The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Inorganic polyphosphate supports resistance and survival of stationary-phase Escherichia coli
Open accessAbstract
The Escherichia coli mutant (ppk) lacking the enzyme polyphosphate kinase, which makes long chains of inorganic polyphosphate (poly P), is deficient in functions expressed in the stationary phase of growth. After 2 days of growth in a medium limited in carbon sources, only 7% of the mutants survived compared with nearly 100% of the wild type; the loss in viability of the mutant was even more pronounced in a rich medium. The mutant showed a greater sensitivity to heat, to an oxidant (H2O2), to a redox-cycling agent (menadione), and to an osmotic challenge with 2.5 M NaCl. After a week or so in the stationary phase, mutant survivors were far fewer in number and were replaced by an outgrowth of a small-colony-size variant with a stable genotype and with improved viability and resistance to heat and H2O2; neither polyphosphate kinase nor long-chain poly P was restored. Suppression of the ppk feature of heat sensitivity by extra copies of rpoS, the gene encoding the RNA polymerase sigma factor that regulates some 50 stationary-phase genes, further implicates poly P in promoting survival in the stationary phase.
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Cites
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Hengge-Aronis, R. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.373-395.2002 · Cited by 936
Acidocalcisomes ? conserved from bacteria to man
Docampo, R., de Souza, W., Miranda, K., Rohloff, P., & Moreno, S. N. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1097 · Cited by 468
Inorganic polyphosphate in the origin and survival of species
Brown, M. R. W., & Kornberg, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406909101 · Cited by 327
Self-citationPolyphosphate Kinase Protects Salmonella enterica from Weak Organic Acid Stress
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Bittner, L.-M., Westphal, K., & Narberhaus, F. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.648550 · Cited by 34
Metadata
- Authors
- Rao, N. N., & Kornberg, A.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1996-03
- Volume
- 178
- Issue
- 5
- Pages
- 1394-1400
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1639192928
- Cited by
- 269
- References
- 50
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Rao, N. N., & Kornberg, A. (1996). Inorganic polyphosphate supports resistance and survival of stationary-phase Escherichia coli. Journal of Bacteriology. https://doi.org/10.1128/jb.178.5.1394-1400.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
