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Cited by 289

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice

Open access
Eruslanov, Evgenyi B., Lyadova, Irina V., Kondratieva, Tatiana K., Majorov, Konstantin B., Scheglov, Ilya V., Orlova, Marianna O., Apt, Alexander S.·2005·Infection and Immunity
DOI 10.1128/iai.73.3.1744-1753.2005
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Abstract

The role of neutrophils in tuberculosis (TB) resistance and pathology is poorly understood. Neutrophil reactions are meant to target the offending pathogen but may lead to destruction of the host lung tissue, making the defending cells an enemy. Here, we show that mice of the I/St strain which are genetically susceptible to TB show an unusually high and prolonged neutrophil accumulation in their lungs after intratracheal infection. Compared to neutrophils from more resistant A/Sn mice, I/St neutrophils display an increased mobility and tissue influx, prolonged lifespan, low expression of the CD95 (Fas) apoptotic receptor, relative resistance to apoptosis, and an increased phagocytic capacity for mycobacteria. Segregation genetic analysis in (I/St × A/Sn)F 2 hybrids indicates that the alleles of I/St origin at the chromosome 3 and 17 quantitative trait loci which are involved in the control of TB severity also determine a high level of neutrophil influx. These features, along with the poor ability of neutrophils to restrict mycobacterial growth compared to that of lung macrophages, indicate that the prevalence of neutrophils in TB inflammation contributes to the development of pathology, rather than protection of the host, and that neutrophils may play the role of a “Trojan horse” for mycobacteria.

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Crossref · 10.1128/iai.73.3.1744-1753.2005

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Metadata

Authors
Eruslanov, E. B., Lyadova, I. V., Kondratieva, T. K., Majorov, K. B., Scheglov, I. V., Orlova, M. O., & Apt, A. S.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
2005-03
Volume
73
Issue
3
Pages
1744-1753
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.73.3.1744-1753.2005
OpenAlex
W2105446471
Cited by
289
References
46
FWCI
4.40
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice. https://app.cochat.ai/papers/10.1128/iai.73.3.1744-1753.2005
The paper
Eruslanov, E. B., Lyadova, I. V., Kondratieva, T. K., Majorov, K. B., Scheglov, I. V., Orlova, M. O., & Apt, A. S. (2005). Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice. Infection and Immunity. https://doi.org/10.1128/iai.73.3.1744-1753.2005

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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