The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
CdtA, CdtB, and CdtC Form a Tripartite Complex That Is Required for Cytolethal Distending Toxin Activity
Open accessAbstract
Campylobacter jejuni encodes a cytolethal distending toxin (CDT) that causes cells to arrest in the G 2/M transition phase of the cell cycle. Highly related toxins are also produced by other important bacterial pathogens. CDT activity requires the function of three genes:cdtA, cdtB, and cdtC. Recent studies have established that CdtB is the active subunit of CDT, exerting its effect as a nuclease that damages the DNA and triggers cell cycle arrest. Microinjection of CdtB into target cells led to G 2/M arrest and cytoplasmic distention, in a manner indistinguishable from that caused by CDT treatment. Despite this progress, nothing is known about the composition of the CDT holotoxin or the function of CdtA and CdtC. We show here that, when applied individually, purified CdtA, CdtB, or CdtC does not exhibit toxic activity. In contrast, CdtA, CdtB, and CdtC when combined, interact with one another to form an active tripartite holotoxin that exhibits full cellular toxicity. CdtA has a domain that shares similarity with the B chain of ricin-related toxins. We therefore proposed that CDT is a tripartite toxin composed of CdtB as the enzymatically active subunit and of CdtA and CdtC as the heterodimeric B subunit required for the delivery of CdtB.
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Cites
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A Bacterial Toxin That Controls Cell Cycle Progression as a Deoxyribonuclease I-Like Protein
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Self-citationAcute Enteritis Due to Related Vibrio: First Positive Stool Cultures
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Cited by
Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome
Barrett, M., Hand, C. K., Shanahan, F., Murphy, T., & O’Toole, P. W. (2020) · Trends in Cancer · doi:10.1016/j.trecan.2020.01.019 · Cited by 108
Metadata
- Authors
- Lara-Tejero, M., & Galán, J. E.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-07
- Volume
- 69
- Issue
- 7
- Pages
- 4358-4365
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2135906691
- Cited by
- 357
- References
- 29
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- green
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