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Secretory Phospholipase A 2 Is the Principal Bactericide for Staphylococci and Other Gram-Positive Bacteria in Human Tears
Open accessAbstract
We examined human tears for molecules that killed gram-positive bacteria. The principal mediator of bactericidal activity against staphylococci proved to be a calcium-dependent enzyme, secretory phospholipase A 2 . Whereas the concentration of secretory phospholipase A 2 in the normal tear film exceeded 30 μg/ml, only 1.1 ng (<0.1 nM) of the enzyme per ml sufficed to kill Listeria monocytogenes and 15 to 80 ng/ml killed Staphylococcus aureus . Despite its efficacy against gram-positive bacteria, secretory phospholipase A 2 lacked bactericidal activity against gram-negative organisms ( Escherichia coli , Salmonella typhimurium , and Pseudomonas aeruginosa ) when tested in the ionic environment of tears. Given the presence of secretory phospholipase A 2 in tears, intestinal secretions, and leukocytes, this enzyme may play a substantial role in innate mucosal and systemic bactericidal defenses against gram-positive bacteria.
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Cited by
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Dennis, E. A., Cao, J., Hsu, Y.-H., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,203
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Nauseef, W. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00550.x · Cited by 756
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Metadata
- Authors
- Qu, X.-D., & Lehrer, R. I.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-06
- Volume
- 66
- Issue
- 6
- Pages
- 2791-2797
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2144472726
- Cited by
- 252
- References
- 0
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Qu, X.-D., & Lehrer, R. I. (1998). Secretory Phospholipase A 2 Is the Principal Bactericide for Staphylococci and Other Gram-Positive Bacteria in Human Tears. Infection and Immunity. https://doi.org/10.1128/iai.66.6.2791-2797.1998
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