Cited by 178Anaerobic Digestion and Biogas ProductionMicrobial metabolism and enzyme functionGut microbiota and health

Genome Sequence of “Candidatus Methanomethylophilus alvus” Mx1201, a Methanogenic Archaeon from the Human Gut Belonging to a Seventh Order of Methanogens

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Borrel, Guillaume, Harris, Hugh M. B., Tottey, William, Mihajlovski, Agnès, Parisot, Nicolas, Peyretaillade, Eric, Peyret, Pierre, Gribaldo, Simonetta +2 more·2012·Journal of Bacteriology

Abstract

We report the draft genome sequence of “ Candidatus Methanomethylophilus alvus” Mx1201, a methanogen present in the human gut. It was enriched from human feces under anaerobic conditions with methanol as the substrate. Its circular genome, of around 1.7 Mb, contains genes needed for methylotrophic methanogenesis from methanol and tri-, di-, and monomethylamine.

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Crossref · 10.1128/jb.01867-12

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  • TMA can be used for methanogenesis in the gastrointestinal tract, and this pathway is active in human intestine bacteria including Methanomassiliicoccus, Methanomethylophilus, Methanobrevibacter smithii, and Methanosphaera stadtmanae.

    “TMA can be used for methanogenesis in the gastrointestinal tract; in human intestine, this pathway is active in bacteria belonging to the genera Methanomassiliicoccus and Methanomethylophilus (18,21,38) as well as in Methanobrevibacter smithii and Methanosphaera stadtmanae (41).”
  • TMA can be used for methanogenesis in the gastrointestinal tract, and bacteria of the genera Methanomassiliicoccus and Methanomethylophilus have this pathway.

    “TMA can be used for methanogenesis in the gastrointestinal tract, and bacteria belonging to the genera Methanomassiliicoccus and Methanomethylophilus have this pathway (18,21,38,41).”

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Authors
Borrel, G., Harris, H. M. B., Tottey, W., Mihajlovski, A., Parisot, N., Peyretaillade, E., Peyret, P., Gribaldo, S., O'Toole, P. W., & Brugère, J.-F.
Affiliations
  • Université Clermont Auvergne (FR)
  • University College Cork (IE)
  • EA-4678 CIDAM, Conception Ingénierie et Développement de l'Aliment et du Médicament, Clermont Université, Université d'Auvergne, Clermont-Ferrand, France
  • Institut Pasteur (FR)
  • Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Venue
Journal of Bacteriology
Published
2012-12-15
Volume
194
Issue
24
Pages
6944-6945
ISSN
  • 0021-9193 (ISSN-L)
  • 1098-5530
OpenAlex
W2087706124
Cited by
166
References
17
Citations by year
2026: 3 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 12 · 2018: 23 · 2017: 14 · 2016: 10 · 2015: 21 · 2014: 14 · 2013: 6
FWCI
25.37
Type
journal article
Language
en
Open access
Locations
  • Journal of Bacteriology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Topics
  • Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
methanogenic archaea, human gut microbiome, methylotrophic methanogenesis, methanol metabolism, methylamine, draft genome sequence, archaeal phylogeny
MeSH terms
Aged, Aged, 80 and over, Methanol, Anaerobiosis, Archaea, Feces, Humans, Methyltransferases, Molecular Sequence Data, RNA, Ribosomal, 16S, RNA, Ribosomal, 23S, Sequence Analysis, DNA, DNA, Archaeal, Genome, Archaeal, Gastrointestinal Tract

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