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Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage of Streptococcus pneumoniae
Open accessAbstract
Acquisition of pneumococci is generally from carriers rather than from infected individuals. Therefore, to induce herd immunity against Streptococcus pneumoniae it will be necessary to elicit protection against carriage. Capsular polysaccharide-protein conjugates, PspA, and PsaA are known to elicit some protection against nasopharyngeal carriage of pneumococci but do not always completely eliminate carriage. In this study, we observed that PsaA elicited better protection than did PspA against carriage. Pneumolysin elicited no protection against carriage. Immunization with a mixture of PsaA and PspA elicited the best protection against carriage. These results indicate that PspA and PsaA may be useful for the elicitation of herd immunity in humans. As PspA and pneumolysin are known to elicit immunity to bacteremia and pneumonia, their inclusion in a mucosal vaccine may enable such a vaccine to prevent invasive disease as well as carriage.
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Dintilhac, A., Alloing, G., Granadel, C., & Claverys, J. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.5111879.x · Cited by 380
Berry, A. M., & Paton, J. C. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5255-5262.1996 · Cited by 261
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Cited by
Streptococcus pneumoniae colonisation: the key to pneumococcal disease
Bogaert, D., de Groot, R., & Hermans, P. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)00938-7 · Cited by 1,929
Garmory, H. S., & Titball, R. W. (2004) · Infection and Immunity · doi:10.1128/iai.72.12.6757-6763.2004 · Cited by 293
The Immune Response to Pneumococcal Proteins during Experimental Human Carriage
McCool, T. L., Cate, T. R., Moy, G., & Weiser, J. N. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011576 · Cited by 270
Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization
McCool, T. L., & Weiser, J. N. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5807-5813.2004 · Cited by 153
Strand, T. A., Hollingshead, S. K., Julshamn, K., Briles, D. E., Blomberg, B., & Sommerfelt, H. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.2009-2013.2003 · Cited by 44
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Metadata
- Authors
- Briles, D. E., Ades, E., Paton, J. C., Sampson, J. S., Carlone, G. M., Huebner, R. C., Virolainen, A., Swiatlo, E., & Hollingshead, S. K.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2000-02
- Volume
- 68
- Issue
- 2
- Pages
- 796-800
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2165861950
- Cited by
- 308
- References
- 2
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Briles, D. E., Ades, E., Paton, J. C., Sampson, J. S., Carlone, G. M., Huebner, R. C., Virolainen, A., Swiatlo, E., & Hollingshead, S. K. (2000). Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage of Streptococcus pneumoniae. Infection and Immunity. https://doi.org/10.1128/iai.68.2.796-800.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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