Cited by 200Fungal and yeast genetics researchAntifungal resistance and susceptibilityPolysaccharides and Plant Cell Walls

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Loss of the Plasma Membrane-Bound Protein Gas1p in Saccharomyces cerevisiae Results in the Release of β1,3-Glucan into the Medium and Induces a Compensation Mechanism To Ensure Cell Wall Integrity

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Ram, Arthur F. J., Kapteyn, Johan C., Montijn, Roy C., Caro, L. Heleen P., Douwes, Jeroen E., Baginsky, Walter, Mazur, Paul, van den Ende, Herman, Klis, Frans M.·1998·Journal of Bacteriology

DOI 10.1128/jb.180.6.1418-1424.1998PMC PMC107039

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Abstract

Deletion of GAS1/GGP1/CWH52 results in a lower β-glucan content of the cell wall and swollen, more spherical cells (L. Popolo, M. Vai, E. Gatti, S. Porello, P. Bonfante, R. Balestrini, and L. Alberghina, J. Bacteriol. 175:1879–1885, 1993; A. F. J. Ram, S. S. C. Brekelmans, L. J. W. M. Oehlen, and F. M. Klis, FEBS Lett. 358:165–170, 1995). We show here that gas1 Δ cells release β1,3-glucan into the medium. Western analysis of the medium proteins with β1,3-glucan- and β1,6-glucan-specific antibodies showed further that at least some of the released β1,3-glucan was linked to protein as part of a β1,3-glucan–β1,6-glucan–protein complex. These data indicate that Gas1p might play a role in the retention of β1,3-glucan and/or β-glucosylated proteins. Interestingly, the defective incorporation of β1,3-glucan in the cell wall was accompanied by an increase in chitin and mannan content in the cell wall, an enhanced expression of cell wall protein 1 (Cwp1p), and an increase in β1,3-glucan synthase activity, probably caused by the induced expression of Fks2p. It is proposed that the cell wall weakening caused by the loss of Gas1p induces a set of compensatory reactions to ensure cell integrity.

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Authors: Ram, A. F. J., Kapteyn, J. C., Montijn, R. C., Caro, L. H. P., Douwes, J. E., Baginsky, W., Mazur, P., van den Ende, H., & Klis, F. M.
Affiliations: University of Amsterdam (NL)
Institute of Molecular Cell Biology, BioCentrum Amsterdam, University of Amsterdam, 1098 SM Amsterdam,1 and
Wageningen University & Research (NL)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
ORCID: Ram, Arthur F. J.
Douwes, Jeroen E.
Venue: Journal of Bacteriology
Publisher: American Society for Microbiology
Published: 1998-03-15
Volume: 180
Issue: 6
Pages: 1418-1424
ISSN: 0021-9193 (ISSN-L)
1098-5530
DOI: 10.1128/jb.180.6.1418-1424.1998
PMC: PMC107039
OpenAlex: W2152455126
Cited by: 200
References: 62
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 7
FWCI: 4.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Bacteriology (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: plasma membrane proteins, cell wall integrity, chitin, mannan, Saccharomyces cerevisiae
MeSH terms: Carbohydrates, Cell Wall, Chitin, Cloning, Molecular, DNA, Fungal, Fungal Proteins, Glucans, Glucosyltransferases, Glycoproteins, Mannans, Membrane Glycoproteins, Membrane Proteins, Plasmids, Recombination, Genetic, RNA, Fungal, Saccharomyces cerevisiae, Blotting, Western, Gene Expression, Polymerase Chain Reaction, Culture Media, Conditioned, Sequence Deletion, Saccharomyces cerevisiae Proteins, beta-Glucans, Carbohydrate Metabolism

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Loss of the Plasma Membrane-Bound Protein Gas1p in Saccharomyces cerevisiae Results in the Release of β1,3-Glucan into the Medium and Induces a Compensation Mechanism To Ensure Cell Wall Integrity

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