCI
- 18.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Eaton, K. A., Suerbaum, S., Josenhans, C., & Krakowka, S. (1996). Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes. Infection and Immunity. https://doi.org/10.1128/iai.64.7.2445-2448.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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