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Cited by 283

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Role of Pili in the Virulence of Neisseria gonorrhoeae

Open access
Punsalang, Amado P., Sawyer, William D.·1973·Infection and Immunity

Abstract

Gonococci of the colonial types that are associated with virulence, types 1 and 2, have pili that enable the bacteria both to attach in vitro to human epithelial cells and to resist phagocytosis by polymorphonuclear leukocytes. These piliated gonococci also agglutinate various mammalian and chicken erythrocytes. Gonococci of an avirulent colonial type, i.e., type 4, have no pili and neither attach to epithelial cells or erythrocytes nor resist phagocytosis. Like the type 4 bacteria, mechanically or enzymatically (trypsin) depiliated type 1 gonococci failed to attach to epithelial cells and erythrocytes and were susceptible to phagocytosis. Pili of types 1 and 2 gonococci were antigenically similar. Both type 1 gonococci and pili isolated from them induced in rabbits antibody that (i) precipitated gonococcal pili in immunodiffusion, (ii) reacted with piliated gonococci as tested by indirect immunofluorescent analysis, (iii) inhibited attachment of piliated gonococci to both human epithelial cells and erythrocytes, and (iv) opsonized piliated gonococci.

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Crossref · 10.1128/iai.8.2.255-263.1973

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Metadata

Authors
Punsalang, A. P., & Sawyer, W. D.
Venue
Infection and Immunity
Published
1973-08
Volume
8
Issue
2
Pages
255-263
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
OpenAlex
W1820746812
Cited by
283
References
16
FWCI
33.36
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Role of Pili in the Virulence of Neisseria gonorrhoeae. https://app.cochat.ai/papers/10.1128/iai.8.2.255-263.1973
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Punsalang, A. P., & Sawyer, W. D. (1973). Role of Pili in the Virulence of Neisseria gonorrhoeae. Infection and Immunity. https://doi.org/10.1128/iai.8.2.255-263.1973

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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