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Fate of Mycobacterium tuberculosis within Murine Dendritic Cells
Open accessAbstract
The interaction of microbes with dendritic cells (DCs) is likely to have an enormous impact on the initiation of the immune response against a pathogen. In this study, we compared the interaction of Mycobacterium tuberculosis with murine bone marrow-derived DCs and macrophages (Mφ) in vitro.M. tuberculosis grew equally well within nonactivated DCs and Mφ. Activation of DCs and Mφ with gamma interferon and lipopolysaccharide inhibited the growth of the intracellular bacteria in a nitric oxide synthase-dependent fashion. However, while this activation enabled Mφ to kill the intracellular bacteria, the M. tuberculosis bacilli within activated DCs were not killed. Thus, DCs could restrict the growth of the intracellular mycobacteria but were less efficient than Mφ at eliminating the infection. These results may have implications for priming immune responses to M. tuberculosis. In addition, they suggest that DCs may serve as a reservoir for M. tuberculosis in tissues, including the lymph nodes and lungs.
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Cited by
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
Smith, I. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.463-496.2003 · Cited by 1,154
North, R. J., & Jung, Y.-J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104635 · Cited by 677
The role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O'Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472
Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection
Tufariello, J. M., Chan, J., & Flynn, J. L. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00741-2 · Cited by 403
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Metadata
- Authors
- Bodnar, K. A., Serbina, N. V., & Flynn, J. L.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-02
- Volume
- 69
- Issue
- 2
- Pages
- 800-809
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2130615964
- Cited by
- 213
- References
- 0
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- green
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