Equivalence of Lauric Acid and Glycerol Monolaurate as Inhibitors of Signal Transduction in Staphylococcus aureus
Open accessAbstract
Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis , presumably by blocking signal transduction. Although GML is rapidly hydrolyzed by bacteria, one of the products, lauric acid, has identical inhibitory activity and is metabolized much more slowly. At least four distinct GML-hydrolyzing activities are identified in S. aureus : the secreted Geh lipase, residual supernatant activity in a geh -null mutant strain, a novel membrane-bound esterase, and a cytoplasmic activity.
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Glycerol monolaurate inhibits the production of staphylococcal toxic shock toxin-1 and the expression of virulence factors including protein A, alpha-hemolysin, β-lactamase, and the induction of vancomycin resistance in Enterococcus faecalis by interfering with signal transduction.
“GML also inhibits the production of staphylococcal toxic shock toxin-1 effectively and the expression of virulence factors including protein A, alpha-hemolysin, β-lactamase, and the induction of vancomycin resistance in Enterococcus faecalis by interfering with signal transduction (Projan et al., 1994; Ruzin and Novick, 2000).”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Ruzin and Novick, 2000
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Projan, S. J., Brown-Skrobot, S., Schlievert, P. M., Vandenesch, F., & Novick, R. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.14.4204-4209.1994 · Cited by 151 · see citing works
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The Properties of Lauric Acid and Their Significance in Coconut Oil
Dayrit, F. M. (2015) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-014-2562-7 · Cited by 479 · see citing works
The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin
Clarke, S. R., Mohamed, R., Bian, L., Routh, A. F., Kokai-Kun, J. F., Mond, J. J., Tarkowski, A., & Foster, S. J. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.04.005 · Cited by 225 · see citing works
Glycerol monolaurate antibacterial activity in broth and biofilm cultures.
Schlievert, P. M., & Peterson, M. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040350 · Cited by 198 · see citing works
Preuss, H. G., Echard, B., Enig, M., Brook, I., & Elliott, T. B. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-6604-1 · Cited by 180 · see citing works
Borrelli, L., Varriale, L., Dipineto, L., Pace, A., Menna, L. F., & Fioretti, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.620798 · Cited by 159 · see citing works
A Review of Monolaurin and Lauric Acid: <i>Natural Virucidal and Bactericidal Agents</i>
Lieberman, S., Enig, M. G., & Preuss, H. G. (2006) · Alternative and Complementary Therapies · doi:10.1089/act.2006.12.310 · Cited by 153 · see citing works
- Authors
- Ruzin, A., & Novick, R. P.
- Affiliations
- NYU Langone Health (US)
- ORCID
- Novick, Richard P.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2000-05
- Volume
- 182
- Issue
- 9
- Pages
- 2668-2671
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC111339
- OpenAlex
- W2116292474
- Cited by
- 105
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 9
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI RO1-30138, AI RO1-22159)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- glycerol monolaurate, lauric acid, Staphylococcus aureus, signal transduction inhibition, virulence factor expression, vancomycin resistance, Enterococcus faecalis, antimicrobial peptides
- MeSH terms
- Chromatography, Thin Layer, Glycerides, Hydrolases, Laurates, Lauric Acids, Staphylococcus aureus, Signal Transduction, Monoglycerides
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