Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 56

The DOI matches its Crossref record.

SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression

Cheung, Ambrose L., Nishina, Koren, Manna, Adhar C.·2008·Journal of Bacteriology

Abstract

The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/jb.01826-07

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 23

  1. 10.1128/jb.178.15.4563-4570.1996 · DOI · Paper page
  2. 10.1128/JB.183.17.5171-5179.2001 · DOI · Paper page
  3. 10.1128/JB.180.23.6232-6241.1998 · doi:10.1128/jb.180.23.6232-6241.1998 · Paper page
  4. Cheung, A. L., A. S. Bayer, G. Zhang, H. Gresham, and Y.-Q. Xiong. 2004. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Microbiol. Lett. 1649 : 1-9.
  5. 10.1128/IAI.67.3.1331-1337.1999 · DOI
  6. 10.1128/IAI.73.7.4391-4394.2005 · doi:10.1128/iai.73.7.4391-4394.2005
  7. 10.1128/IAI.66.12.5988-5993.1998 · DOI
  8. Chien, C.-T., A. C. Manna, S. J. Projan, and A. L. Cheung. 1999. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J. Biol. Chem. 274 : 37169-37176. · DOI · Paper page
  9. 10.1128/JB.183.24.7341-7353.2001 · DOI · Paper page
  10. 10.1128/JB.183.6.1843-1852.2001 · DOI · Paper page
  11. Hong, M., M. Fuangthong, J. D. Helmann, and R. G. Brennan. 2005. Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. Mol. Cell 20 : 131-141. · DOI · Paper page
  12. Liu, Y., A. C. Manna, R. Li, W. E. Martin, A. L. Cheung, and G. Zhang. 2001. Crystal structure of the SarR protein from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 98 : 6877-6882. · DOI
  13. Liu, Y., A. C. Manna, C. H. Pan, I. A. Kriksunov, D. J. Thiel, A. L. Cheung, and G. Zhang. 2006. Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 103 : 2392-2397. · DOI
  14. 10.1056/NEJM199808203390806 · DOI · Paper page
  15. 10.1128/JB.180.15.3828-3836.1998 · DOI
  16. 10.1128/IAI.69.2.885-896.2001 · DOI
  17. 10.1128/JB.181.9.2846-2851.1999 · DOI
  18. Munson, G. P., and J. R. Scott. 2000. Rns, a virulence regulator within the AraC family, requires binding sites upstream and downstream of its own promoter to function as an activator. Mol. Microbiol. 36 : 1391-1402. · doi:10.1046/j.1365-2958.2000.01957.x
  19. Novick, R. P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48 : 1429-1449. · DOI · Paper page
  20. 10.1128/IAI.69.12.7858-7865.2001 · DOI
  21. Safo, M. K., T. P. Ko, F. N. Musayev, Q. Zhao, A. H. Wang, and G. L. Archer. 2006. Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62 : 320-324. · DOI
  22. 10.1128/JB.187.5.1833-1844.2005 · DOI
  23. Wolz, C., A. Steinhuber, P. Pohlmann-Dietze, Y. T. Chien, A. C. Manna, W. Van Wamel, and A. L. Cheung. 2000. Agr-independent regulation of fibronectin binding protein(s) by the regulatory locus sar in Staphylococcus aureus. Mol. Microbiol. 36 : 230-243. · DOI

Cited by

See all 56

Metadata

Authors
Cheung, A. L., Nishina, K., & Manna, A. C.
Affiliations
  • Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755
  • Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota 57069
Venue
Journal of Bacteriology
Published
2008-03-15
Volume
190
Issue
6
Pages
2239-2243
ISSN
  • 0021-9193
  • 1098-5530
Cited by
56
References
0
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression. https://app.cochat.ai/papers/10.1128/jb.01826-07
The paper
Cheung, A. L., Nishina, K., & Manna, A. C. (2008). SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression. Journal of Bacteriology. https://doi.org/10.1128/jb.01826-07

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.