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Cited by 1,483Inflammatory Bowel DiseaseGut microbiota and healthT-cell and B-cell Immunology

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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Sellon, Rance K., Tonkonogy, Susan, Schultz, Michael, Dieleman, Levinus A., Grenther, Wetonia, Balish, Ed, Rennick, Donna M., Sartor, R. Balfour·1998·Infection and Immunity
DOI 10.1128/iai.66.11.5224-5231.1998PMC PMC108652
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Abstract

Mice with targeted deletion of the gene for interleukin-10 (IL-10) spontaneously develop enterocolitis when maintained in conventional conditions but develop only colitis when kept in specific-pathogen-free (SPF) environments. This study tested the hypothesis that enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice. IL-10-deficient mice were maintained in either SPF conditions or germfree conditions or were populated with bacteria known to cause colitis in other rodent models. IL-10-deficient mice kept in SPF conditions developed colitis in all segments of the colon (cecum and proximal and distal colon). These mice exhibited immune system activation as evidenced by increased expression of CD44 on CD4 + T cells; increased mesenteric lymph node cell numbers; and increased production of immunoglobulin A (IgA), IgG1, and IL-12 p40 from colon fragment cultures. Mice populated with bacterial strains, including Bacteroides vulgatus , known to induce colitis in other rodent models had minimal colitis. Germfree IL-10-deficient mice had no evidence of colitis or immune system activation. We conclude therefore that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.

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Crossref · 10.1128/iai.66.11.5224-5231.1998

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  1. MacDonald T. T. Carter P. B. Contact sensitivity in germfree mice.J. Reticuloendothel. Soc.241978287293

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Metadata

Authors
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B.
Affiliations
  • <!--label omitted: 1-->Department of Companion Animal and Special Species1 and
  • North Carolina State University (US)
  • University of North Carolina at Chapel Hill (US)
  • <!--label omitted: 4-->Departments of Surgery and Microbiology, University of Wisconsin, Madison, Wisconsin,4 and
  • <!--label omitted: 5-->Department of Immunology, DNAX Corporation, Palo Alto, California5
ORCID
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1998-11
Volume
66
Issue
11
Pages
5224-5231
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.66.11.5224-5231.1998
PMC
PMC108652
OpenAlex
W2165528446
Cited by
1,483
References
56
Citations by year
2026: 24 · 2025: 26 · 2024: 37 · 2023: 34 · 2022: 48 · 2021: 48 · 2020: 42 · 2019: 71 · 2018: 61 · 2017: 55 · 2016: 61 · 2015: 73 · 2014: 89 · 2013: 77 · 2012: 70
FWCI
15.03
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Infection and Immunity (publishedVersion)
  • PubMed Central (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
interleukin-10 deficiency, spontaneous colitis, enteric bacteria, germ-free mice, specific pathogen-free mice, immune activation, Bacteroides vulgatus, CD4+ T cells, CD44, mesenteric lymph nodes, immunoglobulin A, IL-12p40
MeSH terms
Animals, Colitis, Disease Models, Animal, Enterobacteriaceae, Immune System, Inflammation, Intestine, Large, Lymphocyte Activation, Mice, Inbred C57BL, Specific Pathogen-Free Organisms, Interleukin-10, Mice, Knockout, Mice

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