The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes
Open accessAbstract
Pseudomonas aeruginosa is usually resistant to a wide variety of antibacterial agents, and it has been inferred, on the basis of indirect evidence, that this was due to the low permeability of its outer membrane. We determined the permeability of P. aeruginosa outer membrane directly, by measuring the rates of hydrolysis of cephacetrile, cephaloridine, and various phosphate esters by hydrolytic enzymes located in the periplasm. The permeability to these compounds was about 100-fold lower than in the outer membrane of Escherichia coli K-12. Also, we found that the apparent Km values for active transport of various carbon and energy source compounds were typically higher than 20 microM in P. aeruginosa, in contrast to E. coli in which the values are usually lower than 5 microM. These results also are consistent with the notion that the P. aeruginosa outer membrane indeed has a low permeability to most hydrophilic compounds and that this membrane acts as a rate limiting step in active transport processes with high Vmax values.
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Cites
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The β-Lactamases of Gram-Negative Bacteria and their Possible Physiological Role
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The Outer Membrane of Gram-negative Bacteria
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Self-citationSmit, J., Kamio, Y., & Nikaido, H. (1975) · Journal of Bacteriology · doi:10.1128/jb.124.2.942-958.1975 · Cited by 360
Self-citationAngus, B. L., Carey, A. M., Caron, D. A., Kropinski, A. M., & Hancock, R. E. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.2.299 · Cited by 262
Cited by
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Self-citationA Deep Learning Approach to Antibiotic Discovery
Stokes, J. M., Yang, K., Swanson, K., Jin, W., Cubillos-Ruiz, A., Donghia, N. M., MacNair, C. R., French, S., Carfrae, L. A., Bloom-Ackermann, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.021 · Cited by 2,463
Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux
Nikaido, H. (1994) · Science · doi:10.1126/science.8153625 · Cited by 1,540
Self-citationMultidrug efflux pumps of gram-negative bacteria
Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.20.5853-5859.1996 · Cited by 1,082
Self-citationLugtenberg, B., & Van Alphen, L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90014-x · Cited by 759
Metadata
- Authors
- Yoshimura, F., & Nikaido, H.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1982-11
- Volume
- 152
- Issue
- 2
- Pages
- 636-642
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1915829691
- Cited by
- 274
- References
- 27
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
