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Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction
Open accessAbstract
Glycerol monolaurate (GML) is a naturally occurring surfactant that is used widely as an emulsifier in the food and cosmetics industries and is generally regarded as lacking in important biological activities. The recent observation that it inhibits the production of staphylococcal toxic shock toxin-1 (P. M. Schlievert, J. R. Deringer, M. H. Kim, S. J. Projan, and R. P. Novick, Antimicrob. Agents Chemother. 36:626-631, 1992) is therefore rather surprising and raises the interesting question of how such a compound might interact with cells. In this report, we show that GML inhibits the synthesis of most staphylococcal toxins and other exoproteins and that it does so at the level of transcription. We find that GML blocks the induction but not the constitutive synthesis of beta-lactamase, suggesting that it acts by interfering with signal transduction.
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“GML also inhibits the production of staphylococcal toxic shock toxin-1 effectively and the expression of virulence factors including protein A, alpha-hemolysin, β-lactamase, and the induction of vancomycin resistance in Enterococcus faecalis by interfering with signal transduction (Projan et al., 1994; Ruzin and Novick, 2000).”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Projan et al., 1994
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Self-citationThe Properties of Lauric Acid and Their Significance in Coconut Oil
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Metadata
- Authors
- Projan, S. J., Brown-Skrobot, S., Schlievert, P. M., Vandenesch, F., & Novick, R. P.
- Affiliations
- Applied Microbiology, Inc., New York, New York.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1994-07
- Volume
- 176
- Issue
- 14
- Pages
- 4204-4209
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC205630
- OpenAlex
- W2138691817
- Cited by
- 151
- References
- 27
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 14 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 8 · 2013: 4 · 2012: 8
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 30138)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- glycerol monolaurate, Staphylococcus aureus, beta-lactamase, signal transduction, transcriptional regulation, surfactants
- MeSH terms
- Bacterial Proteins, Bacterial Toxins, beta-Lactamases, Enterotoxins, Enzyme Induction, Exotoxins, Glycerides, Hemolysin Proteins, Laurates, Operon, Staphylococcal Protein A, Staphylococcus aureus, Transcription, Genetic, Signal Transduction, Superantigens, Monoglycerides
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