The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages
Open accessAbstract
Lipopolysaccharide (LPS) derived from the periodontal pathogen Porphyromonas gingivalis has been reported to differ structurally and functionally from enterobacterial LPS. These studies demonstrate that in contrast to protein-free enterobacterial LPS, a similarly purified preparation of P. gingivalis LPS exhibited potent Toll-like receptor 2 (TLR2), rather than TLR4, agonist activity to elicit gene expression and cytokine secretion in murine macrophages and transfectants. More importantly, TLR2 stimulation by this P. gingivalis LPS preparation resulted in differential expression of a panel of genes that are normally induced in murine macrophages by Escherichia coli LPS. These data suggest that (i)P. gingivalis LPS does not signal through TLR4 and (ii) signaling through TLR2 and through TLR4 differs quantitatively and qualitatively. Our data support the hypothesis that the shared signaling pathways elicited by TLR2 and by TLR4 agonists must diverge in order to account for the distinct patterns of inflammatory gene expression.
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Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
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Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)
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Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
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Self-citationImmunity to Intracellular Bacteria
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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products
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Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
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Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
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Self-citation
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Metadata
- Authors
- Hirschfeld, M., Weis, J. J., Toshchakov, V., Salkowski, C. A., Cody, M. J., Ward, D. C., Qureshi, N., Michalek, S. M., & Vogel, S. N.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-03
- Volume
- 69
- Issue
- 3
- Pages
- 1477-1482
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2156445477
- Cited by
- 655
- References
- 37
- FWCI
- 19.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages. https://app.cochat.ai/papers/10.1128/iai.69.3.1477-1482.2001
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- Hirschfeld, M., Weis, J. J., Toshchakov, V., Salkowski, C. A., Cody, M. J., Ward, D. C., Qureshi, N., Michalek, S. M., & Vogel, S. N. (2001). Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages. Infection and Immunity. https://doi.org/10.1128/iai.69.3.1477-1482.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
