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Cited by 5,509Helicobacter pylori-related gastroenterology studiesSalmonella and Campylobacter epidemiologyGut microbiota and health

The DOI matches its Crossref record.

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

Marshall, BarryJ, Warren, J.Robin·1984·The Lancet
DOI 10.1016/s0140-6736(84)91816-6
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Abstract

Biopsy specimens were taken from intact areas of antral mucosa in 100 consecutive consenting patients presenting for gastroscopy. Spiral or curved bacilli were demonstrated in specimens from 58 patients. Bacilli cultured from 11 of these biopsies were gram-negative, flagellate, and microaerophilic and appeared to be a new species related to the genus Campylobacter. The bacteria were present in almost all patients with active chronic gastritis, duodenal ulcer, or gastric ulcer and thus may be an important factor in the aetiology of these diseases.

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Crossref · 10.1016/s0140-6736(84)91816-6

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  • Peptic ulcers, in many instances, are secondary to a chronic infection of the upper gastrointestinal tract by Helicobacter pylori.

    “History gives us a somewhat parallel case in the determination that peptic ulcers, in many instances, are secondary to a chronic infection of the upper gastrointestinal tract by a bacterium called Helicobacter pylori.”

    From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [10]

  • In Marshall's study of 100 dyspepsia cases undergoing endoscopy, 87% of ulcer-caused dyspepsia cases had H. pylori present, whereas only 50% of non-ulcer cases had H. pylori.

    “In the dyspepsia cases caused by ulcer, 87% had H. pylori present, but in other non-ulcer cases only 50% had H. pylori [10].”

    From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [10]

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 25

  1. Doenges, 1938, Spirochaetes in gastric glands of macacus rhesus and humans without definite history of related disease, Proc Soc Exp Biol Med, 38, 536, 10.3181/00379727-38-9924P · DOI
  2. Fung, 1979, Endoscopic, histological and ultrustructural correlations in chronic gastritis, Am J Gasiroenterol, 71, 269
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  4. Palmer, 1954, Investigation of the gastric Spirochaetes of the human, Gastroenterology, 27, 218, 10.1016/S0016-5085(19)36173-6 · DOI
  5. Steer, 1975, Mucosal changes in gastric ulceration and their response to carbenoxolone sodium, Gut, 16, 590, 10.1136/gut.16.8.590 · DOI
  6. Warren, 1983, Unidentified curved bacilli on gastric epithelium in active chronic gastritis, Lancet, i, 1273
  7. Whitehead, 1972, The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens, J Clin Pathol, 25, 1, 10.1136/jcp.25.1.1 · DOI
  8. Pead, 1979, Electron microscopy of Campylobacter jejuni, J Med Microbiol, 12, 383, 10.1099/00222615-12-3-383 · DOI
  9. Crean, 1982, Ulcer-like dyspepsia, Scand J Gastroenterol, 17, 9
  10. Greenlaw, 1980, Gastroduodenitis: a broader concept of peptic ulcer disease, Dig Dis Set, 25, 660, 10.1007/BF01308325 · DOI
  11. Giannela, 1972, Gastric acid barrier to ingested microorganisms in man: Studies in vivo and in vitro, Gut, 13, 251, 10.1136/gut.13.4.251 · DOI
  12. Blaser, 1981, Campylobacter enteritis, N Engl J Med, 305, 1444, 10.1056/NEJM198112103052404 · DOI
  13. MacDonald, 1973, Correlation of mucosal histology and aspirin intake in chronic gastric ulcer, Gastroenterology, 65, 381, 10.1016/S0016-5085(19)33068-9 · DOI
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  15. Goldner, 1976, Relationship of bile in the stomach to gastritis, Gastrointest Endosc, 22, 197, 10.1016/S0016-5107(76)73752-0 · DOI
  16. Gilmore, 1978, Effect of short and long term cimetidine on histological duodenitis and gastritis, Gut, 19, 981
  17. Mclntrye, 1982, Effect of cimetidine on chronic gastritis in gastric ulcer patients, Aust NZ J Med, 12, 106
  18. Schrager, 1967, The antrum in patients with duodenal and gastric ulcers, Gut, 8, 497, 10.1136/gut.8.5.497 · DOI
  19. Allen, 1980, Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection, Gut, 21, 249, 10.1136/gut.21.3.249 · DOI
  20. Draser, 1969, Studies on the intestinal flora I: The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons, Gastroenterology, 56, 71
  21. Enander, 1982, The aerobic and anaerobic flora of the gastric remnant more than 15 years after Billroth II resection, Scand J Gastroenterol, 17, 715, 10.3109/00365528209181084 · DOI
  22. Mackay, 1966, Chronic gastritis and gastric ulcer, Gut, 7, 228, 10.1136/gut.7.3.228 · DOI
  23. Rollason, 1984, Spiral organisms in endoscopic biopsies of the human stomach, J Clin Pathol, 37, 23, 10.1136/jcp.37.1.23 · DOI
  24. Martin, 1980, Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium di-citrato bismuthate, Lancet, i, 7
  25. B. Marshall, I. Hislop, R. Glancy, J. Armstrong, Histological improvement of active chronic gastritis in patients treated with De-Nol, Aust NZ J Med ((in press) (abstr)).

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Metadata

Authors
Marshall, B., & Warren, J. R.
Affiliations
Royal Perth Hospital (AU)
Venue
The Lancet
Publisher
Elsevier BV
Published
1984-06
Volume
323
Issue
8390
Pages
1311-1315
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(84)91816-6
OpenAlex
W2143107875
Cited by
5,509
References
0
Citations by year
2026: 89 · 2025: 136 · 2024: 178 · 2023: 161 · 2022: 154 · 2021: 182 · 2020: 173 · 2019: 168 · 2018: 153 · 2017: 173 · 2016: 195 · 2015: 198 · 2014: 237 · 2013: 181 · 2012: 165
FWCI
75.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Campylobacter, chronic gastritis, peptic ulcer, duodenal ulcer, gastric ulcer, bacterial etiology, gastric biopsy
MeSH terms
Adult, Aged, Bacteria, Campylobacter, Female, Gastric Mucosa, Gastritis, Humans, Male, Middle Aged, Peptic Ulcer

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