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Quorum-Sensing Regulation of the Biofilm Matrix Genes (pel) of Pseudomonas aeruginosa
Open accessAbstract
Quorum sensing (QS) has been previously shown to play an important role in the development of Pseudomonas aeruginosa biofilms (D. G. Davies et al., Science 280:295-298, 1998). Although QS regulation of swarming and DNA release has been shown to play important roles in biofilm development, regulation of genes directly involved in biosynthesis of biofilm matrix has not been described. Here, transcription of the pel operon, essential for the production of a glucose-rich matrix exopolysaccharide, is shown to be greatly reduced in lasI and rhlI mutants. Chemical complementation of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wild-type level and biofilm formation ability. These findings thus connect QS signaling and transcription of genes responsible for biofilm matrix biosynthesis.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Cited by
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,048
Bacterial polymers: biosynthesis, modifications and applications
Rehm, B. H. A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2354 · Cited by 899
Nadell, C. D., Xavier, J. B., & Foster, K. R. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00150.x · Cited by 667
Shrout, J. D., & Nerenberg, R. (2012) · Environmental Science & Technology · doi:10.1021/es203933h · Cited by 339
Hordenine: A Novel Quorum Sensing Inhibitor and Antibiofilm Agent against Pseudomonas aeruginosa
Zhou, J.-W., Luo, H.-Z., Jiang, H., Jian, T.-K., Chen, Z.-Q., & Jia, A.-Q. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05035 · Cited by 206
Metadata
- Authors
- Sakuragi, Y., & Kolter, R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2007-07-15
- Volume
- 189
- Issue
- 14
- Pages
- 5383-5386
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2135822024
- Cited by
- 347
- References
- 1
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
