The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model
Open accessAbstract
Innate immunity signaling mechanisms during vertebrate embryogenesis are largely unknown. To study Toll-like receptor (TLR) signaling function in the zebrafish embryo model, we designed an experimental setup for antisense morpholino knockdown under conditions of bacterial infection. Clearance of Salmonella enterica serovar Typhimurium Ra bacteria was significantly impaired after knockdown of myeloid differentiation factor 88 (MyD88), a common adaptor protein in TLR and interleukin-1 receptor signaling. Thereby, we demonstrate for the first time that the innate immune response of the developing embryo involves MyD88-dependent signaling, which further establishes the zebrafish embryo as a model for the study of vertebrate innate immunity.
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Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Herbomel, P., Thisse, B., & Thisse, C. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0393 · Cited by 574
The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis
Davidson, A. J., & Zon, L. I. (2004) · Oncogene · doi:10.1038/sj.onc.1207943 · Cited by 419
Cited by
Toll-like receptors — taking an evolutionary approach
Leulier, F., & Lemaitre, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2303 · Cited by 581
Stein, C., Caccamo, M., Laird, G., & Leptin, M. (2007) · Genome Biology · doi:10.1186/gb-2007-8-11-r251 · Cited by 374
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
Tobin, D. M., & Ramakrishnan, L. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01133.x · Cited by 343
Metadata
- Authors
- van der Sar, A. M., Stockhammer, O. W., van der Laan, C., Spaink, H. P., Bitter, W., & Meijer, A. H.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2006-04
- Volume
- 74
- Issue
- 4
- Pages
- 2436-2441
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2098485561
- Cited by
- 183
- References
- 4
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
