The DOI matches its Crossref record.
SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression
Abstract
The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“SarA regulates biofilm formation through the agr-dependent pathway, binds to the agr promoter to stimulate transcription of RNAIII, and cascades and regulates downstream target genes [105,106].”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 23
- 10.1128/jb.178.15.4563-4570.1996 · DOI · Paper page
- 10.1128/JB.183.17.5171-5179.2001 · DOI · Paper page
- 10.1128/JB.180.23.6232-6241.1998 · doi:10.1128/jb.180.23.6232-6241.1998 · Paper page
- Cheung, A. L., A. S. Bayer, G. Zhang, H. Gresham, and Y.-Q. Xiong. 2004. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Microbiol. Lett. 1649 : 1-9.
- 10.1128/IAI.67.3.1331-1337.1999 · DOI
- 10.1128/IAI.73.7.4391-4394.2005 · doi:10.1128/iai.73.7.4391-4394.2005
- 10.1128/IAI.66.12.5988-5993.1998 · DOI
- Chien, C.-T., A. C. Manna, S. J. Projan, and A. L. Cheung. 1999. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J. Biol. Chem. 274 : 37169-37176. · DOI · Paper page
- 10.1128/JB.183.24.7341-7353.2001 · DOI · Paper page
- 10.1128/JB.183.6.1843-1852.2001 · DOI · Paper page
- Hong, M., M. Fuangthong, J. D. Helmann, and R. G. Brennan. 2005. Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. Mol. Cell 20 : 131-141. · DOI · Paper page
- Liu, Y., A. C. Manna, R. Li, W. E. Martin, A. L. Cheung, and G. Zhang. 2001. Crystal structure of the SarR protein from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 98 : 6877-6882. · DOI
- Liu, Y., A. C. Manna, C. H. Pan, I. A. Kriksunov, D. J. Thiel, A. L. Cheung, and G. Zhang. 2006. Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 103 : 2392-2397. · DOI
- 10.1056/NEJM199808203390806 · DOI · Paper page
- 10.1128/JB.180.15.3828-3836.1998 · DOI
- 10.1128/IAI.69.2.885-896.2001 · DOI
- 10.1128/JB.181.9.2846-2851.1999 · DOI
- Munson, G. P., and J. R. Scott. 2000. Rns, a virulence regulator within the AraC family, requires binding sites upstream and downstream of its own promoter to function as an activator. Mol. Microbiol. 36 : 1391-1402. · doi:10.1046/j.1365-2958.2000.01957.x
- Novick, R. P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48 : 1429-1449. · DOI · Paper page
- 10.1128/IAI.69.12.7858-7865.2001 · DOI
- Safo, M. K., T. P. Ko, F. N. Musayev, Q. Zhao, A. H. Wang, and G. L. Archer. 2006. Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62 : 320-324. · DOI
- 10.1128/JB.187.5.1833-1844.2005 · DOI
- Wolz, C., A. Steinhuber, P. Pohlmann-Dietze, Y. T. Chien, A. C. Manna, W. Van Wamel, and A. L. Cheung. 2000. Agr-independent regulation of fibronectin binding protein(s) by the regulatory locus sar in Staphylococcus aureus. Mol. Microbiol. 36 : 230-243. · DOI
Cited by
A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Peng, Q., Tang, X., Dong, W., Sun, N., & Yuan, W. (2022) · Antibiotics · doi:10.3390/antibiotics12010012 · Cited by 440
Metadata
- Authors
- Cheung, A. L., Nishina, K., & Manna, A. C.
- Affiliations
- Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755
- Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota 57069
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2008-03-15
- Volume
- 190
- Issue
- 6
- Pages
- 2239-2243
- ISSN
- 0021-9193
- 1098-5530
- Cited by
- 56
- References
- 0
- Language
- en
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression. https://app.cochat.ai/papers/10.1128/jb.01826-07
- The paper
- Cheung, A. L., Nishina, K., & Manna, A. C. (2008). SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression. Journal of Bacteriology. https://doi.org/10.1128/jb.01826-07
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.