Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum
Open accessAbstract
Ten strains of Lactobacillus fermentum that differed in origin converted metmyoglobin to nitrosylmyoglobin [a pentacoordinate nitric oxide (NO) complex of Fe(II) myoglobin] in MRS broth at pH 4.3. Of the 10 strains, L. fermentum IFO 3956 possessed the strongest capacity to convert metmyoglobin to nitrosylmyoglobin. This strain synthesizes NO enzymatically from the two equivalent guanidino nitrogens of L-arginine. To our knowledge, this demonstrates for the first time the production of NO synthesized from the guanidino nitrogens of L-arginine by lactic acid bacteria. IFO 3956 may possess a bacterial NO synthase.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Bergey's Manual of Systematic Bacteriology
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-391_3 · Cited by 15,633 · see citing works
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350 · see citing works
Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979 · see citing works
Biosynthesis and metabolism of arginine in bacteria
Cunin, R., Glansdorff, N., Pierard, A., & Stalon, V. (1986) · Microbiological Reviews · doi:10.1128/mr.50.3.314-352.1986 · Cited by 831 · see citing works
Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816 · see citing works
Iyengar, R., Stuehr, D. J., & Marletta, M. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6369 · Cited by 664 · see citing works
Mammalian Nitric Oxide Synthases
Stuehr, D. J., & Griffith, O. W. (1992) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123119.ch8 · Cited by 507 · see citing works
Hevel, J. M., White, K. A., & Marletta, M. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54421-5 · Cited by 455 · see citing works
Denitrification: production and consumption of nitric oxide
Ye, R. W., Averill, B. A., & Tiedje, J. M. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.4.1053-1058.1994 · Cited by 288 · see citing works
Papen, H., von Berg, R., Hinkel, I., et al. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.8.2068-2072.1989 · Cited by 193 · see citing works
Regulation of arginine-ornithine exchange and the arginine deiminase pathway in Streptococcus lactis
Poolman, B., Driessen, A. J. M., & Konings, W. N. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.12.5597-5604.1987 · Cited by 165 · see citing works
Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species
Chen, Y., & Rosazza, J. P. N. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.17.5122-5128.1995 · Cited by 115 · see citing works
A Bacterial, Nitric Oxide Synthase from a Nocardia Species
Chen, Y., & Rosazza, J. P. N. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2317 · Cited by 103 · see citing works
Tesch, J., Rehg, W. R., & Sievers, R. E. (1976) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)84117-0 · Cited by 78 · see citing works
Myoglobin-NO at Low pH: Free Four-Coordinated Heme in the Protein Pocket
Duprat, A. F., Traylor, T. G., Wu, G., et al. (1995) · Biochemistry · doi:10.1021/bi00008a030 · Cited by 68 · see citing works
Arihara, K., KUSHIDA, H., KONDO, Y., ITOH, M., Luchansky, J. B., & CASSENS, R. G. (1993) · Journal of Food Science · doi:10.1111/j.1365-2621.1993.tb03205.x · Cited by 68 · see citing works
The kinetic and isotopic competence of nitric oxide as an intermediate in denitrification.
Goretski, J., & Hollocher, T. C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40133-6 · Cited by 66 · see citing works
Secretory functions of the vascular endothelium.
Vane, J. R., & Botting, R. M. (1992) · PubMed · Cited by 33 · see citing works
Pegg, R. B., Shahidi, F., Gogan, N. J., et al. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950319g · Cited by 21 · see citing works
Morita, H., Sakata, R., Sonoki, S., et al. (1994) · Nihon Chikusan Gakkaiho · doi:10.2508/chikusan.65.1026 · Cited by 12 · see citing works
Self-citationA Method for the Determination of Total Heme Pigments in Meat Products
OKAYAMA, T., & NAGATA, Y. (1979) · Nihon Chikusan Gakkaiho · doi:10.2508/chikusan.50.15 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Espey, M. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.554 · Cited by 396 · see citing works
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Bacterial nitric oxide synthases: what are they good for?
Sudhamsu, J., & Crane, B. R. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2009.02.003 · Cited by 160 · see citing works
Evaluation of nitric oxide production by lactobacilli
Xu, J., & Verstraete, W. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100616 · Cited by 67 · see citing works
- Authors
- Morita, H., Yoshikawa, H., Sakata, R., Nagata, Y., & Tanaka, H.
- Affiliations
- Azabu University (JP)
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1997-12
- Volume
- 179
- Issue
- 24
- Pages
- 7812-7815
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC179746
- OpenAlex
- W1628547227
- Cited by
- 99
- References
- 23
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 5 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- nitric oxide production, L-arginine, Lactobacillus fermentum, nitrosylmyoglobin, metmyoglobin, lactic acid bacteria
- MeSH terms
- Arginine, Guanidines, Lactobacillus, Metmyoglobin, Myoglobin, Nitric Oxide, Species Specificity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
