The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transcription Profiling-Based Identification of Staphylococcus aureus Genes Regulated by the agr and/or sarA Loci
Abstract
The advent of transcription profiling technologies has provided researchers with an unprecedented ability to study biological processes. Accordingly, a custom-made Affymetrix GeneChip, constituting >86% of the Staphylococcus aureus genome, was used to identify open reading frames that are regulated by agr and/or SarA, the two best-studied regulators of the organism's virulence response. RNA extracted from wild-type cells and agr , sarA , and agr sarA mutant cells in the early-, mid-, and late-log and stationary phases of growth was analyzed. Open reading frames with transcription patterns expected of genes either up- or downregulated in an agr - and/or SarA-dependent manner were identified. Oligonucleotide microarray and Northern blot analyses confirmed that the transcription of several known virulence genes, including hla (alpha-toxin) and spa (protein A), is regulated by each effector and provided insights about the regulatory cascades involved in both alpha-hemolysin and protein A expression. Several putative virulence factors were also identified as regulated by agr and/or SarA. In addition, genes that are involved in several biological processes but which are difficult to reconcile as playing a direct role in the organism's pathogenesis also appeared to be regulated by each effector, suggesting that products of both the agr and the sarA locus are more-global transcription regulators than previously realized.
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Citations
Cites
Regulation of protein A synthesis by the sar and agr loci of Staphylococcus aureus
Cheung, A. L., Eberhardt, K., & Heinrichs, J. H. (1997) · Infection and Immunity · doi:10.1128/iai.65.6.2243-2249.1997 · Cited by 122
Cited by
Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
Boisset, S., Geissmann, T., Huntzinger, E., Fechter, P., Bendridi, N., Possedko, M., Chevalier, C., Helfer, A. C., Benito, Y., Jacquier, A., et al. (2007) · Genes & Development · doi:10.1101/gad.423507 · Cited by 490
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Methicillin-Resistant Staphylococcus aureus: An Evolving Pathogen
Stryjewski, M. E., & Corey, G. R. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/cit613 · Cited by 334
Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species
Ramsey, M. M., Freire, M. O., Gabrilska, R. A., Rumbaugh, K. P., & Lemon, K. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01230 · Cited by 299
Metadata
- Authors
- Dunman, P. M., Murphy, E., Haney, S., Palacios, D., Tucker-Kellogg, G., Wu, S., Brown, E. L., Zagursky, R. J., Shlaes, D., & Projan, S. J.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2001-12-15
- Volume
- 183
- Issue
- 24
- Pages
- 7341-7353
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2167665502
- Cited by
- 648
- References
- 1
- FWCI
- 19.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dunman, P. M., Murphy, E., Haney, S., Palacios, D., Tucker-Kellogg, G., Wu, S., Brown, E. L., Zagursky, R. J., Shlaes, D., & Projan, S. J. (2001). Transcription Profiling-Based Identification of Staphylococcus aureus Genes Regulated by the agr and/or sarA Loci. Journal of Bacteriology. https://doi.org/10.1128/jb.183.24.7341-7353.2001
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