The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Alternative mechanisms of action of cationic antimicrobial peptides on bacteria
Abstract
Cationic antimicrobial peptides are a novel type of antibiotic offering much potential in the treatment of microbial-related diseases. They offer many advantages for commercial development, including a broad spectrum of action and modest size. However, despite the identification or synthetic production of thousands of such peptides, the mode of action remains elusive, except for a few examples. While the dogma for the mechanism of action of antimicrobial peptides against bacteria is believed to be through pore formation or membrane barrier disruption, some peptides clearly act differently and other intracellular target sites have been identified. This article presents an updated review of how cationic antimicrobial peptides are able to affect bacterial killing, with a focus on internal targets.
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Citations
Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
Hancock, R. E. W., & Sahl, H.-G. (2006) · Nature Biotechnology · doi:10.1038/nbt1267 · Cited by 4,208
Self-citationJenssen, H., Hamill, P., & Hancock, R. E. W. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00056-05 · Cited by 2,518
Self-citationHancock, R. E. W., & Chapple, D. S. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.6.1317 · Cited by 1,190
Self-citationHancock, R. E. (1997) · The Lancet · doi:10.1016/s0140-6736(97)80051-7 · Cited by 1,096
Self-citationThe co-evolution of host cationic antimicrobial peptides and microbial resistance
Peschel, A., & Sahl, H.-G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1441 · Cited by 1,062
The relationship between peptide structure and antibacterial activity
Powers, J.-P. S., & Hancock, R. E. W. (2003) · Peptides · doi:10.1016/j.peptides.2003.08.023 · Cited by 948
Self-citationPark, C. B., Kim, H. S., & Kim, S. C. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8159 · Cited by 896
Cationic host defense (antimicrobial) peptides
Brown, K. L., & Hancock, R. E. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.004 · Cited by 839
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Cited by
Reassessing the Host Defense Peptide Landscape
Haney, E. F., Straus, S. K., & Hancock, R. E. W. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00043 · Cited by 359
Self-citationAntimicrobial Peptides: An Update on Classifications and Databases
Bin Hafeez, A., Jiang, X., Bergen, P. J., & Zhu, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111691 · Cited by 341
Natural roles of antimicrobial peptides in microbes, plants and animals
Maróti, G., Kereszt, A., Kondorosi, É., & Mergaert, P. (2011) · Research in Microbiology · doi:10.1016/j.resmic.2011.02.005 · Cited by 298
Colistin: new lessons on an old antibiotic
Yahav, D., Farbman, L., Leibovici, L., & Paul, M. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03734.x · Cited by 259
Antimicrobial peptides: promising compounds against pathogenic microorganisms
Cruz, J., Ortiz, C., Guzmán, F., Fernández-Lafuente, R., & Torres, R. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140217110155 · Cited by 166
Metadata
- Authors
- Hale, J. D., & Hancock, R. E.
- Venue
- Expert Review of Anti-infective Therapy
- Publisher
- Informa UK Limited
- Published
- 2007-12
- Volume
- 5
- Issue
- 6
- Pages
- 951-959
- ISSN
- 1478-7210 (ISSN-L)
- 1744-8336
- OpenAlex
- W2077491098
- Cited by
- 549
- References
- 64
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
