The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Anaerobic Conditions Induce Expression of Polysaccharide Intercellular Adhesin in Staphylococcus aureus and Staphylococcus epidermidis
Open accessAbstract
Products of the intercellular adhesion ( ica ) operon in Staphylococcus aureus and Staphylococcus epidermidis synthesize a linear β-1,6-linked glucosaminylglycan. This extracellular polysaccharide mediates bacterial cell-cell adhesion and is required for biofilm formation, which is thought to increase the virulence of both pathogens in association with prosthetic biomedical implants. The environmental signal(s) that triggers ica gene product and polysaccharide expression is unknown. Here we demonstrate that anaerobic in vitro growth conditions lead to increased polysaccharide expression in both S. aureus and S. epidermidis , although the regulation is less stringent in S. epidermidis . Anaerobiosis also dramatically stimulates ica -specific mRNA expression in ica - and polysaccharide - positive strains of both S. aureus and S. epidermidis. These data suggest a mechanism whereby ica gene expression and polysaccharide production may act as a virulence factor in an anaerobic environment in vivo.
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Citations
Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Cited by
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiss, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213870 · Cited by 932
Self-citationHobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
“…Geoghegan et al. 2013), clumping factor B (ClfB) (Abraham and Jefferson 2012), serine-aspartate repeat protein C (SdrC) (Barbu et al. 2014), S. aureus surface protein C (SasC) (Schroeder et al. 2009), S. aureus surface protein G (SasG) (Geoghegan et al. 2010) and protein A (Merino et al. 2009).”
BackgroundThe antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
de Breij, A., Riool, M., Cordfunke, R. A., Malanovic, N., de Boer, L., Koning, R. I., Ravensbergen, E., Franken, M., van der Heijde, T., Boekema, B. K., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan4044 · Cited by 555
Methicillin resistance and the biofilm phenotype in Staphylococcus aureus
McCarthy, H., Rudkin, J. K., Black, N. S., Gallagher, L., O'Neill, E., & O'Gara, J. P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00001 · Cited by 426
Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections
Linz, M. S., Mattappallil, A., Finkel, D., & Parker, D. (2023) · Antibiotics · doi:10.3390/antibiotics12030557 · Cited by 293
Metadata
- Authors
- Cramton, S. E., Ulrich, M., Götz, F., & Döring, G.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-06
- Volume
- 69
- Issue
- 6
- Pages
- 4079-4085
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2131237419
- Cited by
- 345
- References
- 1
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Cramton, S. E., Ulrich, M., Götz, F., & Döring, G. (2001). Anaerobic Conditions Induce Expression of Polysaccharide Intercellular Adhesin in Staphylococcus aureus and Staphylococcus epidermidis. Infection and Immunity. https://doi.org/10.1128/iai.69.6.4079-4085.2001
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